CA2197178C - Composes de type bicyclolactame; leur emploi et intermediaire pour leur preparation - Google Patents

Composes de type bicyclolactame; leur emploi et intermediaire pour leur preparation Download PDF

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Publication number
CA2197178C
CA2197178C CA002197178A CA2197178A CA2197178C CA 2197178 C CA2197178 C CA 2197178C CA 002197178 A CA002197178 A CA 002197178A CA 2197178 A CA2197178 A CA 2197178A CA 2197178 C CA2197178 C CA 2197178C
Authority
CA
Canada
Prior art keywords
group
compound
benzoyl
bicyclolactam
azabicyclo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002197178A
Other languages
English (en)
Other versions
CA2197178A1 (fr
Inventor
Kazuo Ogawa
Ichiro Yamawaki
Manabu Kaneda
Takashi Arima
Junji Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of CA2197178A1 publication Critical patent/CA2197178A1/fr
Application granted granted Critical
Publication of CA2197178C publication Critical patent/CA2197178C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Les composés de bicyclolactame représentés par la formule générale (1) sont utiles comme ingrédient actif de médicaments ayant un excellent effet anxiolytique et une sécurité élevée avec peu d'effets secondaires tels qu'un effet hypnotique, de relaxation musculaire, sédatif, etc. Dans cette formule, R représente oxo ou -OR<1> (R<1> représente hydrogène ou acyle); A représente l'un des groupes suivants (2) et (3); Q représente hydrogène ou un alkyle inférieur; l vaut 1 ou 2, m vaut 0 ou 1, et n vaut 0, 1 ou 2 mais m et n ne valent pas 0 en même temps; R<2> est du benzoyle éventuellement substitué.
CA002197178A 1995-06-12 1996-06-07 Composes de type bicyclolactame; leur emploi et intermediaire pour leur preparation Expired - Fee Related CA2197178C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP7/170329 1995-06-12
JP17032995 1995-06-12
JP27465495A JP3161948B2 (ja) 1995-06-12 1995-09-27 ビシクロラクタム化合物
JP7/274654 1995-09-27
PCT/JP1996/001565 WO1996041796A1 (fr) 1995-06-12 1996-06-07 Composes de bicyclolactame, leur emploi et compose intermediaire dans leur production

Publications (2)

Publication Number Publication Date
CA2197178A1 CA2197178A1 (fr) 1996-12-27
CA2197178C true CA2197178C (fr) 2001-05-01

Family

ID=26493354

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002197178A Expired - Fee Related CA2197178C (fr) 1995-06-12 1996-06-07 Composes de type bicyclolactame; leur emploi et intermediaire pour leur preparation

Country Status (10)

Country Link
JP (1) JP3161948B2 (fr)
KR (1) KR100220172B1 (fr)
AT (1) ATE224369T1 (fr)
AU (1) AU697656B2 (fr)
CA (1) CA2197178C (fr)
DE (1) DE69623747T2 (fr)
DK (1) DK0790237T3 (fr)
ES (1) ES2183956T3 (fr)
PT (1) PT790237E (fr)
WO (1) WO1996041796A1 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0466933B1 (fr) * 1990-02-02 1995-11-22 Taiho Pharmaceutical Company Limited Derive de bicyclolactame
PT713702E (pt) * 1994-03-28 2005-01-31 Taiho Pharmaceutical Co Ltd Agente ansiolitico

Also Published As

Publication number Publication date
ES2183956T3 (es) 2003-04-01
KR100220172B1 (ko) 1999-09-01
AU5911896A (en) 1997-01-09
JP3161948B2 (ja) 2001-04-25
WO1996041796A1 (fr) 1996-12-27
KR970704686A (ko) 1997-09-06
ATE224369T1 (de) 2002-10-15
CA2197178A1 (fr) 1996-12-27
DE69623747D1 (de) 2002-10-24
PT790237E (pt) 2003-02-28
JPH0959251A (ja) 1997-03-04
AU697656B2 (en) 1998-10-15
DE69623747T2 (de) 2003-05-22
DK0790237T3 (da) 2002-10-14

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