CA2187336A1 - Formulations pharmaceutiques utilisees dans le traitement de la pollinose du cedre du japon - Google Patents
Formulations pharmaceutiques utilisees dans le traitement de la pollinose du cedre du japonInfo
- Publication number
- CA2187336A1 CA2187336A1 CA002187336A CA2187336A CA2187336A1 CA 2187336 A1 CA2187336 A1 CA 2187336A1 CA 002187336 A CA002187336 A CA 002187336A CA 2187336 A CA2187336 A CA 2187336A CA 2187336 A1 CA2187336 A1 CA 2187336A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- cji
- peptide
- peptides
- gly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- UKEVLVBHRKWECS-LSJOCFKGSA-N Val-Ile-Gly Chemical compound CC[C@H](C)[C@@H](C(=O)NCC(=O)O)NC(=O)[C@H](C(C)C)N UKEVLVBHRKWECS-LSJOCFKGSA-N 0.000 description 1
- AIWLHFZYOUUJGB-UFYCRDLUSA-N Val-Phe-Tyr Chemical compound C([C@H](NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)C1=CC=CC=C1 AIWLHFZYOUUJGB-UFYCRDLUSA-N 0.000 description 1
- KSFXWENSJABBFI-ZKWXMUAHSA-N Val-Ser-Asn Chemical compound [H]N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(O)=O KSFXWENSJABBFI-ZKWXMUAHSA-N 0.000 description 1
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- LCHZBEUVGAVMKS-RHYQMDGZSA-N Val-Thr-Leu Chemical compound CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(O)=O LCHZBEUVGAVMKS-RHYQMDGZSA-N 0.000 description 1
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- GTACFKZDQFTVAI-STECZYCISA-N Val-Tyr-Ile Chemical compound CC[C@H](C)[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)CC1=CC=C(O)C=C1 GTACFKZDQFTVAI-STECZYCISA-N 0.000 description 1
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- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
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- KOSRFJWDECSPRO-UHFFFAOYSA-N alpha-L-glutamyl-L-glutamic acid Natural products OC(=O)CCC(N)C(=O)NC(CCC(O)=O)C(O)=O KOSRFJWDECSPRO-UHFFFAOYSA-N 0.000 description 1
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
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- 239000013024 dilution buffer Substances 0.000 description 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 230000002222 downregulating effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000003979 eosinophil Anatomy 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 108010055341 glutamyl-glutamic acid Proteins 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
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- 230000001939 inductive effect Effects 0.000 description 1
- 239000003701 inert diluent Substances 0.000 description 1
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- 230000005764 inhibitory process Effects 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 229960002068 insulin lispro Drugs 0.000 description 1
- 230000017307 interleukin-4 production Effects 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 108010044056 leucyl-phenylalanine Proteins 0.000 description 1
- 108010012058 leucyltyrosine Proteins 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 241001515942 marmosets Species 0.000 description 1
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- 229940045641 monobasic sodium phosphate Drugs 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
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- 230000037452 priming Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 108010029020 prolylglycine Proteins 0.000 description 1
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- 239000002510 pyrogen Substances 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000012465 retentate Substances 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 108010026333 seryl-proline Proteins 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
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- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Botany (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
La présente invention se rapporte à de nouveaux peptides de Cry j I qui ont été modifiés dans le cadre d'un système de préformulation afin de développer un médicament optimisé destiné au traitement des personnes souffrant d'allergie due à l'allergène du pollen du cèdre du Japon ou à un allergène qui présente une réaction croisée immunologique avec l'allergène du cèdre du Japon. Ces peptides modifiés possèdent certaines caractéristiques uniques qui les rendent particulièrement aptes à être utilisées dans la formulation de médicaments. La présente invention se rapporte également à des compositions thérapeutiques et à des formulations multipeptidiques qui ont été optimisées pour adapter et conserver des caractéristiques uniques des peptides modifiés Cry j I, et en même temps, afin d'obtenir un effet thérapeutique maximum lorsqu'ils sont utilisés dans des régimes thérapeutiques s'appliquant au traitement de la pollinose du cèdre du Japon chez l'homme.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22624894A | 1994-04-08 | 1994-04-08 | |
| US35022594A | 1994-12-06 | 1994-12-06 | |
| US08/350,225 | 1994-12-06 | ||
| US08/226,248 | 1994-12-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2187336A1 true CA2187336A1 (fr) | 1995-10-19 |
Family
ID=26920341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002187336A Abandoned CA2187336A1 (fr) | 1994-04-08 | 1995-04-06 | Formulations pharmaceutiques utilisees dans le traitement de la pollinose du cedre du japon |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0756629A1 (fr) |
| JP (1) | JP4179422B2 (fr) |
| AU (1) | AU2241995A (fr) |
| CA (1) | CA2187336A1 (fr) |
| WO (1) | WO1995027786A1 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5773003A (en) * | 1995-03-31 | 1998-06-30 | Immulogic, Inc. | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same |
| DE69637089T2 (de) * | 1995-03-31 | 2008-01-17 | Xenova Research Ltd., Slough | Hapten-Träger-Konjugate zur Anwendung in der Drogen-Missbrauchs-Therapie |
| JP3734040B2 (ja) * | 1996-06-14 | 2006-01-11 | 明治乳業株式会社 | Ｔ細胞エピトープペプチド |
| JP4176750B2 (ja) * | 1996-06-14 | 2008-11-05 | 明治乳業株式会社 | Ｔ細胞エピトープペプチド |
| SE9603468D0 (sv) * | 1996-09-23 | 1996-09-23 | Astra Ab | New compounds |
| SE9603463D0 (sv) * | 1996-09-23 | 1996-09-23 | Astra Ab | New compounds |
| US7025964B1 (en) * | 1996-11-13 | 2006-04-11 | Meiji Dairies Corporation | Peptide-based immunotherapeutic agent |
| JP3939401B2 (ja) * | 1997-09-17 | 2007-07-04 | 三共株式会社 | ペプチド及びその用途 |
| US6232082B1 (en) | 1998-12-01 | 2001-05-15 | Nabi | Hapten-carrier conjugates for treating and preventing nicotine addiction |
| WO2005027774A2 (fr) * | 2003-09-17 | 2005-03-31 | Baby Boost, Inc. | Procede et appareil de prevention d'allergies |
| JP3987562B2 (ja) * | 2006-10-23 | 2007-10-10 | 第一三共株式会社 | ペプチド及びその用途 |
| JP3987563B2 (ja) * | 2006-10-23 | 2007-10-10 | 第一三共株式会社 | ペプチド及びその用途 |
| JP2012240978A (ja) * | 2011-05-20 | 2012-12-10 | Nitto Denko Corp | 医薬組成物及びゼリー状製剤 |
| US20120294894A1 (en) * | 2011-05-20 | 2012-11-22 | Nitto Denko Corporation | Pharmaceutical composition and method for producing the same |
| JP2012240975A (ja) * | 2011-05-20 | 2012-12-10 | Nitto Denko Corp | 医薬組成物及びゼリー状製剤 |
| JP6200630B2 (ja) * | 2012-02-10 | 2017-09-20 | オーストリッチファーマ株式会社 | 医薬組成物 |
| WO2016209959A2 (fr) | 2015-06-22 | 2016-12-29 | Alk-Abelló A/S | Combinaisons de peptides et leur utilisation dans le traitement de l'allergie aux pollen de cèdre |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994001560A1 (fr) * | 1991-07-12 | 1994-01-20 | Immulogic Pharmaceutical Corporation | Proteines et peptides allergenes tires du pollen du cedre du japon |
-
1995
- 1995-04-06 EP EP95915576A patent/EP0756629A1/fr not_active Withdrawn
- 1995-04-06 CA CA002187336A patent/CA2187336A1/fr not_active Abandoned
- 1995-04-06 WO PCT/US1995/004249 patent/WO1995027786A1/fr not_active Application Discontinuation
- 1995-04-06 JP JP52644095A patent/JP4179422B2/ja not_active Expired - Lifetime
- 1995-04-06 AU AU22419/95A patent/AU2241995A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2241995A (en) | 1995-10-30 |
| JP4179422B2 (ja) | 2008-11-12 |
| EP0756629A1 (fr) | 1997-02-05 |
| WO1995027786A1 (fr) | 1995-10-19 |
| JPH09511747A (ja) | 1997-11-25 |
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