CA2234367C - Compositions containing hydroperoxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders - Google Patents

Compositions containing hydroperoxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders Download PDF

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Publication number
CA2234367C
CA2234367C CA002234367A CA2234367A CA2234367C CA 2234367 C CA2234367 C CA 2234367C CA 002234367 A CA002234367 A CA 002234367A CA 2234367 A CA2234367 A CA 2234367A CA 2234367 C CA2234367 C CA 2234367C
Authority
CA
Canada
Prior art keywords
hete
alkyl
composition
dry eye
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002234367A
Other languages
English (en)
French (fr)
Other versions
CA2234367A1 (en
Inventor
John M. Yanni
Daniel A. Gamache
Steven T. Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Publication of CA2234367A1 publication Critical patent/CA2234367A1/en
Application granted granted Critical
Publication of CA2234367C publication Critical patent/CA2234367C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002234367A 1995-10-31 1996-08-19 Compositions containing hydroperoxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders Expired - Fee Related CA2234367C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/551,021 US5696166A (en) 1995-10-31 1995-10-31 Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders
US08/551,021 1995-10-31
PCT/US1996/013441 WO1997016179A1 (en) 1995-10-31 1996-08-19 Compositions containing hydroperoxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders

Publications (2)

Publication Number Publication Date
CA2234367A1 CA2234367A1 (en) 1997-05-09
CA2234367C true CA2234367C (en) 2002-06-04

Family

ID=24199512

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002234367A Expired - Fee Related CA2234367C (en) 1995-10-31 1996-08-19 Compositions containing hydroperoxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders

Country Status (12)

Country Link
US (1) US5696166A (2)
EP (1) EP0858330B1 (2)
JP (1) JPH11515024A (2)
AT (1) ATE198044T1 (2)
AU (1) AU706373B2 (2)
CA (1) CA2234367C (2)
DE (1) DE69611251T2 (2)
DK (1) DK0858330T3 (2)
ES (1) ES2152556T3 (2)
GR (1) GR3035438T3 (2)
PT (1) PT858330E (2)
WO (1) WO1997016179A1 (2)

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PT1228030E (pt) 1999-11-09 2005-08-31 Alcon Inc Derivados benzenoidicos do acido 15-hidroxieicosatetraenoico e metodos para a sua utilizacao no tratamento das perturbacoes do olho seco
HK1045985B (en) 1999-11-09 2004-04-23 Alcon, Inc. 15-hydroxyeicosatetraenoic acid-related compounds and methods of use
PT1228028E (pt) * 1999-11-09 2005-10-31 Alcon Inc Sais de hidroxieicosatetraeniato, composicoes e metodos para utilizacao no tratamento de perturbacoes da secura ocular
WO2001034550A2 (en) 1999-11-09 2001-05-17 Alcon Universal Ltd. 15-hydroxyeicosatetraenoic acid analogs with enhanced metabolic stability and methods of their use in treating dry eye disorders
DK1228027T3 (da) * 1999-11-09 2004-07-19 Alcon Inc 3-heteroatomsubstituerede og to carbonhomologe af 15-HETE og fremgangsmåder til anvendelse
DE60019322T2 (de) 1999-11-09 2005-09-08 Alcon Inc. Heteroatomunterbrochene analoge von15-hydroxyeicosatetraensäure und verfahren zu deren verwendung
US6803385B2 (en) 1999-11-09 2004-10-12 Alcon, Inc. Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
AU1226001A (en) 1999-11-09 2001-06-06 Alcon Universal Limited Phospholipids of hydroxyeicosatetraenoic acid-like derivatives
US6552084B2 (en) 1999-11-09 2003-04-22 Alcon Universal Ltd. Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
CA2386632A1 (en) 1999-11-09 2001-05-17 Alcon, Inc. Omega chain modified 15-hydroxyeicosatetraenoic acid derivatives and methods of their use for the treatment of dry eye
US6458854B2 (en) 1999-11-09 2002-10-01 Alcon Universal Ltd. Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use
PT1228032E (pt) * 1999-11-09 2004-10-29 Alcon Inc Composicoes contendo derivados do acido hidroxieicosatetraenoico e metodos de utilizacao para o tratamento de desordens do olho seco
DK1418167T3 (da) * 1999-11-09 2005-04-25 Alcon Inc Hydroxyicosatetraensyreanaloger og fremgangsmåder til deres anvendelse til behandling af öjentörhedslidelser
ATE258791T1 (de) * 1999-11-09 2004-02-15 Alcon Inc Lipoxin-a4 und deren analoge zur behandlung von trockenen augen
AU776254B2 (en) * 1999-11-09 2004-09-02 Alcon Inc. Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
AU2603301A (en) 1999-12-22 2001-07-03 Alcon Universal Limited 6-keto prostaglandin F1alpha and analogs for treating dry eye
US6277855B1 (en) * 2000-04-21 2001-08-21 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with nicotinic acetylcholine receptor agonists
AU2002224337A1 (en) * 2000-10-23 2002-05-06 Alcon, Inc. Use of hydroperoxyeicosatetraenoic acid derivatives following refractive surgery
DK1330246T3 (da) 2000-10-23 2005-08-08 Alcon Inc Anvendelse af hydroxyicosatetraensyrederivater ved intraokulær kirurgi
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
JP2004527578A (ja) 2001-05-21 2004-09-09 アルコン，インコーポレイテッド ドライアイ障害を処置するためのＮＦ−κＢインヒビターの使用
US6872382B1 (en) 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
BR0209883A (pt) 2001-05-21 2004-06-08 Alcon Inc Uso de inibidores da proteasoma para o tratamento de distúrbios do olho seco
US7112588B2 (en) * 2001-05-21 2006-09-26 Alcon, Inc. Use of proteasome inhibitors to treat dry eye disorders
EP1392322A1 (en) * 2001-05-21 2004-03-03 Alcon, Inc. Method of treating dry eye disorders
US6645994B1 (en) 2001-06-01 2003-11-11 Alcon, Inc. Method of treating dry eye disorders
US6750250B1 (en) 2001-07-12 2004-06-15 Alcon, Inc. 11,12-oxidoarachidonic acid derivatives and methods of their use in treating dry eye disorders
WO2003030892A1 (en) * 2001-10-11 2003-04-17 Alcon, Inc. Methods for treating dry eye
PL369960A1 (en) * 2001-10-11 2005-05-02 Alcon, Inc. Methods for treating dry eye by a combination of an antiinflammatory steroid and a muc-1 secretagogue
WO2003030894A1 (en) * 2001-10-11 2003-04-17 Alcon, Inc. Methods for treating dry eye
EP1583527A1 (en) * 2002-06-14 2005-10-12 Alcon, Inc. Use of hydroxyeicosatetraenoic acid compounds to treat ophthalmic inflammatory disorders
AU2003221707A1 (en) * 2002-06-14 2003-12-31 Alcon, Inc. Topical use of hydroxyeicosatetraenoic acid compounds to treat psoriasis
FR2843026B1 (fr) * 2002-08-02 2006-01-06 Goemar Lab Sa Nouveau medicament
EP1542768A1 (en) * 2002-09-20 2005-06-22 Alcon, Inc. Use of cytokine synthesis inhibitors for the treatment of dry eye disorders
US20040248794A1 (en) * 2002-12-20 2004-12-09 Yanni John M. Treatment of dry eye by restoring 15-lipoxygenase activity to ocular surface cells
WO2004093878A1 (en) 2003-04-16 2004-11-04 Alcon, Inc. Use of fused pyridazine derivatives for treating dry eye disorders
US20050202097A1 (en) * 2004-03-12 2005-09-15 Melbj Holdings, Llc, Florida Lubricant for the ocular surface
US8455016B2 (en) 2004-03-12 2013-06-04 Melbj Holdings, Llc Treatment for meibomian gland dysfunction or obstruction
DE602005017762D1 (de) * 2004-05-14 2009-12-31 Alcon Inc Methode zur behandlung trockener augen und uveitis
US7923471B2 (en) * 2004-05-14 2011-04-12 Alcon, Inc. Method of treating dry eye disorders and uveitis
US7223737B1 (en) 2004-08-13 2007-05-29 Alcon, Inc. Method of treating dry eye disorders using glycosides
WO2006022291A1 (ja) * 2004-08-27 2006-03-02 Senju Pharmaceutical Co, .Ltd. ドライアイ治療用点眼液
US20060128803A1 (en) * 2004-12-14 2006-06-15 Alcon, Inc. Method of treating dry eye disorders using 13(S)-HODE and its analogs
US7745461B1 (en) 2006-02-27 2010-06-29 Alcon Research, Ltd. Method of treating dry eye disorders
NZ582188A (en) * 2007-07-11 2012-03-30 Pfizer Pharmaceutical compositions and methods of treating dry eye disorders
US20090048368A1 (en) * 2007-08-13 2009-02-19 Bash Thomas F Polyolefin compositions comprising bio-based starch materials
JP5421272B2 (ja) * 2007-10-12 2014-02-19 リゾルヴィクス・ファーマシューティカルズ・インコーポレイテッド 眼病治療のための組成物及び方法
AU2014201375B2 (en) * 2007-10-12 2015-11-05 Resolvyx Pharmaceuticals, Inc. Omega-3 fatty acids, hydroxy polyunsaturated fatty acids, lipoxin compounds, or oxylipin compounds for the treatment of ophthalmic conditions
US20090098136A1 (en) * 2007-10-15 2009-04-16 Alcon Research, Ltd. Use of tnf receptor antagonists for treating dry eye
TW200927192A (en) * 2007-11-19 2009-07-01 Alcon Res Ltd Use of TRPV1 receptor antagonists for treating dry eye and ocular pain
US8207226B1 (en) 2008-06-03 2012-06-26 Alcon Research, Ltd. Use of FAAH antagonists for treating dry eye and ocular pain
GB0907413D0 (en) 2009-04-29 2009-06-10 Equateq Ltd Novel methods
EP2496233A1 (en) * 2009-11-06 2012-09-12 Alcon Research, Ltd. Nutritional supplements for relief of dry eye
JP2016538288A (ja) * 2013-11-15 2016-12-08 ディグニティ サイエンシス リミテッド 多価不飽和ヒドロキシ脂肪酸の薬学的に許容される塩
CN109311976A (zh) 2016-06-20 2019-02-05 诺华股份有限公司 使用TNFα拮抗剂治疗干眼症的方法
US20210315851A1 (en) 2020-04-03 2021-10-14 Afimmune Limited Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases

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Also Published As

Publication number Publication date
DE69611251D1 (de) 2001-01-18
GR3035438T3 (en) 2001-05-31
EP0858330A1 (en) 1998-08-19
DK0858330T3 (da) 2001-01-02
ES2152556T3 (es) 2001-02-01
PT858330E (pt) 2001-03-30
AU6851696A (en) 1997-05-22
CA2234367A1 (en) 1997-05-09
WO1997016179A1 (en) 1997-05-09
HK1013194A1 (en) 1999-08-20
ATE198044T1 (de) 2000-12-15
JPH11515024A (ja) 1999-12-21
EP0858330B1 (en) 2000-12-13
US5696166A (en) 1997-12-09
AU706373B2 (en) 1999-06-17
DE69611251T2 (de) 2001-04-05

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