AU5911896A - Bicyclolactam compounds, use thereof and intermediates for preparing thereof - Google Patents
Bicyclolactam compounds, use thereof and intermediates for preparing thereofInfo
- Publication number
- AU5911896A AU5911896A AU59118/96A AU5911896A AU5911896A AU 5911896 A AU5911896 A AU 5911896A AU 59118/96 A AU59118/96 A AU 59118/96A AU 5911896 A AU5911896 A AU 5911896A AU 5911896 A AU5911896 A AU 5911896A
- Authority
- AU
- Australia
- Prior art keywords
- effect
- intermediates
- preparing
- bicyclolactam
- represents hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Bicyclolactam compounds represented by general formula (1) are useful as the active ingredient of medicines having an excellent anxiolytic effect and a high safety with little side effects such as a hypnotic effect, a muscle relaxing effect, a sedative effect, etc. In said formula, R represents oxo or -OR<1> (wherein R<1> represents hydrogen or acyl); A represents one of the following groups (2) and (3); Q represents hydrogen or lower alkyl; l is 1 or 2, m is 0 or 1; and n is 0, 1 or 2, provided that m and n are not 0 at the same time; R<2> represents optionally substituted benzoyl.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7-170329 | 1995-06-12 | ||
JP17032995 | 1995-06-12 | ||
JP7-274654 | 1995-09-27 | ||
JP27465495A JP3161948B2 (en) | 1995-06-12 | 1995-09-27 | Bicyclolactam compound |
PCT/JP1996/001565 WO1996041796A1 (en) | 1995-06-12 | 1996-06-07 | Bicyclolactam compounds, use of the same and intermediate in the production of the same |
Publications (2)
Publication Number | Publication Date |
---|---|
AU5911896A true AU5911896A (en) | 1997-01-09 |
AU697656B2 AU697656B2 (en) | 1998-10-15 |
Family
ID=26493354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU59118/96A Ceased AU697656B2 (en) | 1995-06-12 | 1996-06-07 | Bicyclolactam compounds, use thereof and intermediates for preparing thereof |
Country Status (10)
Country | Link |
---|---|
JP (1) | JP3161948B2 (en) |
KR (1) | KR100220172B1 (en) |
AT (1) | ATE224369T1 (en) |
AU (1) | AU697656B2 (en) |
CA (1) | CA2197178C (en) |
DE (1) | DE69623747T2 (en) |
DK (1) | DK0790237T3 (en) |
ES (1) | ES2183956T3 (en) |
PT (1) | PT790237E (en) |
WO (1) | WO1996041796A1 (en) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0466933B1 (en) * | 1990-02-02 | 1995-11-22 | Taiho Pharmaceutical Company Limited | Bicyclolactam derivative |
PT713702E (en) * | 1994-03-28 | 2005-01-31 | Taiho Pharmaceutical Co Ltd | ANSIOLITIC AGENT |
-
1995
- 1995-09-27 JP JP27465495A patent/JP3161948B2/en not_active Expired - Fee Related
-
1996
- 1996-06-07 CA CA002197178A patent/CA2197178C/en not_active Expired - Fee Related
- 1996-06-07 DK DK96916350T patent/DK0790237T3/en active
- 1996-06-07 ES ES96916350T patent/ES2183956T3/en not_active Expired - Lifetime
- 1996-06-07 PT PT96916350T patent/PT790237E/en unknown
- 1996-06-07 KR KR1019970700925A patent/KR100220172B1/en not_active IP Right Cessation
- 1996-06-07 AU AU59118/96A patent/AU697656B2/en not_active Ceased
- 1996-06-07 WO PCT/JP1996/001565 patent/WO1996041796A1/en active IP Right Grant
- 1996-06-07 DE DE69623747T patent/DE69623747T2/en not_active Expired - Fee Related
- 1996-06-07 AT AT96916350T patent/ATE224369T1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2183956T3 (en) | 2003-04-01 |
KR100220172B1 (en) | 1999-09-01 |
JP3161948B2 (en) | 2001-04-25 |
WO1996041796A1 (en) | 1996-12-27 |
CA2197178C (en) | 2001-05-01 |
KR970704686A (en) | 1997-09-06 |
ATE224369T1 (en) | 2002-10-15 |
CA2197178A1 (en) | 1996-12-27 |
DE69623747D1 (en) | 2002-10-24 |
PT790237E (en) | 2003-02-28 |
JPH0959251A (en) | 1997-03-04 |
AU697656B2 (en) | 1998-10-15 |
DE69623747T2 (en) | 2003-05-22 |
DK0790237T3 (en) | 2002-10-14 |
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