CA2239366A1 - Recombinase-mediated generation of adenoviral vectors - Google Patents
Recombinase-mediated generation of adenoviral vectors Download PDFInfo
- Publication number
- CA2239366A1 CA2239366A1 CA002239366A CA2239366A CA2239366A1 CA 2239366 A1 CA2239366 A1 CA 2239366A1 CA 002239366 A CA002239366 A CA 002239366A CA 2239366 A CA2239366 A CA 2239366A CA 2239366 A1 CA2239366 A1 CA 2239366A1
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- Prior art keywords
- adenoviral
- polynucleotide
- itr
- retroviral
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
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- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Oscillators With Electromechanical Resonators (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
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| US58370396A | 1996-01-05 | 1996-01-05 | |
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| CA2239366A1 true CA2239366A1 (en) | 1997-07-17 |
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| US6730507B1 (en) | 1993-06-24 | 2004-05-04 | Merck & Co., Inc. | Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration |
| US6756226B2 (en) * | 1994-05-31 | 2004-06-29 | Frank L. Graham | Enhanced system for construction of adenovirus vectors |
| US6379943B1 (en) * | 1999-03-05 | 2002-04-30 | Merck & Co., Inc. | High-efficiency Cre/loxp based system for construction of adenovirus vectors |
| US6974694B2 (en) | 1995-06-07 | 2005-12-13 | Advec, Inc. | Adenoviruses for control of gene expression |
| US6720140B1 (en) | 1995-06-07 | 2004-04-13 | Invitrogen Corporation | Recombinational cloning using engineered recombination sites |
| US6964861B1 (en) | 1998-11-13 | 2005-11-15 | Invitrogen Corporation | Enhanced in vitro recombinational cloning of using ribosomal proteins |
| US6143557A (en) * | 1995-06-07 | 2000-11-07 | Life Technologies, Inc. | Recombination cloning using engineered recombination sites |
| EP0937098B1 (en) | 1995-06-07 | 2002-08-14 | Invitrogen Corporation | Recombinational cloning in vitro using engineered recombination sites |
| FR2749857B1 (fr) * | 1996-06-12 | 1998-08-14 | Centre Nat Rech Scient | Generation de molecules replicatives in vivo |
| EP0956052B1 (en) * | 1996-11-19 | 2005-04-13 | University Of Alabama, Birmingham Research Foundation | Chimeric retrovirus/adenovirus system |
| US6403370B1 (en) * | 1997-02-10 | 2002-06-11 | Genstar Therapeutics Corporation | Oncolytic/immunogenic complementary-adenoviral vector system |
| US7030096B1 (en) * | 1997-02-13 | 2006-04-18 | Albert Einstein College Of Medicine Of Yeshiva University | Method of enhancing relaxation of penile smooth muscle by introduction of DNA encoding maxi-K potassium channel protein |
| US5851808A (en) | 1997-02-28 | 1998-12-22 | Baylor College Of Medicine | Rapid subcloning using site-specific recombination |
| IL131979A0 (en) | 1997-03-21 | 2001-03-19 | Enzo Therapeutics Inc | Vectors and viral vectors and packaging cell lines for propagating the same |
| WO1998046778A1 (en) * | 1997-04-11 | 1998-10-22 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Transgenomic viruses and the use thereof |
| WO1999015686A1 (en) | 1997-09-23 | 1999-04-01 | Genvec, Inc. | Plasmids for construction of eukaryotic viral vectors |
| US7351578B2 (en) | 1999-12-10 | 2008-04-01 | Invitrogen Corp. | Use of multiple recombination sites with unique specificity in recombinational cloning |
| DE69836092T2 (de) * | 1997-10-24 | 2007-05-10 | Invitrogen Corp., Carlsbad | Rekombinatorisches klonieren unter verwendung von nukleinsaüren mit rekombinationsstellen |
| DE19807265C2 (de) * | 1998-02-20 | 2000-01-05 | Centeon Pharma Gmbh | Adenoviraler Transfervektor für den Gentransport einer DNA-Sequenz |
| US6413776B1 (en) * | 1998-06-12 | 2002-07-02 | Galapagos Geonomics N.V. | High throughput screening of gene function using adenoviral libraries for functional genomics applications |
| US6576463B1 (en) | 1999-01-15 | 2003-06-10 | The Regents Of The University Of California | Hybrid vectors for gene therapy |
| DE60042969D1 (de) | 1999-03-02 | 2009-10-29 | Life Technologies Corp | Zubereitungen und methoden zur verwendung in rekombinatorischem klonen von nukleinsäuren |
| EP1159439B1 (en) * | 1999-03-05 | 2014-01-08 | Advec Inc. | Enhanced system for construction of adenovirus vectors |
| ATE391789T1 (de) | 1999-12-10 | 2008-04-15 | Invitrogen Corp | Verwendung einer vielzahl von rekombinationsstellen mit einzigartiger spezifität beim rekombinatorischen klonen |
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| EP1379281A4 (en) * | 2001-03-26 | 2005-05-18 | Univ Leland Stanford Junior | HELPER-DEPENDENT ADENOVIRUS VECTOR SYSTEM AND METHOD FOR ITS USE |
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| US20040203133A1 (en) * | 2003-01-07 | 2004-10-14 | Anja Ehrhardt | Helper dependent adenoviral vector system and methods for using the same |
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| CA2574802A1 (en) | 2004-07-20 | 2006-02-02 | Isogenis, Inc. | Specific inhibition of autoimmunity and diseases associated with autoantigens |
| CN101094688B (zh) | 2004-09-13 | 2013-05-01 | 建新公司 | 多聚构建体 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1293460C (en) * | 1985-10-07 | 1991-12-24 | Brian Lee Sauer | Site-specific recombination of dna in yeast |
| WO1994023582A1 (en) * | 1993-04-08 | 1994-10-27 | Genetic Therapy, Inc. | Adenoviral vectors including dna encoding lung surfactant protein |
| US5919676A (en) * | 1993-06-24 | 1999-07-06 | Advec, Inc. | Adenoviral vector system comprising Cre-loxP recombination |
| US6686200B1 (en) * | 1993-08-31 | 2004-02-03 | Uab Research Foundation | Methods and compositions for the large scale production of recombinant adeno-associated virus |
| EP0784690B1 (en) * | 1994-06-10 | 2006-08-16 | Genvec, Inc. | Complementary adenoviral vector systems and cell lines |
| US5650309A (en) * | 1995-05-16 | 1997-07-22 | The Regents Of The University Of California | Viral vectors |
-
1997
- 1997-01-03 WO PCT/US1997/000370 patent/WO1997025446A1/en not_active Ceased
- 1997-01-03 JP JP9525405A patent/JP2000503534A/ja not_active Ceased
- 1997-01-03 CA CA002239366A patent/CA2239366A1/en not_active Abandoned
- 1997-01-03 US US09/051,579 patent/US6156497A/en not_active Expired - Fee Related
- 1997-01-03 EP EP97902882A patent/EP0927263A1/en not_active Withdrawn
- 1997-01-03 AU AU16951/97A patent/AU1695197A/en not_active Abandoned
- 1997-01-03 NZ NZ330553A patent/NZ330553A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000503534A (ja) | 2000-03-28 |
| EP0927263A1 (en) | 1999-07-07 |
| EP0927263A4 (enExample) | 1999-07-07 |
| WO1997025446A1 (en) | 1997-07-17 |
| US6156497A (en) | 2000-12-05 |
| NZ330553A (en) | 2001-04-27 |
| AU1695197A (en) | 1997-08-01 |
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