CA2214899C - Procede de preparation de glucane et applications therapeutiques du glucane - Google Patents

Procede de preparation de glucane et applications therapeutiques du glucane Download PDF

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Publication number
CA2214899C
CA2214899C CA002214899A CA2214899A CA2214899C CA 2214899 C CA2214899 C CA 2214899C CA 002214899 A CA002214899 A CA 002214899A CA 2214899 A CA2214899 A CA 2214899A CA 2214899 C CA2214899 C CA 2214899C
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CA
Canada
Prior art keywords
glucan
treatment
skin
use according
ulcers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002214899A
Other languages
English (en)
Other versions
CA2214899A1 (fr
Inventor
Graham Edmund Kelly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TR THERAPEUTICS Inc
Original Assignee
Novogen Research Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPN1661A external-priority patent/AUPN166195A0/en
Application filed by Novogen Research Pty Ltd filed Critical Novogen Research Pty Ltd
Priority to CA002562918A priority Critical patent/CA2562918C/fr
Publication of CA2214899A1 publication Critical patent/CA2214899A1/fr
Application granted granted Critical
Publication of CA2214899C publication Critical patent/CA2214899C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof

Abstract

L'invention a pour objet un procédé de production de beta -(1,3)(1,6) glucane à partir d'une source cellulaire contenant du glucane. L'invention traite également de compositions et des applications/méthodes de traitement mettant en oeuvre le glucane. Le procédé selon l'invention comprend les étapes consistant: (a) à extraire les cellules contenant du glucane à l'aide d'alcali et en les chauffant, afin de retirer les compsants solubles à l'alcali; (b) à extraire à l'acide les cellules de l'étape (a) à l'aide d'un acide et en les chauffant pour former une suspension; (c) à extraire la suspension obtenue à l'étape (b); ou les cellules hydrolysées extraites, à l'aide d'un solvant organique non miscible à l'eau et dont la densité est supérieure à celle de l'eau, et séparer la phase aqueuse obtenue, la phase contenant le solvant et l'interface de sorte que l'on obtient uniquement la phase aqueuse comprenant la matière particulaire de beta -(1,3)(1,6) glucane. Selon ce procédé, l'extraction à l'aide du solvent organique assure la séparation des sous-groupes de glucane comprenant du beta -(1,3)(1,6) glucane ramifié, et essentiellement du beta -(1,3) glucane non ramifié qui est associé aux contaminants résiduaires autre que le glucane. Le procédé comprend enfin l'étape (d) consistant à sécher la matière de glucane obtenue à l'étape (c) pour donner du glucane microparticulaire.
CA002214899A 1995-03-13 1996-03-13 Procede de preparation de glucane et applications therapeutiques du glucane Expired - Fee Related CA2214899C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002562918A CA2562918C (fr) 1995-03-13 1996-03-13 Procede de preparation de glucane et applications therapeutiques du glucane

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPN1661A AUPN166195A0 (en) 1995-03-13 1995-03-13 Process for glucan extraction
AUPN1661 1995-03-13
PCT/AU1996/000138 WO1996028476A1 (fr) 1995-03-13 1996-03-13 Procede de preparation de glucane et applications therapeutiques du glucane

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002562918A Division CA2562918C (fr) 1995-03-13 1996-03-13 Procede de preparation de glucane et applications therapeutiques du glucane

Publications (2)

Publication Number Publication Date
CA2214899A1 CA2214899A1 (fr) 1996-09-19
CA2214899C true CA2214899C (fr) 2007-01-02

Family

ID=37603360

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002214899A Expired - Fee Related CA2214899C (fr) 1995-03-13 1996-03-13 Procede de preparation de glucane et applications therapeutiques du glucane

Country Status (1)

Country Link
CA (1) CA2214899C (fr)

Also Published As

Publication number Publication date
CA2214899A1 (fr) 1996-09-19

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