CA2211324A1 - Alpha-foetoproteine humaine recombinante et ses utilisations - Google Patents

Alpha-foetoproteine humaine recombinante et ses utilisations

Info

Publication number
CA2211324A1
CA2211324A1 CA002211324A CA2211324A CA2211324A1 CA 2211324 A1 CA2211324 A1 CA 2211324A1 CA 002211324 A CA002211324 A CA 002211324A CA 2211324 A CA2211324 A CA 2211324A CA 2211324 A1 CA2211324 A1 CA 2211324A1
Authority
CA
Canada
Prior art keywords
fetoprotein
human alpha
cell
recombinant human
mammal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002211324A
Other languages
English (en)
Other versions
CA2211324C (fr
Inventor
Robert A. Murgita
Richard Boismenu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merrimack Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/377,309 external-priority patent/US5965528A/en
Priority claimed from US08/505,012 external-priority patent/US6331611B1/en
Application filed by Individual filed Critical Individual
Publication of CA2211324A1 publication Critical patent/CA2211324A1/fr
Application granted granted Critical
Publication of CA2211324C publication Critical patent/CA2211324C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4715Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32Antioestrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)

Abstract

De façon générale, on divulgue des méthodes pour inhiber la prolifération des cellules immunitaires autoréactives chez un mammifère, comportant l'administration au mammifère d'une quantité thérapeutiquement efficace d'une alpha-foetoprotéine humaine recombinante ou d'un fragment anti-prolifération des cellules immunitaires ou d'un analogue de cette dernière; des méthodes pour inhiber un néoplasme chez un mammifère, comportant l'administration au mammifère d'une quantité thérapeutiquement efficace d'une alpha-foetoprotéine humaine recombinante ou d'un fragment anti-néoplasme ou d'un analogue de cette dernière; ainsi que des méthodes de culture cellulaire, comportant l'utilisation d'un milieu contenant de l'alpha-foetoprotéine humaine ou un fragment ou un analogue de cette dernière.
CA2211324A 1995-01-24 1996-01-24 Alpha-foetoproteine humaine recombinante et ses utilisations Expired - Lifetime CA2211324C (fr)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US37731695A 1995-01-24 1995-01-24
US37731195A 1995-01-24 1995-01-24
US37731795A 1995-01-24 1995-01-24
US08/377,309 1995-01-24
US08/377,311 1995-01-24
US08/377,317 1995-01-24
US08/377,309 US5965528A (en) 1991-09-27 1995-01-24 Recombinant human alph-fetoprotein as an immunosuppressive agent
US08/377,316 1995-01-24
US08/505,012 1995-07-21
US08/505,012 US6331611B1 (en) 1991-09-27 1995-07-21 Expression and purification of cloned human alpha-fetoprotein
PCT/US1996/000996 WO1996022787A1 (fr) 1995-01-24 1996-01-24 Alpha-f×toproteine humaine recombinante et ses utilisations

Publications (2)

Publication Number Publication Date
CA2211324A1 true CA2211324A1 (fr) 1996-08-01
CA2211324C CA2211324C (fr) 2012-07-10

Family

ID=27541364

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2211324A Expired - Lifetime CA2211324C (fr) 1995-01-24 1996-01-24 Alpha-foetoproteine humaine recombinante et ses utilisations

Country Status (7)

Country Link
EP (1) EP0805687A4 (fr)
JP (2) JPH10513347A (fr)
CN (1) CN1150030C (fr)
AU (1) AU700975B2 (fr)
CA (1) CA2211324C (fr)
HK (1) HK1010153A1 (fr)
WO (1) WO1996022787A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965528A (en) 1991-09-27 1999-10-12 Mcgill University Recombinant human alph-fetoprotein as an immunosuppressive agent
US6288034B1 (en) 1995-01-24 2001-09-11 Martinex R & D Inc. Recombinant human alpha-fetoprotein as an immunosuppressive agent
WO1998035981A1 (fr) * 1997-02-13 1998-08-20 The Regents Of The University Of California Prevention et traitement du cancer hepatocellulaire
WO2001058922A2 (fr) * 2000-02-10 2001-08-16 The Regents Of The University Of California Methodes et compositions destinees au traitement du cancer hepatocellulaire
US7098306B2 (en) 1997-02-13 2006-08-29 The Regents Of The University Of California Method and compositions for treating hepatocellular cancer
EP1958503A3 (fr) * 1999-01-06 2008-11-26 Merrimack Pharmaceuticals, Inc. Expression d'alpha féto-protéines humaines secrétées dans des animaux transgéniques
US7208576B2 (en) 1999-01-06 2007-04-24 Merrimack Pharmaceuticals, Inc. Non-glycosylated human alpha-fetoprotein, methods of production, and uses thereof
WO2001003501A2 (fr) * 1999-07-12 2001-01-18 Universite Libre De Bruxelles Mammifere non humain genetiquement modifie presentant une carence d'alpha-foetoproteine
US7022892B1 (en) 1999-07-12 2006-04-04 Universite Libre De Bruxelles Non-human genetically modified mammal lacking the alpha-fetoprotein
FI118263B (fi) * 2002-10-09 2007-09-14 Timo Kalevi Korpela Kaspaasiaktiivisuutta säätelevät peptidit
US7074561B2 (en) * 2002-10-22 2006-07-11 Biomerieux, Inc. Isothermal amplification based assay for the detection and quantitation of alpha-fetoprotein mRNA
EP1789066A4 (fr) * 2004-09-09 2009-10-28 Serometrix Llc Compositions et methodes d'utilisation de peptides inhibiteurs de la croissance de l'alpha-fetoproteine
US8932829B2 (en) 2005-07-07 2015-01-13 Elena Dudich Recombinant alpha-fetoprotein and compositions thereof
GB0617564D0 (en) * 2006-09-06 2006-10-18 Ucl Business Plc Peptides and methods
CN101743018A (zh) * 2006-12-19 2010-06-16 梅里麦克药品公司 甲胎蛋白和免疫调谐剂的共同施用以治疗多发性硬化
WO2008113970A2 (fr) * 2007-03-16 2008-09-25 Ucl Business Plc Peptides
CN105732795A (zh) * 2016-03-21 2016-07-06 海南医学院 一种获得人类甲胎蛋白的方法
CN112898399A (zh) * 2019-12-03 2021-06-04 香雪生命科学技术(广东)有限公司 源自于afp抗原的短肽
CN113416729B (zh) * 2021-05-18 2022-11-22 遵义医科大学附属医院 一种肝脏靶向调控甲胎蛋白基因的shRNA和cDNA及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5486602A (en) * 1977-10-27 1979-07-10 Hoffmann La Roche Production of purified alpha 1 phetoprotein
JPH025866A (ja) * 1988-06-27 1990-01-10 Kansai Shin Gijutsu Kenkyusho:Kk ヒトアルファフェトプロテインドメインi遺伝子、対応プラスミド組換体、対応形質転換体、該ドメインiの製造法及び製造された該ドメインi
IT1226551B (it) * 1988-07-29 1991-01-24 Sclavo Spa Peptide sintetico immunologicamente attivo capace di indurre la produzione di anticorpi con elevata specificita' verso l'alfa- fetoproteina e loro impiego in campo diagnostico
EP0356399A3 (fr) * 1988-08-26 1991-03-20 Sandoz Ag Dérivés substitués du 4-azatricyclo (22.3.1.04.9) octacos-18-ène, leur préparation et les compositions pharmaceutiques les contenant
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
US5206153A (en) * 1990-06-27 1993-04-27 Snow Brand Milk Products Co., Ltd. Method of producing human α-fetoprotein and product produced thereby
WO1993005774A1 (fr) * 1991-09-25 1993-04-01 Wisconsin Alumni Research Foundation Complexes d'antibiotiques d'anthracycline et d'acides gras polyinsatures dans des emulsions de lipides
CA2120131A1 (fr) * 1991-09-27 1994-05-11 Robert A. Murgita Expression et purification d'alphafoetoproteine humaine clonee
DE59509887D1 (de) * 1994-09-26 2002-01-10 Infineon Technologies Ag Koppelanordnung zum optischen aneinanderkoppeln eines oeic-bausteins und optischer fasern

Also Published As

Publication number Publication date
EP0805687A1 (fr) 1997-11-12
CA2211324C (fr) 2012-07-10
JPH10513347A (ja) 1998-12-22
AU4903596A (en) 1996-08-14
HK1010153A1 (en) 1999-06-17
AU700975B2 (en) 1999-01-14
JP2008073041A (ja) 2008-04-03
WO1996022787A1 (fr) 1996-08-01
CN1179106A (zh) 1998-04-15
EP0805687A4 (fr) 2000-05-31
CN1150030C (zh) 2004-05-19

Similar Documents

Publication Publication Date Title
CA2211324A1 (fr) Alpha-foetoproteine humaine recombinante et ses utilisations
Casey et al. Purification of bacterially expressed single chain Fv antibodies for clinical applications using metal chelate chromatography
AU725238B2 (en) Antigen binding fragments that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers
FI103181B (fi) Uusi vasta-aine ja siihen liittyvät vasta-ainekonjugaatit, DNA-sekvens sit, ilmentämisvehikkelit ja solut
CA2287872A1 (fr) Compositions immunogenes dirigees contre le recepteur de cck-b/gastrine et procede de traitement des tumeurs
EP0334165A2 (fr) Anticorps monoclonaux
JPH05184384A (ja) hBNPのC端を認識するモノクロ−ナル抗体
KR20200143366A (ko) 수식 항체 및 방사성 금속 표지 항체
US6355444B1 (en) Carcinoma associated antigen (SK1) monoclonal antibodies against SK1, methods of producing these antibodies and uses therefor
CA2343979A1 (fr) Interleukine humaine b50, ses utilisations therapeutiques
US6403096B1 (en) Vasopermeability enhancing peptide of human interleukin-2 and immunoconjugates thereof
CA2240409A1 (fr) Genes de chemokine cx3c mammalienne
AU722904B2 (en) Novel polynucleotides PANC1A and PANC1B associated with pancreatic cancer
WO1998008866B1 (fr) Bau, une proteine interactive associee a la sequence bin1, et utilisations
US5496705A (en) Monoclonal antibody specific for rat synaptophysin
AU596670B2 (en) Assays and antibodies for n-myc proteins
Lam Treatment of B-cell lymphoma using peptides. A novel concept.
Greiner et al. Modulation of human tumor antigen expression
CN109593131B (zh) 一种抗14-3-3η蛋白单克隆抗体及其用途
Rathjen et al. Selective enhancement of tumour necrosis factor activity: mapping regions with monoclonal antibodies
EP0931836B1 (fr) Peptide dérivé de l'interleukine-2 humaine pouvant accroître la perméablilté vasculaire et les immunoconjugués en dérivant
JPH11508235A (ja) 腫瘍関連エピトープ
US20040156824A1 (en) Vasopermeability enhancing peptide of human interleukin-2 and immunoconjugates thereof
JPH03163095A (ja) ヒト神経成長因子の部分ペプチド、抗体およびその用途
Ozker Current developments in single photon radiopharmaceuticals for tumor imaging

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20160125