CA2177977A1 - Complexes metalliques substitues par halogenure d'aryle, substances pharmaceutiques contenant lesdits complexes, leur utilisation a des fins de diagnostic, et procedes de preparation desdists complexes et desdites substances pharmaceutiques - Google Patents
Complexes metalliques substitues par halogenure d'aryle, substances pharmaceutiques contenant lesdits complexes, leur utilisation a des fins de diagnostic, et procedes de preparation desdists complexes et desdites substances pharmaceutiquesInfo
- Publication number
- CA2177977A1 CA2177977A1 CA002177977A CA2177977A CA2177977A1 CA 2177977 A1 CA2177977 A1 CA 2177977A1 CA 002177977 A CA002177977 A CA 002177977A CA 2177977 A CA2177977 A CA 2177977A CA 2177977 A1 CA2177977 A1 CA 2177977A1
- Authority
- CA
- Canada
- Prior art keywords
- radical
- mmol
- acid
- stands
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
L'invention concerne de nouveaux complexes métalliques qui contiennent un ion d'un élément des nombres atomiques 12, 13, 20-31, 39-42, 44-50 ou 57-83 et un ligand complexant halogéné de formule (I), dans laquelle R?1¿, R?2¿, R?3¿, Z?1¿, Z?2¿, Z?3¿, U?1¿, U?2¿, V?1¿, V?2¿ ou V?3¿ ont différentes notations. L'invention concerne des substances pharmaceutiques contenant lesdits complexes, leur utilisation dans la résonance magnétique nucléaire et/ou dans le radiodiagnostic, notamment dans celui du foie, ainsi que des procédés de préparation desdits complexes et desdites substances pharmaceutiques.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP4341724.8 | 1993-12-03 | ||
DE4341724A DE4341724A1 (de) | 1993-12-03 | 1993-12-03 | Halogenaryl-substituierte Metallkomplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2177977A1 true CA2177977A1 (fr) | 1995-06-08 |
Family
ID=6504402
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002177977A Abandoned CA2177977A1 (fr) | 1993-12-03 | 1994-11-26 | Complexes metalliques substitues par halogenure d'aryle, substances pharmaceutiques contenant lesdits complexes, leur utilisation a des fins de diagnostic, et procedes de preparation desdists complexes et desdites substances pharmaceutiques |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0731784A1 (fr) |
JP (1) | JPH09506347A (fr) |
KR (1) | KR960706467A (fr) |
CN (1) | CN1136805A (fr) |
AU (1) | AU687477B2 (fr) |
CA (1) | CA2177977A1 (fr) |
DE (1) | DE4341724A1 (fr) |
HU (1) | HUT74389A (fr) |
IL (1) | IL111817A (fr) |
NO (1) | NO962243L (fr) |
NZ (1) | NZ276413A (fr) |
WO (1) | WO1995015306A1 (fr) |
ZA (1) | ZA949604B (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6458337B1 (en) | 1996-08-02 | 2002-10-01 | Dibra S.P.A | Diagnostic imaging contrast agent with improved in serum relaxivity |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW319763B (fr) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
BR9708470A (pt) | 1996-04-01 | 1999-04-13 | Epix Medical Inc | Agentes de contraste bioativados para formação de imagem para diagnósticos |
IT1283651B1 (it) * | 1996-08-02 | 1998-04-23 | Bracco Spa | Chelati paramagnetici ad alta relassivita' in siero |
DE19641197C2 (de) * | 1996-09-24 | 1999-02-18 | Schering Ag | Ionenpaare und ihre Verwendung als Kontrastmittel |
DE19740403C2 (de) * | 1997-09-09 | 1999-11-11 | Schering Ag | Neue Kontrastmittel |
FI20055653A (fi) | 2005-12-08 | 2007-06-09 | Wallac Oy | Leimausreagenssi |
KR100749087B1 (ko) * | 2006-06-02 | 2007-08-14 | 경북대학교 산학협력단 | 신규한 dtpa-비스-아미드 리간드들 및 이들이 결합된가돌리늄 착물 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3922005A1 (de) * | 1989-06-30 | 1991-01-10 | Schering Ag | Derivatisierte dtpa-komplexe, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
US5324503A (en) * | 1992-02-06 | 1994-06-28 | Mallinckrodt Medical, Inc. | Iodo-phenylated chelates for x-ray contrast |
-
1993
- 1993-12-03 DE DE4341724A patent/DE4341724A1/de not_active Withdrawn
-
1994
- 1994-11-26 WO PCT/EP1994/003919 patent/WO1995015306A1/fr not_active Application Discontinuation
- 1994-11-26 EP EP95901440A patent/EP0731784A1/fr not_active Withdrawn
- 1994-11-26 NZ NZ276413A patent/NZ276413A/en unknown
- 1994-11-26 CA CA002177977A patent/CA2177977A1/fr not_active Abandoned
- 1994-11-26 KR KR1019960702895A patent/KR960706467A/ko not_active Application Discontinuation
- 1994-11-26 AU AU10675/95A patent/AU687477B2/en not_active Ceased
- 1994-11-26 CN CN94194372A patent/CN1136805A/zh active Pending
- 1994-11-26 JP JP7515384A patent/JPH09506347A/ja active Pending
- 1994-11-26 HU HU9601478A patent/HUT74389A/hu unknown
- 1994-11-29 IL IL11181794A patent/IL111817A/en not_active IP Right Cessation
- 1994-12-02 ZA ZA949604A patent/ZA949604B/xx unknown
-
1996
- 1996-05-31 NO NO962243A patent/NO962243L/no unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6458337B1 (en) | 1996-08-02 | 2002-10-01 | Dibra S.P.A | Diagnostic imaging contrast agent with improved in serum relaxivity |
Also Published As
Publication number | Publication date |
---|---|
WO1995015306A1 (fr) | 1995-06-08 |
ZA949604B (en) | 1995-08-15 |
KR960706467A (ko) | 1996-12-09 |
JPH09506347A (ja) | 1997-06-24 |
IL111817A (en) | 1998-12-27 |
IL111817A0 (en) | 1995-01-24 |
DE4341724A1 (de) | 1995-06-08 |
NO962243L (no) | 1996-08-01 |
HUT74389A (en) | 1996-12-30 |
AU1067595A (en) | 1995-06-19 |
CN1136805A (zh) | 1996-11-27 |
NZ276413A (en) | 1998-04-27 |
NO962243D0 (no) | 1996-05-31 |
HU9601478D0 (en) | 1996-07-29 |
AU687477B2 (en) | 1998-02-26 |
EP0731784A1 (fr) | 1996-09-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |