ES2135083T3 - Trifeniletilenos para la prevencion y el tratamiento de la osteoporosis. - Google Patents

Trifeniletilenos para la prevencion y el tratamiento de la osteoporosis.

Info

Publication number
ES2135083T3
ES2135083T3 ES95929903T ES95929903T ES2135083T3 ES 2135083 T3 ES2135083 T3 ES 2135083T3 ES 95929903 T ES95929903 T ES 95929903T ES 95929903 T ES95929903 T ES 95929903T ES 2135083 T3 ES2135083 T3 ES 2135083T3
Authority
ES
Spain
Prior art keywords
osteoporosis
prevention
treatment
tryphenylethylene
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95929903T
Other languages
English (en)
Inventor
Michael Degregorio
Lauri Veikko Matti Kangas
Pirkko Harkonen
Kalervo Vaananen
Aire Laine
Valerie Wiebe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Orion Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtyma Oy filed Critical Orion Yhtyma Oy
Application granted granted Critical
Publication of ES2135083T3 publication Critical patent/ES2135083T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Materials For Photolithography (AREA)

Abstract

COMPUESTOS QUE TIENEN LA FORMULA (I) EN LA QUE R 1 R SUB,2} SON INDEPENDIENTEMENTE H O OH, Y QUE SON UTILES PARA EL TRATAMIENTO Y PREVENCION DE LA OSTEOPOROSIS. LOS COMPUESTOS DE LA FORMULA (I) CARECEN DE ACTIVIDAD ANTIESTROGENICA Y ESTROGENICA SIGNIFICATIVA.
ES95929903T 1994-09-07 1995-09-06 Trifeniletilenos para la prevencion y el tratamiento de la osteoporosis. Expired - Lifetime ES2135083T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9418067A GB9418067D0 (en) 1994-09-07 1994-09-07 Triphenylethylenes for the prevention and treatment of osteoporosis

Publications (1)

Publication Number Publication Date
ES2135083T3 true ES2135083T3 (es) 1999-10-16

Family

ID=10761007

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95929903T Expired - Lifetime ES2135083T3 (es) 1994-09-07 1995-09-06 Trifeniletilenos para la prevencion y el tratamiento de la osteoporosis.

Country Status (17)

Country Link
US (2) US5750576A (es)
EP (1) EP0779808B1 (es)
JP (1) JP3910211B2 (es)
AT (1) ATE183389T1 (es)
CA (1) CA2198389C (es)
DE (1) DE69511566T2 (es)
DK (1) DK0779808T3 (es)
ES (1) ES2135083T3 (es)
FI (1) FI118755B (es)
GB (1) GB9418067D0 (es)
GR (1) GR3031109T3 (es)
IL (1) IL115171A (es)
NO (1) NO315785B1 (es)
NZ (1) NZ291836A (es)
SI (1) SI0779808T1 (es)
WO (1) WO1996007402A1 (es)
ZA (1) ZA957481B (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504074A (en) * 1993-08-06 1996-04-02 Children's Medical Center Corporation Estrogenic compounds as anti-angiogenic agents
GB9609171D0 (en) * 1996-05-02 1996-07-03 Orion Yhtymae Oy Antioxidant compounds
WO1998046588A2 (en) 1997-04-11 1998-10-22 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
GB9803521D0 (en) * 1998-02-19 1998-04-15 Orion Yhtymo Oy New compounds and pharmaceutical compositions thereof
US20040186185A1 (en) * 1998-05-07 2004-09-23 Steiner Mitchell S. Method for treatment and chemoprevention of prostate cancer
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
SI1235776T1 (sl) * 1999-11-16 2006-06-30 Hormos Medical Corp Trifenilalkenski derivati in njihova uporaba kot selektivni estrogenski receptorski modulatorji
TW593256B (en) * 1999-11-16 2004-06-21 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
US6245819B1 (en) * 2000-07-21 2001-06-12 Hormos Medical Oy, Ltd. Method for the treatment of vaginal dryness and sexual dysfunction in women during or after the menopause
US6613083B2 (en) 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
US20060269611A1 (en) * 2001-11-29 2006-11-30 Steiner Mitchell S Prevention and treatment of androgen-deprivation induced osteoporosis
US20080249183A1 (en) * 2001-11-29 2008-10-09 Steiner Mitchell S Treatment of androgen-deprivation induced osteoporosis
US20040214898A1 (en) * 2001-11-29 2004-10-28 Steiner Mitchell S. Methods for treating hot flashes
US20050080143A1 (en) * 2001-11-29 2005-04-14 Steiner Mitchell S. Treatment of androgen-deprivation induced osteoporosis
US20040248989A1 (en) * 2003-06-05 2004-12-09 Risto Santti Method for the treatment or prevention of lower urinary tract symptoms
US8236861B2 (en) 2004-02-13 2012-08-07 Hormos Medical Corporation Method for enhancing the bioavailablity of ospemifene
US8642079B2 (en) * 2004-02-23 2014-02-04 Hormos Medical Corporation Solid formulations of ospemifene
US20050187302A1 (en) * 2004-02-23 2005-08-25 Hormos Medical Corporation Method for treatment or prevention of osteoporosis in individuals with high bone turnover
CN1950071A (zh) * 2004-05-04 2007-04-18 霍尔莫斯医疗有限公司 ospemifene的新口服制剂
US8758821B2 (en) 2004-05-04 2014-06-24 Hormos Medical Ltd. Oral formulations of ospemifene
US20060293294A1 (en) * 2004-09-03 2006-12-28 Hormos Medical Corporation Method for treatment or prevention of androgen deficiency
US20060270641A1 (en) * 2005-05-31 2006-11-30 Steiner Mitchell S Method for chemoprevention of prostate cancer
US8158828B2 (en) 2005-11-28 2012-04-17 Gtx, Inc. Nuclear receptor binding agents
US8546451B2 (en) 2005-11-28 2013-10-01 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US8637706B2 (en) 2005-11-28 2014-01-28 Gtx, Inc. Nuclear receptor binding agents
US9409856B2 (en) 2005-11-28 2016-08-09 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
CA2652783C (en) * 2006-05-22 2015-07-14 Hormos Medical Ltd. Selective estrogen receptor modulators or aromatase inhibitors for treating chronic nonbacterial prostatitis
US20080176255A1 (en) * 2007-01-23 2008-07-24 Edward Sobek Mold detection composition and methods
KR101510646B1 (ko) 2007-02-14 2015-04-10 호르모스 메디칼 리미티드 치료적으로 유용한 트리페닐부텐 유도체의 제조 방법
WO2008099060A2 (en) 2007-02-14 2008-08-21 Hormos Medical Ltd Methods for the preparation of fispemifene from ospemifene
WO2008157335A2 (en) 2007-06-13 2008-12-24 Quatrx Pharmaceuticals Company Methods for the treatment of erectile dysfunction using fispemifene
US9624161B2 (en) 2009-02-23 2017-04-18 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US9427418B2 (en) 2009-02-23 2016-08-30 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
KR101149529B1 (ko) 2009-09-11 2012-05-25 한국화학연구원 인덴온 유도체 및 이를 포함하는 약학적 조성물
SI2526080T1 (sl) 2010-01-19 2014-07-31 Cambrex Karlskoga Ab Novi postopki za izdelavo benzofenonskih derivatov
EP2909164A1 (en) 2012-10-19 2015-08-26 Fermion Oy A process for the preparation of ospemifene
JP2015532309A (ja) * 2012-10-19 2015-11-09 フェルミオン オサケ ユキチュア オスペミフェンの製造方法
CN103739456A (zh) * 2013-12-03 2014-04-23 镇江圣安医药有限公司 2-（对-（（z-4-氯-1,2-二苯基-1-丁烯基）苯氧基）乙醇的新型衍生物及其应用
US9975832B2 (en) * 2014-12-29 2018-05-22 Olon S.P.A. Process for the preparation of ospemifene and fispemifene
WO2016110805A1 (en) * 2015-01-09 2016-07-14 Glenmark Pharmaceuticals Limited Process for preparation of ospemifene
KR102055542B1 (ko) 2015-03-10 2019-12-13 시오노기 잉크 고체 분산체
KR102052133B1 (ko) * 2017-08-10 2019-12-05 고려대학교 산학협력단 당 부가된 오스페미펜, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물
GR1009542B (el) 2018-04-25 2019-06-07 Φαρματεν Α.Β.Ε.Ε. Καψουλα μαλακης γελης που περιλαμβανει εναν εκλεκτικο ρυθμιστη οιστρογονικων υποδοχεων
KR20220115062A (ko) 2021-02-09 2022-08-17 (주)오스티오뉴로젠 크로몬 구조의 화합물을 포함하는 골다공증의 예방 및 치료용 약학적 조성물

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9207437D0 (en) * 1992-04-03 1992-05-20 Orion Yhtymae Oy Topical administration of toremifene and its metabolites

Also Published As

Publication number Publication date
GB9418067D0 (en) 1994-10-26
JP3910211B2 (ja) 2007-04-25
NO971037D0 (no) 1997-03-06
EP0779808A1 (en) 1997-06-25
US5750576A (en) 1998-05-12
NZ291836A (en) 1998-06-26
ZA957481B (en) 1996-04-09
AU3347895A (en) 1996-03-27
DK0779808T3 (da) 2000-03-13
FI118755B (fi) 2008-03-14
IL115171A (en) 2001-08-26
NO971037L (no) 1997-04-29
CA2198389A1 (en) 1996-03-14
NO315785B1 (no) 2003-10-27
DE69511566T2 (de) 2000-04-27
CA2198389C (en) 2007-02-20
FI970920A0 (fi) 1997-03-04
WO1996007402A1 (en) 1996-03-14
AU699845B2 (en) 1998-12-17
IL115171A0 (en) 1995-12-31
JPH10505079A (ja) 1998-05-19
SI0779808T1 (en) 1999-10-31
DE69511566D1 (de) 1999-09-23
ATE183389T1 (de) 1999-09-15
GR3031109T3 (en) 1999-12-31
EP0779808B1 (en) 1999-08-18
FI970920L (fi) 1997-03-04
US5912273A (en) 1999-06-15

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