CA2221318C - High affinity oligonucleotide ligands to growth factors - Google Patents
High affinity oligonucleotide ligands to growth factors Download PDFInfo
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- CA2221318C CA2221318C CA2221318A CA2221318A CA2221318C CA 2221318 C CA2221318 C CA 2221318C CA 2221318 A CA2221318 A CA 2221318A CA 2221318 A CA2221318 A CA 2221318A CA 2221318 C CA2221318 C CA 2221318C
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- C07K14/475—Growth factors; Growth regulators
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- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/458,424 | 1995-06-02 | ||
| US08/458,423 US5731144A (en) | 1990-06-11 | 1995-06-02 | High affinity TGFβ nucleic acid ligands |
| US08/458,424 US5731424A (en) | 1990-06-11 | 1995-06-02 | High affinity TGFβ nucleic acid ligands and inhibitors |
| US08/458,423 | 1995-06-02 | ||
| US08/465,594 US5846713A (en) | 1990-06-11 | 1995-06-05 | High affinity HKGF nucleic acid ligands and inhibitors |
| US08/465,594 | 1995-06-05 | ||
| US08/465,591 | 1995-06-05 | ||
| US08/465,591 US5837834A (en) | 1990-06-11 | 1995-06-05 | High affinity HKGF nucleic acid ligands and inhibitors |
| US08/479,783 US5668264A (en) | 1990-06-11 | 1995-06-07 | High affinity PDGF nucleic acid ligands |
| US08/479,783 | 1995-06-07 | ||
| US08/479,725 | 1995-06-07 | ||
| US08/479,725 US5674685A (en) | 1990-06-11 | 1995-06-07 | High affinity PDGF nucleic acid ligands |
| US08/618,693 | 1996-03-20 | ||
| US08/618,693 US5723594A (en) | 1995-06-07 | 1996-03-20 | High affinity PDGF nucleic acid ligands |
| PCT/US1996/008014 WO1996038579A1 (en) | 1995-06-02 | 1996-05-30 | High-affinity oligonucleotide ligands to growth factors |
Publications (2)
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| CA2221318A1 CA2221318A1 (en) | 1996-12-05 |
| CA2221318C true CA2221318C (en) | 2012-01-24 |
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| CA2221318A Expired - Lifetime CA2221318C (en) | 1995-06-02 | 1996-05-30 | High affinity oligonucleotide ligands to growth factors |
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| EP (2) | EP1741780A3 (enExample) |
| JP (2) | JP4531132B2 (enExample) |
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| DE (1) | DE69636656T2 (enExample) |
| ES (1) | ES2276405T3 (enExample) |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8853376B2 (en) | 2002-11-21 | 2014-10-07 | Archemix Llc | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
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| US6346611B1 (en) * | 1990-06-11 | 2002-02-12 | Gilead Sciences, Inc. | High affinity TGfβ nucleic acid ligands and inhibitors |
| US6395888B1 (en) * | 1996-02-01 | 2002-05-28 | Gilead Sciences, Inc. | High affinity nucleic acid ligands of complement system proteins |
| US6344321B1 (en) * | 1990-06-11 | 2002-02-05 | Gilead Sciences, Inc. | Nucleic acid ligands which bind to hepatocyte growth factor/scatter factor (HGF/SF) or its receptor c-met |
| US6229002B1 (en) | 1995-06-07 | 2001-05-08 | Nexstar Pharmaceuticlas, Inc. | Platelet derived growth factor (PDGF) nucleic acid ligand complexes |
| US6242246B1 (en) | 1997-12-15 | 2001-06-05 | Somalogic, Inc. | Nucleic acid ligand diagnostic Biochip |
| AU2004242462B2 (en) * | 1999-07-29 | 2008-01-24 | Gilead Sciences, Inc. | Nucleic acid ligands to hepatocyte growth factor/scatter factor (HGF/SF) or its receptor C-Met and to integrins |
| PT1401853E (pt) | 2001-05-25 | 2010-12-07 | Univ Duke | Modulador de oligonucleotídeos |
| US7879991B2 (en) * | 2002-05-06 | 2011-02-01 | Noxxon Pharma Ag | CGRP binding nucleic acids |
| GB0213745D0 (en) | 2002-06-14 | 2002-07-24 | Univ Edinburgh | Enzyme |
| US20040249130A1 (en) * | 2002-06-18 | 2004-12-09 | Martin Stanton | Aptamer-toxin molecules and methods for using same |
| CA2487809A1 (en) * | 2002-06-18 | 2003-12-24 | Archemix Corp. | Aptamer-toxin molecules and methods for using same |
| US10100316B2 (en) * | 2002-11-21 | 2018-10-16 | Archemix Llc | Aptamers comprising CPG motifs |
| US20050124565A1 (en) * | 2002-11-21 | 2005-06-09 | Diener John L. | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| US8039443B2 (en) * | 2002-11-21 | 2011-10-18 | Archemix Corporation | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| US20040253243A1 (en) * | 2003-01-21 | 2004-12-16 | David Epstein | Aptamer therapeutics useful in ocular pharmacotherapy |
| EP2623601B1 (en) | 2003-04-21 | 2015-02-18 | Archemix LLC | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| US20040219663A1 (en) * | 2003-04-30 | 2004-11-04 | Page Robert D. | Biopolymer array fabrication using different drop deposition heads |
| US7727969B2 (en) * | 2003-06-06 | 2010-06-01 | Massachusetts Institute Of Technology | Controlled release nanoparticle having bound oligonucleotide for targeted delivery |
| PL1660057T3 (pl) | 2003-08-27 | 2012-10-31 | Ophthotech Corp | Terapia łączona do leczenia zaburzeń związanych z neowaskularyzacją gałki ocznej |
| PL3385384T3 (pl) | 2004-02-12 | 2021-03-08 | Archemix Llc | Aptamerowe środki terapeutyczne użyteczne w leczeniu zaburzeń powiązanych z dopełniaczem |
| US7803931B2 (en) | 2004-02-12 | 2010-09-28 | Archemix Corp. | Aptamer therapeutics useful in the treatment of complement-related disorders |
| US20060193821A1 (en) * | 2004-03-05 | 2006-08-31 | Diener John L | Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics |
| RU2006135119A (ru) * | 2004-03-05 | 2008-04-10 | Аркемикс Корп. (Us) | Аптамеры к семейству цитокинов il-12 человека и их применение в качестве лекарственных средств для аутоиммунных заболеваний |
| US20080214489A1 (en) * | 2004-04-19 | 2008-09-04 | Anthony Dominic Keefe | Aptamer-mediated intracellular delivery of oligonucleotides |
| US7579450B2 (en) * | 2004-04-26 | 2009-08-25 | Archemix Corp. | Nucleic acid ligands specific to immunoglobulin E and their use as atopic disease therapeutics |
| MX2007002772A (es) | 2004-09-07 | 2008-03-05 | Archemix Corp | Aptameros para el factor de von willebrand y su uso como agentes terapeuticos para la enfermedad trombotica. |
| EP1791557A4 (en) * | 2004-09-07 | 2009-09-23 | Archemix Corp | MEDICAL CHEMISTRY USING APTAMERS |
| US7566701B2 (en) * | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
| EP3034089A1 (en) | 2004-11-02 | 2016-06-22 | Archemix LLC | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| WO2006100449A1 (en) | 2005-03-19 | 2006-09-28 | Medical Research Council | Improvements in or relating to treatment and prevention of viral infections |
| US8101385B2 (en) | 2005-06-30 | 2012-01-24 | Archemix Corp. | Materials and methods for the generation of transcripts comprising modified nucleotides |
| AU2006265896B2 (en) | 2005-06-30 | 2012-05-31 | Archemix Corp. | Materials and methods for the generation of fully 2'-modified nucleic acid transcripts |
| CA2626325A1 (en) | 2005-10-28 | 2007-05-10 | Praecis Pharmaceuticals Incorporated | Methods for identifying compounds of interest using encoded libraries |
| US7922000B2 (en) * | 2006-02-15 | 2011-04-12 | Miraial Co., Ltd. | Thin plate container with a stack of removable loading trays |
| HUE026496T2 (en) * | 2006-03-08 | 2016-06-28 | Archemix Llc | Complement-binding aptamers and anti-C5 agents for treating eye diseases |
| WO2008134077A1 (en) * | 2007-04-30 | 2008-11-06 | Archemix Corp. | Metabolic profile directed aptamer medicinal chemistry |
| US20090203766A1 (en) * | 2007-06-01 | 2009-08-13 | Archemix Corp. | vWF aptamer formulations and methods for use |
| US20080305157A1 (en) * | 2007-06-08 | 2008-12-11 | University Of Maryland Office Of Technology Commercialization | Encapsulation and separation of charged organic solutes inside catanionic vesicles |
| US20090233295A1 (en) * | 2008-01-29 | 2009-09-17 | Elias Georges | Trim59 directed diagnostics for neoplastic disease |
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1996
- 1996-05-30 WO PCT/US1996/008014 patent/WO1996038579A1/en not_active Ceased
- 1996-05-30 EP EP06021052A patent/EP1741780A3/en not_active Withdrawn
- 1996-05-30 AU AU58839/96A patent/AU732820B2/en not_active Expired
- 1996-05-30 CA CA2221318A patent/CA2221318C/en not_active Expired - Lifetime
- 1996-05-30 ES ES96920573T patent/ES2276405T3/es not_active Expired - Lifetime
- 1996-05-30 AT AT96920573T patent/ATE343638T1/de not_active IP Right Cessation
- 1996-05-30 EP EP96920573A patent/EP0828849B1/en not_active Expired - Lifetime
- 1996-05-30 JP JP53664696A patent/JP4531132B2/ja not_active Expired - Lifetime
- 1996-05-30 US US08/973,124 patent/US6207816B1/en not_active Expired - Lifetime
- 1996-05-30 DE DE69636656T patent/DE69636656T2/de not_active Expired - Lifetime
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2002
- 2002-08-19 US US10/223,666 patent/US20030180744A1/en not_active Abandoned
-
2006
- 2006-05-31 US US11/444,181 patent/US20060229273A1/en not_active Abandoned
- 2006-09-14 JP JP2006249182A patent/JP2007049997A/ja active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8853376B2 (en) | 2002-11-21 | 2014-10-07 | Archemix Llc | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
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| EP1741780A3 (en) | 2007-03-28 |
| EP0828849A1 (en) | 1998-03-18 |
| EP0828849A4 (en) | 2005-01-19 |
| EP0828849B1 (en) | 2006-10-25 |
| JP2001500362A (ja) | 2001-01-16 |
| WO1996038579A1 (en) | 1996-12-05 |
| DE69636656D1 (de) | 2006-12-07 |
| EP1741780A2 (en) | 2007-01-10 |
| CA2221318A1 (en) | 1996-12-05 |
| JP2007049997A (ja) | 2007-03-01 |
| ATE343638T1 (de) | 2006-11-15 |
| JP4531132B2 (ja) | 2010-08-25 |
| AU5883996A (en) | 1996-12-18 |
| ES2276405T3 (es) | 2007-06-16 |
| US6207816B1 (en) | 2001-03-27 |
| AU732820B2 (en) | 2001-05-03 |
| US20030180744A1 (en) | 2003-09-25 |
| US20060229273A1 (en) | 2006-10-12 |
| DE69636656T2 (de) | 2007-10-04 |
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