DE69623747D1 - BICYCLOLACTAM COMPOUNDS THEIR USE AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION - Google Patents

BICYCLOLACTAM COMPOUNDS THEIR USE AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION

Info

Publication number
DE69623747D1
DE69623747D1 DE69623747T DE69623747T DE69623747D1 DE 69623747 D1 DE69623747 D1 DE 69623747D1 DE 69623747 T DE69623747 T DE 69623747T DE 69623747 T DE69623747 T DE 69623747T DE 69623747 D1 DE69623747 D1 DE 69623747D1
Authority
DE
Germany
Prior art keywords
effect
production
intermediate products
bicyclolactam
bicyclolactam compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69623747T
Other languages
German (de)
Other versions
DE69623747T2 (en
Inventor
Kazuo Ogawa
Ichiro Yamawaki
Manabu Kaneda
Takashi Arima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of DE69623747D1 publication Critical patent/DE69623747D1/en
Application granted granted Critical
Publication of DE69623747T2 publication Critical patent/DE69623747T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Bicyclolactam compounds represented by general formula (1) are useful as the active ingredient of medicines having an excellent anxiolytic effect and a high safety with little side effects such as a hypnotic effect, a muscle relaxing effect, a sedative effect, etc. In said formula, R represents oxo or -OR<1> (wherein R<1> represents hydrogen or acyl); A represents one of the following groups (2) and (3); Q represents hydrogen or lower alkyl; l is 1 or 2, m is 0 or 1; and n is 0, 1 or 2, provided that m and n are not 0 at the same time; R<2> represents optionally substituted benzoyl.
DE69623747T 1995-06-12 1996-06-07 BICYCLOLACTAM COMPOUNDS THEIR USE AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION Expired - Fee Related DE69623747T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP17032995 1995-06-12
JP27465495A JP3161948B2 (en) 1995-06-12 1995-09-27 Bicyclolactam compound
PCT/JP1996/001565 WO1996041796A1 (en) 1995-06-12 1996-06-07 Bicyclolactam compounds, use of the same and intermediate in the production of the same

Publications (2)

Publication Number Publication Date
DE69623747D1 true DE69623747D1 (en) 2002-10-24
DE69623747T2 DE69623747T2 (en) 2003-05-22

Family

ID=26493354

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69623747T Expired - Fee Related DE69623747T2 (en) 1995-06-12 1996-06-07 BICYCLOLACTAM COMPOUNDS THEIR USE AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION

Country Status (10)

Country Link
JP (1) JP3161948B2 (en)
KR (1) KR100220172B1 (en)
AT (1) ATE224369T1 (en)
AU (1) AU697656B2 (en)
CA (1) CA2197178C (en)
DE (1) DE69623747T2 (en)
DK (1) DK0790237T3 (en)
ES (1) ES2183956T3 (en)
PT (1) PT790237E (en)
WO (1) WO1996041796A1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0466933B1 (en) * 1990-02-02 1995-11-22 Taiho Pharmaceutical Company Limited Bicyclolactam derivative
PT713702E (en) * 1994-03-28 2005-01-31 Taiho Pharmaceutical Co Ltd ANSIOLITIC AGENT

Also Published As

Publication number Publication date
ES2183956T3 (en) 2003-04-01
KR100220172B1 (en) 1999-09-01
AU5911896A (en) 1997-01-09
JP3161948B2 (en) 2001-04-25
WO1996041796A1 (en) 1996-12-27
CA2197178C (en) 2001-05-01
KR970704686A (en) 1997-09-06
ATE224369T1 (en) 2002-10-15
CA2197178A1 (en) 1996-12-27
PT790237E (en) 2003-02-28
JPH0959251A (en) 1997-03-04
AU697656B2 (en) 1998-10-15
DE69623747T2 (en) 2003-05-22
DK0790237T3 (en) 2002-10-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee