CA2198389C - Triphenylethylenes for the prevention and treatment of osteoporosis - Google Patents

Triphenylethylenes for the prevention and treatment of osteoporosis Download PDF

Info

Publication number
CA2198389C
CA2198389C CA002198389A CA2198389A CA2198389C CA 2198389 C CA2198389 C CA 2198389C CA 002198389 A CA002198389 A CA 002198389A CA 2198389 A CA2198389 A CA 2198389A CA 2198389 C CA2198389 C CA 2198389C
Authority
CA
Canada
Prior art keywords
compound
estrogen
compounds
osteoporosis
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002198389A
Other languages
English (en)
French (fr)
Other versions
CA2198389A1 (en
Inventor
Michael Degregorio
Lauri Veikko Matti Kangas
Pirkko Harkonen
Kalervo Vaananen
Aire Laine
Valerie Wiebe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Orion Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtyma Oy filed Critical Orion Yhtyma Oy
Publication of CA2198389A1 publication Critical patent/CA2198389A1/en
Application granted granted Critical
Publication of CA2198389C publication Critical patent/CA2198389C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Materials For Photolithography (AREA)
CA002198389A 1994-09-07 1995-09-06 Triphenylethylenes for the prevention and treatment of osteoporosis Expired - Lifetime CA2198389C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9418067A GB9418067D0 (en) 1994-09-07 1994-09-07 Triphenylethylenes for the prevention and treatment of osteoporosis
GB9418067.6 1994-09-07
PCT/FI1995/000475 WO1996007402A1 (en) 1994-09-07 1995-09-06 Triphenylethylenes for the prevention and treatment of osteoporosis

Publications (2)

Publication Number Publication Date
CA2198389A1 CA2198389A1 (en) 1996-03-14
CA2198389C true CA2198389C (en) 2007-02-20

Family

ID=10761007

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002198389A Expired - Lifetime CA2198389C (en) 1994-09-07 1995-09-06 Triphenylethylenes for the prevention and treatment of osteoporosis

Country Status (17)

Country Link
US (2) US5750576A (sv)
EP (1) EP0779808B1 (sv)
JP (1) JP3910211B2 (sv)
AT (1) ATE183389T1 (sv)
CA (1) CA2198389C (sv)
DE (1) DE69511566T2 (sv)
DK (1) DK0779808T3 (sv)
ES (1) ES2135083T3 (sv)
FI (1) FI118755B (sv)
GB (1) GB9418067D0 (sv)
GR (1) GR3031109T3 (sv)
IL (1) IL115171A (sv)
NO (1) NO315785B1 (sv)
NZ (1) NZ291836A (sv)
SI (1) SI0779808T1 (sv)
WO (1) WO1996007402A1 (sv)
ZA (1) ZA957481B (sv)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504074A (en) * 1993-08-06 1996-04-02 Children's Medical Center Corporation Estrogenic compounds as anti-angiogenic agents
GB9609171D0 (en) 1996-05-02 1996-07-03 Orion Yhtymae Oy Antioxidant compounds
AU6959898A (en) * 1997-04-11 1998-11-11 David J. Grainger Compounds and therapies for the prevention of vascular and non-vascular pathol ogies
GB9803521D0 (en) * 1998-02-19 1998-04-15 Orion Yhtymo Oy New compounds and pharmaceutical compositions thereof
US20040176470A1 (en) * 1998-05-07 2004-09-09 Steiner Mitchell S. Method for treatment and chemoprevention of prostate cancer
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
EP1705169A3 (en) * 1999-11-16 2006-11-15 Hormos Medical Ltd. Triphenylalkene derivatives and their use as selective estrogen receptor modulators
TW593256B (en) * 1999-11-16 2004-06-21 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
US6245819B1 (en) * 2000-07-21 2001-06-12 Hormos Medical Oy, Ltd. Method for the treatment of vaginal dryness and sexual dysfunction in women during or after the menopause
US20060269611A1 (en) * 2001-11-29 2006-11-30 Steiner Mitchell S Prevention and treatment of androgen-deprivation induced osteoporosis
US20080249183A1 (en) * 2001-11-29 2008-10-09 Steiner Mitchell S Treatment of androgen-deprivation induced osteoporosis
US20050080143A1 (en) * 2001-11-29 2005-04-14 Steiner Mitchell S. Treatment of androgen-deprivation induced osteoporosis
US20040214898A1 (en) * 2001-11-29 2004-10-28 Steiner Mitchell S. Methods for treating hot flashes
US20040248989A1 (en) 2003-06-05 2004-12-09 Risto Santti Method for the treatment or prevention of lower urinary tract symptoms
US8236861B2 (en) 2004-02-13 2012-08-07 Hormos Medical Corporation Method for enhancing the bioavailablity of ospemifene
US20050187302A1 (en) * 2004-02-23 2005-08-25 Hormos Medical Corporation Method for treatment or prevention of osteoporosis in individuals with high bone turnover
US8642079B2 (en) 2004-02-23 2014-02-04 Hormos Medical Corporation Solid formulations of ospemifene
US8758821B2 (en) 2004-05-04 2014-06-24 Hormos Medical Ltd. Oral formulations of ospemifene
AU2005237274B2 (en) 2004-05-04 2011-02-17 Hormos Medical Ltd Novel oral formulations of ospemifene
US20060293294A1 (en) * 2004-09-03 2006-12-28 Hormos Medical Corporation Method for treatment or prevention of androgen deficiency
US20060270641A1 (en) * 2005-05-31 2006-11-30 Steiner Mitchell S Method for chemoprevention of prostate cancer
US9409856B2 (en) 2005-11-28 2016-08-09 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US8158828B2 (en) 2005-11-28 2012-04-17 Gtx, Inc. Nuclear receptor binding agents
US8637706B2 (en) 2005-11-28 2014-01-28 Gtx, Inc. Nuclear receptor binding agents
US8546451B2 (en) 2005-11-28 2013-10-01 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
MX2008014825A (es) 2006-05-22 2008-12-01 Hormos Medical Ltd Moduladores selectivos del receptor de estrogeno o inhibidores de aromatasa para tratar prostatitis cronica no bacteriana.
US20080176255A1 (en) * 2007-01-23 2008-07-24 Edward Sobek Mold detection composition and methods
SI2121553T1 (sl) 2007-02-14 2012-11-30 Hormos Medical Ltd Postopek za pripravo terapevtsko uporabnih trifenilbutenskih derivatov
US7504530B2 (en) 2007-02-14 2009-03-17 Hormos Medical Ltd. Methods for the preparation of fispemifene from ospemifene
US20080312239A1 (en) * 2007-06-13 2008-12-18 Quatrx Pharmaceuticals Company Methods for the treatment of erectile dysfunction using fispemifene
US9624161B2 (en) 2009-02-23 2017-04-18 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US9427418B2 (en) 2009-02-23 2016-08-30 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
KR101149529B1 (ko) 2009-09-11 2012-05-25 한국화학연구원 인덴온 유도체 및 이를 포함하는 약학적 조성물
EP2526080B1 (en) 2010-01-19 2014-03-26 Cambrex Karlskoga AB New processes for producing benzophenone derivatives
WO2014060640A1 (en) 2012-10-19 2014-04-24 Fermion Oy A process for the preparation of ospemifene
US9321712B2 (en) 2012-10-19 2016-04-26 Fermion Oy Process for the preparation of ospemifene
CN103739456A (zh) * 2013-12-03 2014-04-23 镇江圣安医药有限公司 2-（对-（（z-4-氯-1,2-二苯基-1-丁烯基）苯氧基）乙醇的新型衍生物及其应用
EP3240771B1 (en) 2014-12-29 2019-02-20 OLON S.p.A. Process for the preparation of ospemifene and fispemifene
WO2016110805A1 (en) * 2015-01-09 2016-07-14 Glenmark Pharmaceuticals Limited Process for preparation of ospemifene
ES2960344T3 (es) 2015-03-10 2024-03-04 Shionogi Inc Dispersiones sólidas que comprenden ospemifeno
KR102052133B1 (ko) 2017-08-10 2019-12-05 고려대학교 산학협력단 당 부가된 오스페미펜, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물
GR1009542B (el) 2018-04-25 2019-06-07 Φαρματεν Α.Β.Ε.Ε. Καψουλα μαλακης γελης που περιλαμβανει εναν εκλεκτικο ρυθμιστη οιστρογονικων υποδοχεων
KR20220115062A (ko) 2021-02-09 2022-08-17 (주)오스티오뉴로젠 크로몬 구조의 화합물을 포함하는 골다공증의 예방 및 치료용 약학적 조성물

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9207437D0 (en) * 1992-04-03 1992-05-20 Orion Yhtymae Oy Topical administration of toremifene and its metabolites

Also Published As

Publication number Publication date
EP0779808B1 (en) 1999-08-18
NO971037L (no) 1997-04-29
JPH10505079A (ja) 1998-05-19
NO971037D0 (no) 1997-03-06
SI0779808T1 (en) 1999-10-31
AU699845B2 (en) 1998-12-17
GB9418067D0 (en) 1994-10-26
ES2135083T3 (es) 1999-10-16
DE69511566D1 (de) 1999-09-23
CA2198389A1 (en) 1996-03-14
FI970920A0 (sv) 1997-03-04
FI118755B (sv) 2008-03-14
EP0779808A1 (en) 1997-06-25
AU3347895A (en) 1996-03-27
GR3031109T3 (en) 1999-12-31
ZA957481B (en) 1996-04-09
NO315785B1 (no) 2003-10-27
NZ291836A (en) 1998-06-26
JP3910211B2 (ja) 2007-04-25
DE69511566T2 (de) 2000-04-27
WO1996007402A1 (en) 1996-03-14
US5912273A (en) 1999-06-15
FI970920A (sv) 1997-03-04
ATE183389T1 (de) 1999-09-15
IL115171A0 (en) 1995-12-31
US5750576A (en) 1998-05-12
DK0779808T3 (da) 2000-03-13
IL115171A (en) 2001-08-26

Similar Documents

Publication Publication Date Title
CA2198389C (en) Triphenylethylenes for the prevention and treatment of osteoporosis
CN100441556C (zh) 三苯基烯烃衍生物和它们作为选择性雌激素受体调制剂的用途
CA2195093C (en) Use of droloxifene for the treatment of prostatic diseases, endometriosis and obesity
JP5629746B2 (ja) 閉経期または閉経後の女性における更年期障害の治療方法
MXPA02000075A (es) Metodos de tratamiento y/o supresion del incremento de peso.
JPH08231540A (ja) エストロゲン作動薬
CA2928173C (en) Compositions comprising benzothiophene derivatives and use thereof for treatment of estrogen-related medical disorders
NO336612B1 (no) Anvendelse av en forbindelse for fremstilling av en farmasøytisk sammensetning for hemming av urininkontinens i en kvinne
US5389646A (en) Methods for treatment and prevention of bone loss using 2,3-benzopyrans
AU699845C (en) Triphenylethylenes for the prevention and treatment of osteoporosis
JP2002503713A (ja) Ｅ−２−［４−（４−クロロ−１，２−ジフェニル−ブテ−１−エニル）フェノキシ］エタノールおよびその医薬組成物
Gauthier et al. Synthesis and structure–activity relationships of analogs of EM-652 (acolbifene), a pure selective estrogen receptor modulator. Study of nitrogen substitution
EP2363132B1 (en) Sophoricoside for use in the treatment of cartilage degeneration
Sorbera et al. CP-336156
WO2008060397A2 (en) Method of treating thermoregulatory disfunction
AU709606B2 (en) Use of droloxifene for the treatment of prostatic diseases endometriosis and obesity
Faggiano et al. Uncommon clinical course of multiple osteochondromatosis in a patient with a long-term history of Cushing's disease
Inoue et al. Therapeutic Value of Mepitiostane in the Treatment of Advanced Breast Cancer 1, 2
Blazej et al. Selective Estrogen Receptor Modulators. Current and Future Treatment Options for Osteoporosis
O'Regan et al. SERMS OTHER THAN
Kulshrestha et al. Asian Journal of Organic & Medicinal Chemistry

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20150908