DK0790237T3 - Bicyclolactam compounds, their use and intermediates for their preparation - Google Patents

Bicyclolactam compounds, their use and intermediates for their preparation

Info

Publication number
DK0790237T3
DK0790237T3 DK96916350T DK96916350T DK0790237T3 DK 0790237 T3 DK0790237 T3 DK 0790237T3 DK 96916350 T DK96916350 T DK 96916350T DK 96916350 T DK96916350 T DK 96916350T DK 0790237 T3 DK0790237 T3 DK 0790237T3
Authority
DK
Denmark
Prior art keywords
effect
intermediates
preparation
bicyclolactam
represents hydrogen
Prior art date
Application number
DK96916350T
Other languages
Danish (da)
Inventor
Kazuo Ogawa
Ichiro Yamawaki
Manabu Kaneda
Takashi Arima
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DK0790237T3 publication Critical patent/DK0790237T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered

Abstract

Bicyclolactam compounds represented by general formula (1) are useful as the active ingredient of medicines having an excellent anxiolytic effect and a high safety with little side effects such as a hypnotic effect, a muscle relaxing effect, a sedative effect, etc. In said formula, R represents oxo or -OR<1> (wherein R<1> represents hydrogen or acyl); A represents one of the following groups (2) and (3); Q represents hydrogen or lower alkyl; l is 1 or 2, m is 0 or 1; and n is 0, 1 or 2, provided that m and n are not 0 at the same time; R<2> represents optionally substituted benzoyl.
DK96916350T 1995-06-12 1996-06-07 Bicyclolactam compounds, their use and intermediates for their preparation DK0790237T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP17032995 1995-06-12
JP27465495A JP3161948B2 (en) 1995-06-12 1995-09-27 Bicyclolactam compound
PCT/JP1996/001565 WO1996041796A1 (en) 1995-06-12 1996-06-07 Bicyclolactam compounds, use of the same and intermediate in the production of the same

Publications (1)

Publication Number Publication Date
DK0790237T3 true DK0790237T3 (en) 2002-10-14

Family

ID=26493354

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96916350T DK0790237T3 (en) 1995-06-12 1996-06-07 Bicyclolactam compounds, their use and intermediates for their preparation

Country Status (10)

Country Link
JP (1) JP3161948B2 (en)
KR (1) KR100220172B1 (en)
AT (1) ATE224369T1 (en)
AU (1) AU697656B2 (en)
CA (1) CA2197178C (en)
DE (1) DE69623747T2 (en)
DK (1) DK0790237T3 (en)
ES (1) ES2183956T3 (en)
PT (1) PT790237E (en)
WO (1) WO1996041796A1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0466933B1 (en) * 1990-02-02 1995-11-22 Taiho Pharmaceutical Company Limited Bicyclolactam derivative
KR0168508B1 (en) * 1994-03-28 1999-01-15 고바야시 유키오 Anxiolytic agent

Also Published As

Publication number Publication date
AU697656B2 (en) 1998-10-15
CA2197178C (en) 2001-05-01
KR100220172B1 (en) 1999-09-01
DE69623747D1 (en) 2002-10-24
ES2183956T3 (en) 2003-04-01
WO1996041796A1 (en) 1996-12-27
AU5911896A (en) 1997-01-09
CA2197178A1 (en) 1996-12-27
JPH0959251A (en) 1997-03-04
KR970704686A (en) 1997-09-06
DE69623747T2 (en) 2003-05-22
ATE224369T1 (en) 2002-10-15
PT790237E (en) 2003-02-28
JP3161948B2 (en) 2001-04-25

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