CA2185448A1 - Utilisation d'inhibiteurs de la lipoxygenase en tant qu'agents therapeutiques et d'intervention anticancereux - Google Patents
Utilisation d'inhibiteurs de la lipoxygenase en tant qu'agents therapeutiques et d'intervention anticancereuxInfo
- Publication number
- CA2185448A1 CA2185448A1 CA002185448A CA2185448A CA2185448A1 CA 2185448 A1 CA2185448 A1 CA 2185448A1 CA 002185448 A CA002185448 A CA 002185448A CA 2185448 A CA2185448 A CA 2185448A CA 2185448 A1 CA2185448 A1 CA 2185448A1
- Authority
- CA
- Canada
- Prior art keywords
- derivative
- epithelial cell
- cancer
- subject
- lipoxygenase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne une méthode de traitement d'un cancer dérivé des cellules épithéliales chez un sujet nécessitant ce type de traitement. Ladite méthode consiste à administrer au sujet un inhibiteur de la 5-lipoxygénase ou un dérivé de ce dernier en une dose efficace pour traiter un cancer dérivé des cellules épithéliales. L'invention se rapporte également à une méthode de prévention d'un cancer dérivé des cellules épithéliales chez un sujet nécessitant ce type de prévention, laquelle consiste à administrer à ce dernier un inhibiteur de la 5-lipoxygénase en une dose efficace pour prévenir le cancer dérivé des cellules épithéliales. Les inhibiteurs de la 5-lipoxygénase appropriés utiles dans les méthodes selon l'invention sont constitués, de préférence, de 2-(12(hydroxydodéca-5,10-dinyl)-3,5,6-triméthyl-1,4-benzoquinone et de dérivés de celui-ci; d'acide nordihydroguaïarétique et de dérivés de celui-ci; et d'acide 3-[1-(4-chlorobenzyl)-3-t-butyl-thio-t-isopropyl-indol-2-yl]-2-2-diméthylpropanoïque et de dérivés de celui-ci. L'invention porte également sur des dérivés d'hydroxy-urée faisant office d'inhibiteurs de la 5-lipoxygénase destinés à être utilisés dans la prévention et le traitement de cancers dérivés des cellules épithéliales.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21207494A | 1994-03-14 | 1994-03-14 | |
US08/212,074 | 1994-03-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2185448A1 true CA2185448A1 (fr) | 1995-09-21 |
Family
ID=22789451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002185448A Abandoned CA2185448A1 (fr) | 1994-03-14 | 1995-03-14 | Utilisation d'inhibiteurs de la lipoxygenase en tant qu'agents therapeutiques et d'intervention anticancereux |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0750496A1 (fr) |
AU (1) | AU698313B2 (fr) |
CA (1) | CA2185448A1 (fr) |
WO (1) | WO1995024894A2 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19624659A1 (de) | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalken- und Pyridylalkinsäureamide |
US6451816B1 (en) | 1997-06-20 | 2002-09-17 | Klinge Pharma Gmbh | Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression |
DE19624704A1 (de) | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalkansäureamide |
DE19756236A1 (de) * | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue piperazinylsubstituierte Pyridylalkan-, alken- und -alkincarbonsäureamide |
DE19756261A1 (de) * | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide |
DE19756212A1 (de) | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide |
US6903118B1 (en) | 1997-12-17 | 2005-06-07 | Klinge Pharma Gmbh | Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides |
DE19756235A1 (de) | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide |
EP1031564A1 (fr) | 1999-02-26 | 2000-08-30 | Klinge Pharma GmbH | Inhibiteurs de la formation du nicotinamide mononucléotide et leur utilisation dans le traitement du cancer |
US6756399B2 (en) | 2001-06-29 | 2004-06-29 | The United States Of America As Represented By The Department Of Health And Human Services | Use of lipoxygenase inhibitors and PPAR ligands as anti-cancer therapeutic and intervention agents |
GB0410103D0 (en) * | 2004-05-06 | 2004-06-09 | Biolipox Ab | New method |
WO2010124283A2 (fr) | 2009-04-24 | 2010-10-28 | The Jackson Laboratory | Procédés et compositions liées à des tumeurs malignes hématologiques |
JP6393684B2 (ja) | 2012-09-07 | 2018-09-19 | バイオエレクトロン テクノロジー コーポレイション | 個体のレドックス状態の調節において使用するためのキノン誘導体 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5008294A (en) * | 1985-02-11 | 1991-04-16 | Chemex Pharmaceuticals, Inc. | Methods of treating tumors with compositions of catecholic butanes |
US4554276A (en) * | 1983-10-03 | 1985-11-19 | Pfizer Inc. | 2-Amino-5-hydroxy-4-methylpyrimidine derivatives |
US4880637A (en) * | 1985-02-11 | 1989-11-14 | Chemex Pharmaceuticals, Inc. | Compositions of catecholic butanes with zinc |
GB8619433D0 (en) * | 1986-08-08 | 1986-09-17 | Lilly Industries Ltd | Pharmaceutical compounds |
EP0290442A4 (fr) * | 1986-11-19 | 1990-07-03 | Chemex Pharmaceuticals Inc | Composes pharmacologiquement actifs et leurs melanges, compositions organiques et sels metalliques. |
CA1321349C (fr) * | 1986-11-21 | 1993-08-17 | Robert Zimmerman | Association therapeutique d'un piegeur de radicaux libres ou d'un inhibiteur metabolique et d'une proteine bioactive |
GB9012252D0 (en) * | 1990-06-01 | 1990-07-18 | Lilly Industries Ltd | Pharmaceutical compounds |
GB9025514D0 (en) * | 1990-11-23 | 1991-01-09 | Wellcome Found | Anti-inflammatory compounds |
US5409690A (en) * | 1993-06-23 | 1995-04-25 | Chemex Pharmaceuticals, Inc. | Treatment of multidrug resistant diseases in cancer cell by potentiating with masoprocol |
-
1995
- 1995-03-14 AU AU22722/95A patent/AU698313B2/en not_active Ceased
- 1995-03-14 WO PCT/US1995/003337 patent/WO1995024894A2/fr not_active Application Discontinuation
- 1995-03-14 CA CA002185448A patent/CA2185448A1/fr not_active Abandoned
- 1995-03-14 EP EP95916100A patent/EP0750496A1/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
WO1995024894A3 (fr) | 1995-12-21 |
AU2272295A (en) | 1995-10-03 |
AU698313B2 (en) | 1998-10-29 |
WO1995024894A2 (fr) | 1995-09-21 |
EP0750496A1 (fr) | 1997-01-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Dead |