CA2221991C - Di- and trivalent small molecule selectin inhibitors - Google Patents

Di- and trivalent small molecule selectin inhibitors Download PDF

Info

Publication number
CA2221991C
CA2221991C CA002221991A CA2221991A CA2221991C CA 2221991 C CA2221991 C CA 2221991C CA 002221991 A CA002221991 A CA 002221991A CA 2221991 A CA2221991 A CA 2221991A CA 2221991 C CA2221991 C CA 2221991C
Authority
CA
Canada
Prior art keywords
bis
mmol
mannopyranosyloxy
carboxymethylphenyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002221991A
Other languages
English (en)
French (fr)
Other versions
CA2221991A1 (en
Inventor
Timothy P. Kogan
Brian Dupre
Ian L. Scott
Huong Bui
Kathy L. Wheeler
Karin M. Keller
Jamal M. Kassir
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Encysive Pharmaceuticals Inc
Original Assignee
BIOTECHNOLOGY Corp
Texas Biotechnology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIOTECHNOLOGY Corp, Texas Biotechnology Corp filed Critical BIOTECHNOLOGY Corp
Publication of CA2221991A1 publication Critical patent/CA2221991A1/en
Application granted granted Critical
Publication of CA2221991C publication Critical patent/CA2221991C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • External Artificial Organs (AREA)
CA002221991A 1995-06-29 1996-06-26 Di- and trivalent small molecule selectin inhibitors Expired - Fee Related CA2221991C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US53395P 1995-06-29 1995-06-29
US278495P 1995-06-29 1995-06-29
US60/002,784 1995-06-29
US60/000,533 1995-06-29
PCT/US1996/011032 WO1997001335A1 (en) 1995-06-29 1996-06-26 Di- and trivalent small molecule selectin inhibitors

Publications (2)

Publication Number Publication Date
CA2221991A1 CA2221991A1 (en) 1997-01-16
CA2221991C true CA2221991C (en) 2007-09-18

Family

ID=26667782

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002221991A Expired - Fee Related CA2221991C (en) 1995-06-29 1996-06-26 Di- and trivalent small molecule selectin inhibitors

Country Status (21)

Country Link
EP (1) EP0840606B1 (Sortimente)
JP (1) JP4046351B2 (Sortimente)
KR (1) KR100438136B1 (Sortimente)
CN (1) CN1149082C (Sortimente)
AT (1) ATE193647T1 (Sortimente)
AU (1) AU704596B2 (Sortimente)
BR (1) BR9608873A (Sortimente)
CA (1) CA2221991C (Sortimente)
CZ (1) CZ290072B6 (Sortimente)
DE (1) DE69608804T2 (Sortimente)
DK (1) DK0840606T3 (Sortimente)
ES (1) ES2146886T3 (Sortimente)
FI (1) FI974618A7 (Sortimente)
GR (1) GR3034289T3 (Sortimente)
HU (1) HU224590B1 (Sortimente)
NO (1) NO310623B1 (Sortimente)
PL (1) PL185372B1 (Sortimente)
PT (1) PT840606E (Sortimente)
RU (1) RU2165931C2 (Sortimente)
UA (1) UA52607C2 (Sortimente)
WO (1) WO1997001335A1 (Sortimente)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1020944C (zh) * 1990-01-30 1993-05-26 阿图尔-费希尔股份公司费希尔厂 紧固件
WO1998031697A1 (en) * 1997-01-15 1998-07-23 Sankyo Company, Limited Aryl c-glycoside compounds and sulfated esters thereof
WO1999029706A2 (en) * 1997-12-08 1999-06-17 Glycomed Incorporated DISALICYLATE ANALOG BASED SIALYL LEWISx MIMETICS
IL141654A0 (en) * 1998-09-04 2002-03-10 Byk Gulden Lomberg Chem Fab Pyranose derivatives and pharmaceutical compositions containing the same
PH12000002657B1 (en) 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
GB9924990D0 (en) * 1999-10-21 1999-12-22 Glaxo Group Ltd Medicaments
US6683056B2 (en) 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
US6555519B2 (en) 2000-03-30 2003-04-29 Bristol-Myers Squibb Company O-glucosylated benzamide SGLT2 inhibitors and method
US6936590B2 (en) 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
WO2003097658A2 (en) 2002-05-16 2003-11-27 Glycomimetics, Inc. Compounds and methods for inhibiting selectin-mediated function
DE602004011272T2 (de) 2003-11-19 2008-12-24 Glycomimetics, Inc. Spezifischer antagonist sowohl für e- als auch p-selektine
EP1577289A1 (en) 2004-03-18 2005-09-21 Revotar Biopharmaceuticals AG Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders
DK1928892T3 (da) 2005-08-09 2012-01-30 Glycomimetics Inc Glycomimetiske inhibitorer af PA-IL-lectin PA-IIL-lectin eller begge lectiner fra pseudomonas
ES2397850T3 (es) 2005-09-02 2013-03-11 Glycomimetics, Inc. Inhibidores de pan-selectina heterobifuncionales
EP1764095A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel nitrocatechol derivatives having selectin ligand activity
EP1764093A1 (en) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel aromatic compounds and their use in medical applications
EP1764096A1 (en) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel phloroglucinol derivatives having selectin ligand activity
KR100827674B1 (ko) * 2006-05-23 2008-05-07 (주)한빛테크 자동트립 장치와 그 제어방법
EP1897533A1 (en) * 2006-09-08 2008-03-12 Revotar Biopharmaceuticals AG Use of 1,6-Bis [3-(3-carboxymethylphenyl)-4-(2-alpha -D-mannopyranosyl-oxy)-phenyl] hexane for the preparation of cosmetic compositions
EP1903049A1 (en) * 2006-09-08 2008-03-26 Revotar Biopharmaceuticals AG Crystalline forms of 1,6-Bis [3-(3-carboxymethylphenyl)-4-(2-alpha -D-mannopyranosyloxy)-phenyl] hexane
EP1958637A1 (en) * 2007-02-14 2008-08-20 Revotar Biopharmaceuticals AG Pharmaceutical composition for the treatment of IL-8 mediated diseases
US8217064B2 (en) 2007-12-20 2012-07-10 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
US8895510B2 (en) 2008-04-08 2014-11-25 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
CA2798383A1 (en) 2010-05-07 2011-11-10 Revotar Biopharmaceuticals Ag Process for the preparation of bimosiamose
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
CN104039805B (zh) 2011-12-22 2016-11-16 糖模拟物有限公司 E-选择蛋白拮抗剂化合物、组合物及使用方法
SI2928476T1 (en) 2012-12-07 2018-06-29 Glycomimetics, Inc. COMPONENTS, INSTALLATIONS AND PROCEDURES OF THE APPLICATION OF E-SELECTINE OF ANTAGONISTS FOR THE MOBILIZATION OF HEMATOPOETIC CELLS
JP6689854B2 (ja) 2014-12-03 2020-04-28 グリコミメティクス， インコーポレイテッド Ｅ−セレクチンおよびｃｘｃｒ４ケモカイン受容体のヘテロ二官能性阻害剤
WO2018031445A1 (en) 2016-08-08 2018-02-15 Glycomimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4
JP7272956B2 (ja) 2017-03-15 2023-05-12 グリコミメティクス， インコーポレイテッド Ｅ－セレクチンアンタゴニストとしてのガラクトピラノシル－シクロヘキシル誘導体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH19293A (en) * 1982-11-15 1986-03-04 Pfizer Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
AU610160B2 (en) * 1987-05-06 1991-05-16 Adir Et Compagnie New macrolide derivatives, process for the preparation thereof and pharmaceutical compositions containing them
US5075289A (en) * 1988-06-07 1991-12-24 Abbott Laboratories 9-r-azacyclic erythromycin antibiotics
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
KR950700314A (ko) * 1992-01-31 1995-01-16 아키라 하세가와 루이스형 당쇄 유도체(Lewis-type sugar chain derivative)
US5444050A (en) * 1994-04-29 1995-08-22 Texas Biotechnology Corporation Binding of E-selectin or P-selectin to sialyl Lewisx or sialyl-Lewisa
US5498775A (en) * 1994-11-07 1996-03-12 American Home Products Corporation Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation

Also Published As

Publication number Publication date
PL185372B1 (pl) 2003-04-30
AU6292396A (en) 1997-01-30
NO310623B1 (no) 2001-07-30
EP0840606A4 (Sortimente) 1998-05-13
DE69608804T2 (de) 2000-11-02
PT840606E (pt) 2000-11-30
CZ290072B6 (cs) 2002-05-15
CA2221991A1 (en) 1997-01-16
NO976074L (no) 1998-03-02
RU2165931C2 (ru) 2001-04-27
NO976074D0 (no) 1997-12-23
HUP9802602A3 (en) 1999-08-30
ATE193647T1 (de) 2000-06-15
KR100438136B1 (ko) 2004-08-25
ES2146886T3 (es) 2000-08-16
FI974618L (fi) 1997-12-23
JPH11508885A (ja) 1999-08-03
CZ407597A3 (cs) 1998-07-15
HU224590B1 (hu) 2005-11-28
PL324330A1 (en) 1998-05-25
UA52607C2 (uk) 2003-01-15
DK0840606T3 (da) 2000-08-07
CN1149082C (zh) 2004-05-12
GR3034289T3 (en) 2000-12-29
KR19990028441A (ko) 1999-04-15
EP0840606A1 (en) 1998-05-13
JP4046351B2 (ja) 2008-02-13
AU704596B2 (en) 1999-04-29
WO1997001335A1 (en) 1997-01-16
CN1196678A (zh) 1998-10-21
EP0840606B1 (en) 2000-06-07
BR9608873A (pt) 1999-07-06
DE69608804D1 (de) 2000-07-13
FI974618A0 (fi) 1997-12-23
HUP9802602A2 (hu) 1999-02-01
FI974618A7 (fi) 1997-12-23

Similar Documents

Publication Publication Date Title
CA2221991C (en) Di- and trivalent small molecule selectin inhibitors
US5919768A (en) Di- and trivalent small molecule selectin inhibitors
US5444050A (en) Binding of E-selectin or P-selectin to sialyl Lewisx or sialyl-Lewisa
US5622937A (en) Compositions and methods of inhibiting the binding of E-selectin or P-selectin or sialyl-Lewisx or sialyl-Lewisa
AU707160B2 (en) Tetrahydronaphthalene derivatives and their therapeutic use
US5789385A (en) Sialyl Lewisx mimetics containing phenyl backbones
JPWO2001068660A1 (ja) グルコピラノシルオキシベンジルベンゼン誘導体、それを含有する医薬組成物およびその製造中間体
JP2001288178A (ja) Ｃ−配糖体及びその製造方法並びにこれを含有する薬剤
WO2014094544A1 (zh) 含脱氧葡萄糖结构的苯基c-葡萄糖苷衍生物及其制备方法和用途
CN103270033B (zh) C-芳基葡糖苷衍生物及其制备方法和应用
FR2465731A1 (fr) Derives de type desoxy-2 o-demethyl-3 des fortimicines a et b, utiles notamment comme medicaments antibiotiques
EP0153392A1 (en) Poly-cation salts of 4-o-polyhexaose-thio-arylene sulfates
TW457246B (en) Dimeric small molecule selectin inhibitors comprising of (mannopyranosyloxy)biphenyl-substituted carboxylic acid
MXPA96004849A (en) Link of e-selectine, p-selectine or l-selectine with sialil-lewis (x) or sialil-lewis

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20140626