CA2238860C - Stereoisomers of fatty acid analogs for diagnostic imaging - Google Patents

Stereoisomers of fatty acid analogs for diagnostic imaging Download PDF

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Publication number
CA2238860C
CA2238860C CA002238860A CA2238860A CA2238860C CA 2238860 C CA2238860 C CA 2238860C CA 002238860 A CA002238860 A CA 002238860A CA 2238860 A CA2238860 A CA 2238860A CA 2238860 C CA2238860 C CA 2238860C
Authority
CA
Canada
Prior art keywords
group
hydrogen
agent
stereoisomer
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002238860A
Other languages
English (en)
French (fr)
Other versions
CA2238860A1 (en
Inventor
David R. Elmaleh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecular Insight Pharmaceuticals Inc
Original Assignee
Molecular Insight Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Insight Pharmaceuticals Inc filed Critical Molecular Insight Pharmaceuticals Inc
Publication of CA2238860A1 publication Critical patent/CA2238860A1/en
Application granted granted Critical
Publication of CA2238860C publication Critical patent/CA2238860C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Nuclear Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA002238860A 1995-12-01 1996-11-25 Stereoisomers of fatty acid analogs for diagnostic imaging Expired - Fee Related CA2238860C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US786395P 1995-12-01 1995-12-01
US60/007,863 1995-12-01
PCT/US1996/019024 WO1997019705A1 (en) 1995-12-01 1996-11-25 Stereoisomers of fatty acid analogs for diagnostic imaging

Publications (2)

Publication Number Publication Date
CA2238860A1 CA2238860A1 (en) 1997-06-05
CA2238860C true CA2238860C (en) 2009-01-13

Family

ID=21728502

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002238860A Expired - Fee Related CA2238860C (en) 1995-12-01 1996-11-25 Stereoisomers of fatty acid analogs for diagnostic imaging

Country Status (9)

Country Link
US (4) US7005119B2 (US20080242721A1-20081002-C00053.png)
EP (2) EP0869821B1 (US20080242721A1-20081002-C00053.png)
JP (3) JP4272259B2 (US20080242721A1-20081002-C00053.png)
AT (2) ATE353019T1 (US20080242721A1-20081002-C00053.png)
CA (1) CA2238860C (US20080242721A1-20081002-C00053.png)
DE (1) DE69636881T2 (US20080242721A1-20081002-C00053.png)
ES (2) ES2281906T3 (US20080242721A1-20081002-C00053.png)
HK (2) HK1016494A1 (US20080242721A1-20081002-C00053.png)
WO (1) WO1997019705A1 (US20080242721A1-20081002-C00053.png)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69636881T2 (de) * 1995-12-01 2007-09-20 Molecular Insight Pharmaceuticals, Inc., Cambridge Stereoisomere von fettsäureanalogen zur diagnostischen bildgebung
US20090117032A1 (en) * 1998-09-08 2009-05-07 The General Hospital Corporation Imaging Agents for Early Detection and Monitoring of Cardiovascular Plaque
EP0992245A1 (en) * 1998-09-16 2000-04-12 Goldham Bioglan Pharma GmbH Radio-contrast agents
EP1040825A1 (en) * 1999-03-11 2000-10-04 K.U. Leuven Research & Development Means for diagnosing bladder carcinoma
US6437103B1 (en) 1999-04-14 2002-08-20 Biostream Inc. Fatty acid analogs for diagnosis of coronary artery disease
JP4951798B2 (ja) 2002-04-01 2012-06-13 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド 側基脂肪酸撮像剤
AU2004232297B2 (en) * 2003-04-17 2010-11-04 The General Hospital Corporation Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid
US20120100073A1 (en) * 2009-05-04 2012-04-26 Washington University Pet radiotracers for imaging fatty acid metabolism and storage
DE102010010666A1 (de) * 2010-03-01 2011-09-01 Sven Reske Diagnose und Therapie von Krebserkrankungen mittels Fettsäuren

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6802651A (US20080242721A1-20081002-C00053.png) * 1968-02-23 1969-08-26
DE2828623C2 (de) * 1978-06-29 1983-11-17 Kernforschungsanlage Jülich GmbH, 5170 Jülich Mit radioaktivem Flour markierte C↓1↓↓6↓-bis C↓1↓↓8↓- Fettsäuren, ein Verfahren zu ihrer Herstellung sowie deren Verwendung
DE2947500C2 (de) * 1979-11-24 1984-05-10 Dutschka, Klaus, 4300 Essen Radiojodierte ω -Phenylfettsäuren, ihre Herstellung und deren Verwendung zur szintigraphischen Untersuchung des Herzmuskels und der Leber
FR2508902B1 (fr) * 1981-07-02 1985-09-06 Commissariat Energie Atomique Procede de preparation extemporanee d'un acide gras injectable, marque a l'iode radioactif et preparation de derives iodes utilisables pour la mise en oeuvre de ce procede
US4524059A (en) * 1983-01-28 1985-06-18 The General Hospital Corporation Fatty acid analogs
US4942231A (en) * 1984-05-24 1990-07-17 Mallinckrodt, Inc. Method of preparing a chlorinated, brominated, radio-brominated, iodinated and/or radioiodinated aromatic or heteroaromatic compound
EP0194843B1 (en) * 1985-03-11 1993-01-13 AMERSHAM INTERNATIONAL plc Complexes of technetium-99m with propylene amine oximes
US4746505A (en) * 1985-04-26 1988-05-24 President And Fellows Of Harvard College Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands
US4764358A (en) * 1985-04-30 1988-08-16 The United States Of America As Represented By The United States Department Of Energy Radiolabeled dimethyl branched long chain fatty acid for heart imaging
US4877599A (en) 1986-11-10 1989-10-31 New England Deaconess Hospital Corporation Detection of vascular disease with labelled antibodies
DE3880974T2 (de) * 1987-11-19 1993-08-26 Univ Vanderbilt Radiojodhaltige benzamide und verfahren zu ihrer verwendung als radiobildende agenzien.
US5242681A (en) * 1990-03-12 1993-09-07 Research Corporation Technologies, Inc. Lipophilic contrast agents for diagnostic image analysis
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
DE69636881T2 (de) * 1995-12-01 2007-09-20 Molecular Insight Pharmaceuticals, Inc., Cambridge Stereoisomere von fettsäureanalogen zur diagnostischen bildgebung
US7060251B1 (en) * 1997-09-08 2006-06-13 The General Hospital Corporation Imaging agents for early detection and monitoring of cardiovascular plaque
WO1999012579A1 (en) * 1997-09-08 1999-03-18 The General Hospital Corporation Imaging agents for early detection and monitoring of cardiovascular plaque
US6437103B1 (en) * 1999-04-14 2002-08-20 Biostream Inc. Fatty acid analogs for diagnosis of coronary artery disease
AU2001245862A1 (en) * 2000-03-21 2001-10-03 The Procter & Gamble Company Difluorobutyric acid metalloprotease inhibitors
AU2004232297B2 (en) * 2003-04-17 2010-11-04 The General Hospital Corporation Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid

Also Published As

Publication number Publication date
US20030215386A1 (en) 2003-11-20
US20070128110A1 (en) 2007-06-07
EP0869821A1 (en) 1998-10-14
WO1997019705A1 (en) 1997-06-05
DE69636881D1 (de) 2007-03-22
US7005119B2 (en) 2006-02-28
EP1767224A2 (en) 2007-03-28
ATE353019T1 (de) 2007-02-15
EP0869821B1 (en) 2007-01-31
HK1102262A1 (en) 2007-11-09
EP0869821A4 (en) 2002-08-28
US20080247948A1 (en) 2008-10-09
EP1767224B1 (en) 2011-10-05
DE69636881T2 (de) 2007-09-20
ATE526995T1 (de) 2011-10-15
EP1767224A3 (en) 2007-11-28
CA2238860A1 (en) 1997-06-05
US7314609B2 (en) 2008-01-01
JP2008201774A (ja) 2008-09-04
ES2374743T3 (es) 2012-02-21
HK1016494A1 (en) 1999-11-05
US20060078495A1 (en) 2006-04-13
JP4272259B2 (ja) 2009-06-03
JP2012036215A (ja) 2012-02-23
JP4937144B2 (ja) 2012-05-23
JP2000502059A (ja) 2000-02-22
ES2281906T3 (es) 2007-10-01

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Effective date: 20141125