CA2230896A1 - Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions - Google Patents
Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions Download PDFInfo
- Publication number
- CA2230896A1 CA2230896A1 CA002230896A CA2230896A CA2230896A1 CA 2230896 A1 CA2230896 A1 CA 2230896A1 CA 002230896 A CA002230896 A CA 002230896A CA 2230896 A CA2230896 A CA 2230896A CA 2230896 A1 CA2230896 A1 CA 2230896A1
- Authority
- CA
- Canada
- Prior art keywords
- ethyl
- carboxylate
- mmol
- aminocitraconamido
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US310995P | 1995-09-01 | 1995-09-01 | |
US60/003,109 | 1995-12-18 | ||
US08/574,406 US5852028A (en) | 1995-12-18 | 1995-12-18 | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
US08/574,406 | 1995-12-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2230896A1 true CA2230896A1 (en) | 1997-03-13 |
Family
ID=26671335
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002230896A Abandoned CA2230896A1 (en) | 1995-09-01 | 1996-08-30 | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPH11512390A (ja) |
AU (1) | AU726058B2 (ja) |
CA (1) | CA2230896A1 (ja) |
WO (1) | WO1997009325A1 (ja) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6245774B1 (en) | 1994-06-21 | 2001-06-12 | Celltech Therapeutics Limited | Tri-substituted phenyl or pyridine derivatives |
US5935966A (en) * | 1995-09-01 | 1999-08-10 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
US5939421A (en) * | 1997-07-01 | 1999-08-17 | Signal Pharmaceuticals, Inc. | Quinazoline analogs and related compounds and methods for treating inflammatory conditions |
ATE245641T1 (de) * | 1998-02-17 | 2003-08-15 | Tularik Inc | Antivirale pyrimidinderivate |
WO2000005234A1 (fr) | 1998-07-22 | 2000-02-03 | Suntory Limited | INHIBITEURS DE NF-λB CONTENANT DES DERIVES D'INDANE EN TANT QU'INGREDIENT ACTIF |
ATE267175T1 (de) | 1998-08-27 | 2004-06-15 | Sumitomo Pharma | Pyrimidin derivate |
GB9914258D0 (en) * | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
WO2001021206A1 (fr) * | 1999-09-17 | 2001-03-29 | Suntory Limited | MOYENS DE PREVENTION OU REMEDES CONTRE LA MYOCARDITE, LA CARDIOMYOPATHIE DILATEE ET L'INSUFFISANCE CARDIAQUE CONTENANT DES INHIBITEURS NF-λB EN TANT QU'INGREDIENT ACTIF |
JP4922539B2 (ja) | 2000-09-15 | 2012-04-25 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼインヒビターとして有用なピラゾール化合物 |
US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
NZ526470A (en) | 2000-12-21 | 2006-03-31 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors |
CA2443487A1 (en) | 2001-04-13 | 2002-10-24 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
EP1392300A1 (en) * | 2001-05-11 | 2004-03-03 | Vertex Pharmaceuticals Incorporated | 2,5-disubstituted pyridine, pyrimidine, pyridazine and 1, 2, 4-triazine derivatives for use as p38 inhibitors |
RS94703A (en) | 2001-05-29 | 2007-02-05 | Schering Aktiengesellschaft, | Cdk inhibiting pyrimidines, production thereof and their use as medicaments |
SE0104140D0 (sv) | 2001-12-07 | 2001-12-07 | Astrazeneca Ab | Novel Compounds |
MY141867A (en) | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
AU2003257078B2 (en) | 2002-08-02 | 2010-04-01 | Vertex Pharmaceuticals Incorporated | Pyrazole compositions useful as inhibitors of GSK-3 |
CA2571710A1 (en) | 2004-06-24 | 2006-11-02 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
MX2007009843A (es) | 2005-02-16 | 2007-08-23 | Astrazeneca Ab | Compuestos quimicos. |
JP2008540622A (ja) | 2005-05-16 | 2008-11-20 | アストラゼネカ アクチボラグ | 化合物 |
DK1945631T3 (da) | 2005-10-28 | 2012-10-22 | Astrazeneca Ab | 4- (3-aminopyrazole) pyrimidinderivater til anvendelse som tyrosinkinaseinhibitorer til behandling af cancer |
EP1951715B1 (en) | 2005-11-03 | 2013-09-04 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
GB0524427D0 (en) * | 2005-11-30 | 2006-01-11 | 7Tm Pharma As | Use of receptor ligands in threapy |
JP5498703B2 (ja) | 2006-01-23 | 2014-05-21 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用なチオフェン−カルボキサミド |
JP2009533452A (ja) | 2006-04-13 | 2009-09-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼの阻害剤として有用なチオフェン−カルボキサミド |
CA2653005A1 (en) | 2006-05-23 | 2007-12-06 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
CN101484447A (zh) | 2006-05-23 | 2009-07-15 | 沃泰克斯药物股份有限公司 | 可用作蛋白激酶抑制剂的噻吩-甲酰胺类 |
US8258129B2 (en) * | 2006-07-06 | 2012-09-04 | Boehringer Ingelheim International Gmbh | 4-heterocycloalkylpyri(mi)dines, process for the preparation thereof and their use as medicaments |
EP4074704A1 (en) | 2007-04-11 | 2022-10-19 | CanBas Co., Ltd. | Quinoline compounds with anti-cancer activity |
EP2152694A2 (en) | 2007-05-02 | 2010-02-17 | Vertex Pharmaceuticals Incorporated | Thiazoles and pyrazoles useful as kinase inhibitors |
UA99459C2 (en) | 2007-05-04 | 2012-08-27 | Астразенека Аб | 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer |
AU2008282156B2 (en) | 2007-07-31 | 2014-07-17 | Vertex Pharmaceuticals Incorporated | Process for preparing 5-fluoro-1H-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof |
EP2323622A1 (en) | 2008-09-03 | 2011-05-25 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical formulations comprising the same |
JPWO2010113834A1 (ja) * | 2009-03-30 | 2012-10-11 | アステラス製薬株式会社 | ピリミジン化合物 |
CN108148003B (zh) * | 2018-01-16 | 2021-03-26 | 棓诺(苏州)新材料有限公司 | Oled材料中间体苯甲酰嘧啶类化合物的合成方法 |
CN117180122B (zh) * | 2023-11-02 | 2024-04-09 | 杭州湃肽生化科技有限公司 | 一种舒敏修复组合物及其应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4983608A (en) * | 1989-09-05 | 1991-01-08 | Hoechst-Roussell Pharmaceuticals, Inc. | N-substituted-4-pyrimidinamines and pyrimidinediamines |
-
1996
- 1996-08-30 AU AU70130/96A patent/AU726058B2/en not_active Ceased
- 1996-08-30 WO PCT/US1996/014089 patent/WO1997009325A1/en active Application Filing
- 1996-08-30 CA CA002230896A patent/CA2230896A1/en not_active Abandoned
- 1996-08-30 JP JP9511324A patent/JPH11512390A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO1997009325A1 (en) | 1997-03-13 |
AU7013096A (en) | 1997-03-27 |
JPH11512390A (ja) | 1999-10-26 |
AU726058B2 (en) | 2000-10-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |