IT1226551B - Peptide sintetico immunologicamente attivo capace di indurre la produzione di anticorpi con elevata specificita' verso l'alfa- fetoproteina e loro impiego in campo diagnostico - Google Patents

Peptide sintetico immunologicamente attivo capace di indurre la produzione di anticorpi con elevata specificita' verso l'alfa- fetoproteina e loro impiego in campo diagnostico

Info

Publication number
IT1226551B
IT1226551B IT8821553A IT2155388A IT1226551B IT 1226551 B IT1226551 B IT 1226551B IT 8821553 A IT8821553 A IT 8821553A IT 2155388 A IT2155388 A IT 2155388A IT 1226551 B IT1226551 B IT 1226551B
Authority
IT
Italy
Prior art keywords
phetoprotein
antibodies
inducing
production
synthetic peptide
Prior art date
Application number
IT8821553A
Other languages
English (en)
Other versions
IT8821553A0 (it
Inventor
Mario Felice Tecce
Marzia Monica Giuliani
Stefano Ricci
Giulio Ratti
Benedetto Terrana
Original Assignee
Sclavo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sclavo Spa filed Critical Sclavo Spa
Priority to IT8821553A priority Critical patent/IT1226551B/it
Publication of IT8821553A0 publication Critical patent/IT8821553A0/it
Priority to EP19890201926 priority patent/EP0353814A3/en
Priority to US07/384,411 priority patent/US5130415A/en
Priority to JP1194432A priority patent/JPH02218694A/ja
Application granted granted Critical
Publication of IT1226551B publication Critical patent/IT1226551B/it
Priority to US07/835,278 priority patent/US5206164A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Reproductive Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IT8821553A 1988-07-29 1988-07-29 Peptide sintetico immunologicamente attivo capace di indurre la produzione di anticorpi con elevata specificita' verso l'alfa- fetoproteina e loro impiego in campo diagnostico IT1226551B (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT8821553A IT1226551B (it) 1988-07-29 1988-07-29 Peptide sintetico immunologicamente attivo capace di indurre la produzione di anticorpi con elevata specificita' verso l'alfa- fetoproteina e loro impiego in campo diagnostico
EP19890201926 EP0353814A3 (en) 1988-07-29 1989-07-21 Synthetic peptide endowed with immunological activity, capable of inducing the production of antibodies with a high specificity towards alpha-fetoprotein, and their use in the diagnostic field
US07/384,411 US5130415A (en) 1988-07-29 1989-07-24 Synthetic peptide endowed with immunological activity, capable of inducing the production of antibodies with a high specificity towards alpha-fetoprotein, and their use in the diagnostic field
JP1194432A JPH02218694A (ja) 1988-07-29 1989-07-28 合成ペプチド
US07/835,278 US5206164A (en) 1988-07-29 1992-02-13 DNA encoding a synthetic peptide endowed with immunological activity and capable of inducing the production of antibodies with a high specificity towards alpha-fetoprotein

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8821553A IT1226551B (it) 1988-07-29 1988-07-29 Peptide sintetico immunologicamente attivo capace di indurre la produzione di anticorpi con elevata specificita' verso l'alfa- fetoproteina e loro impiego in campo diagnostico

Publications (2)

Publication Number Publication Date
IT8821553A0 IT8821553A0 (it) 1988-07-29
IT1226551B true IT1226551B (it) 1991-01-24

Family

ID=11183514

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8821553A IT1226551B (it) 1988-07-29 1988-07-29 Peptide sintetico immunologicamente attivo capace di indurre la produzione di anticorpi con elevata specificita' verso l'alfa- fetoproteina e loro impiego in campo diagnostico

Country Status (4)

Country Link
US (1) US5130415A (it)
EP (1) EP0353814A3 (it)
JP (1) JPH02218694A (it)
IT (1) IT1226551B (it)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE901427A1 (en) * 1990-07-23 1991-11-06 Prendergast Patrick T Treatment for viral interference
GB9101550D0 (en) * 1991-01-24 1991-03-06 Mastico Robert A Antigen-presenting chimaeric protein
US6288034B1 (en) 1995-01-24 2001-09-11 Martinex R & D Inc. Recombinant human alpha-fetoprotein as an immunosuppressive agent
US5965528A (en) * 1991-09-27 1999-10-12 Mcgill University Recombinant human alph-fetoprotein as an immunosuppressive agent
US6331611B1 (en) 1991-09-27 2001-12-18 Mcgill University Expression and purification of cloned human alpha-fetoprotein
JPH05339295A (ja) * 1991-12-05 1993-12-21 Agency Of Ind Science & Technol 抗体の作成方法
US5652352A (en) * 1994-03-31 1997-07-29 Amgen Inc. Afamin: a human serum albumin-like gene
US6534479B1 (en) 1995-01-24 2003-03-18 Martinex R & D Inc. Recombinant alpha-fetoprotein hybrid cytotoxins for treating and diagnosing cancers
JPH10513347A (ja) * 1995-01-24 1998-12-22 ロバート エイ． マルギタ 組換え型ヒトα−フェトプロテインおよびその利用
US7101837B1 (en) 1995-01-24 2006-09-05 Martinex R & D Inc. Recombinant human alpha-fetoprotein as a cell proliferative agent
US6011052A (en) * 1996-04-30 2000-01-04 Warner-Lambert Company Pyrazolone derivatives as MCP-1 antagonists
US7098306B2 (en) * 1997-02-13 2006-08-29 The Regents Of The University Of California Method and compositions for treating hepatocellular cancer
WO1998035981A1 (en) * 1997-02-13 1998-08-20 The Regents Of The University Of California Prevention and treatment of hepatocellular cancer
US7208576B2 (en) 1999-01-06 2007-04-24 Merrimack Pharmaceuticals, Inc. Non-glycosylated human alpha-fetoprotein, methods of production, and uses thereof
US6242219B1 (en) * 1999-03-18 2001-06-05 Xoma (Us) Llc Methods for recombinant peptide production
EP1253930A4 (en) * 2000-02-10 2003-05-21 Univ California METHODS AND COMPOSITIONS FOR TREATING HEPATOCELLULAR CANCER
FI118263B (fi) * 2002-10-09 2007-09-14 Timo Kalevi Korpela Kaspaasiaktiivisuutta säätelevät peptidit
EP1584680A1 (en) * 2004-04-08 2005-10-12 Boehringer Ingelheim Austria GmbH Fed-batch fermentation process for the production of plasmid DNA
US8932829B2 (en) 2005-07-07 2015-01-13 Elena Dudich Recombinant alpha-fetoprotein and compositions thereof
US20100304873A1 (en) * 2009-05-28 2010-12-02 Lipa Markowitz Bowling Ball and Football Game Controller
CN115894683B (zh) * 2022-12-22 2023-08-04 山东纳睿博恩生物医药科技有限公司 检测甲胎蛋白的单克隆抗体及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4223002A (en) * 1978-08-28 1980-09-16 Hoffmann-La Roche Inc. Isolation of alpha1 -fetoprotein
EP0351458A1 (en) * 1988-07-21 1990-01-24 SCLAVO S.p.A. Process for preparing human alpha-foetoprotein
FR2635267B1 (fr) * 1988-08-09 1992-05-22 Tokuyama Soda Kk Anticorps monoclonaux et procede pour les produire

Also Published As

Publication number Publication date
EP0353814A2 (en) 1990-02-07
US5130415A (en) 1992-07-14
EP0353814A3 (en) 1991-10-09
JPH02218694A (ja) 1990-08-31
IT8821553A0 (it) 1988-07-29

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