CA2224225A1 - Process for the synthesis of vinyl sulfenic acid derivatives - Google Patents

Process for the synthesis of vinyl sulfenic acid derivatives Download PDF

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Publication number
CA2224225A1
CA2224225A1 CA002224225A CA2224225A CA2224225A1 CA 2224225 A1 CA2224225 A1 CA 2224225A1 CA 002224225 A CA002224225 A CA 002224225A CA 2224225 A CA2224225 A CA 2224225A CA 2224225 A1 CA2224225 A1 CA 2224225A1
Authority
CA
Canada
Prior art keywords
alkyl
compound
hydrogen
formula
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002224225A
Other languages
English (en)
French (fr)
Inventor
Wayne Douglas Luke
David Warren Hoard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/482,692 external-priority patent/US5512701A/en
Priority claimed from US08/483,607 external-priority patent/US5514826A/en
Application filed by Individual filed Critical Individual
Publication of CA2224225A1 publication Critical patent/CA2224225A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/16—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/08—Sulfenic acids; Derivatives thereof
    • C07C313/18—Sulfenamides
    • C07C313/20—Sulfenamides having sulfur atoms of sulfenamide groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0834—Compounds having one or more O-Si linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CA002224225A 1995-06-07 1996-06-04 Process for the synthesis of vinyl sulfenic acid derivatives Abandoned CA2224225A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/482,692 US5512701A (en) 1995-06-07 1995-06-07 Process for the synthesis of vinyl sulfenic acid derivatives
US08/482,692 1995-06-07
US08/483,607 US5514826A (en) 1995-06-07 1995-06-07 Vinyl sulfenic acid derivatives
US08/483,607 1995-06-07

Publications (1)

Publication Number Publication Date
CA2224225A1 true CA2224225A1 (en) 1996-12-19

Family

ID=27047368

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002224225A Abandoned CA2224225A1 (en) 1995-06-07 1996-06-04 Process for the synthesis of vinyl sulfenic acid derivatives

Country Status (16)

Country Link
EP (1) EP0830362A4 (pt)
JP (1) JPH11507346A (pt)
KR (1) KR19990022503A (pt)
CN (2) CN1068883C (pt)
AU (1) AU698076B2 (pt)
BR (1) BR9608847A (pt)
CA (1) CA2224225A1 (pt)
CZ (1) CZ387997A3 (pt)
EA (1) EA000606B1 (pt)
HU (1) HUP9900923A3 (pt)
IL (1) IL122127A (pt)
NO (1) NO975633L (pt)
NZ (1) NZ310241A (pt)
PL (1) PL323907A1 (pt)
TR (1) TR199701511T1 (pt)
WO (1) WO1996040693A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG106558A1 (en) * 1995-06-07 2004-10-29 Lilly Co Eli Vinyl sulfoxides and a process for their synthesis
EP0830361A4 (en) * 1995-06-07 1998-12-30 Lilly Co Eli VINYLSULFOXIDES AND METHOD FOR THEIR SYNTHESIS
EP1546138B1 (en) 2002-09-30 2012-01-18 A/S GEA Farmaceutisk Fabrik Raloxifene l-lactate or a hemihydrate thereof, their uses, pharmaceutical compositions and preparation processes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL65379A0 (en) * 1981-04-03 1982-05-31 Lilly Co Eli Process for preparing acylated benzothiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
DE3543567A1 (de) * 1985-12-10 1987-06-11 Degussa Verfahren zur herstellung von sulfensaeurechloriden und sulfensaeureestern

Also Published As

Publication number Publication date
HUP9900923A3 (en) 2000-02-28
EP0830362A4 (en) 1998-09-02
HUP9900923A2 (hu) 1999-07-28
CN1192215A (zh) 1998-09-02
EA000606B1 (ru) 1999-12-29
JPH11507346A (ja) 1999-06-29
TR199701511T1 (xx) 1998-04-21
BR9608847A (pt) 1999-06-08
AU6100396A (en) 1996-12-30
AU698076B2 (en) 1998-10-22
IL122127A (en) 2001-05-20
NO975633D0 (no) 1997-12-04
MX9709130A (es) 1998-03-31
NZ310241A (en) 1999-07-29
CN1330071A (zh) 2002-01-09
CN1068883C (zh) 2001-07-25
IL122127A0 (en) 1998-04-05
EA199800026A1 (ru) 1998-06-25
PL323907A1 (en) 1998-04-27
NO975633L (no) 1998-01-28
EP0830362A1 (en) 1998-03-25
WO1996040693A1 (en) 1996-12-19
CZ387997A3 (cs) 1998-09-16
KR19990022503A (ko) 1999-03-25

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Legal Events

Date Code Title Description
FZDE Discontinued