CA2173751A1 - Nucleases de staphylocoque recombinantes et leur utilisation pour limiter la duree de survie de micro-orgasnismes produits par genie genetique - Google Patents
Nucleases de staphylocoque recombinantes et leur utilisation pour limiter la duree de survie de micro-orgasnismes produits par genie genetiqueInfo
- Publication number
- CA2173751A1 CA2173751A1 CA 2173751 CA2173751A CA2173751A1 CA 2173751 A1 CA2173751 A1 CA 2173751A1 CA 2173751 CA2173751 CA 2173751 CA 2173751 A CA2173751 A CA 2173751A CA 2173751 A1 CA2173751 A1 CA 2173751A1
- Authority
- CA
- Canada
- Prior art keywords
- gene
- cell
- sequence
- replicon
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
- C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Il est possible de limiter la durée de survie de cellules par l'introduction, dans ces cellules, d'un gène dont l'expression, qui peut être régulée, entraîne la formation d'une nucléase de Staphylococcus aureus tronquée et/ou mutée, à activité cytoplasmatique. Les populations de cellules contenant, outre un tel gène dont l'expression peut être régulée, un ADN codant un produit génique à activité immunologique, pesticide ou à dégradation de polluants environnementaux, sont aptes à être utilisées dans des compositions à activité immunologique, des compositions à activité pesticide et des compositions servant à dégrader des polluants environnementaux.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13566593A | 1993-10-13 | 1993-10-13 | |
| US08/135,665 | 1993-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2173751A1 true CA2173751A1 (fr) | 1995-04-20 |
Family
ID=22469101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2173751 Abandoned CA2173751A1 (fr) | 1993-10-13 | 1994-10-12 | Nucleases de staphylocoque recombinantes et leur utilisation pour limiter la duree de survie de micro-orgasnismes produits par genie genetique |
Country Status (5)
| Country | Link |
|---|---|
| AU (1) | AU7853094A (fr) |
| BR (1) | BR9407813A (fr) |
| CA (1) | CA2173751A1 (fr) |
| NZ (1) | NZ274482A (fr) |
| WO (1) | WO1995010614A1 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA00009561A (es) | 1998-03-30 | 2002-08-06 | Metabolix Inc | Cepas microbianas y procesos para la fabricacion de biomateriales. |
| DK1075512T3 (da) | 1998-05-07 | 2010-06-07 | Univ Bruxelles | Cytotoxinbaseret biologisk indkapsling |
| US7780961B2 (en) | 2001-05-03 | 2010-08-24 | Actogenix N.V. | Self-containing Lactococcus strain |
| ATE462779T1 (de) * | 2001-07-11 | 2010-04-15 | Lubitz Werner Prof Dr | Nukleinsäurefreie ghost zusammensetzungen |
| US6946267B2 (en) | 2002-03-13 | 2005-09-20 | Dr. Chip Biotechnology Inc. | Method for detecting Staphylococcus aureus |
| AU2003250250B2 (en) | 2002-06-19 | 2008-02-14 | Intrexon Actobiotics Nv | Methods and means to promote gut absorption |
| US8748126B2 (en) | 2005-11-29 | 2014-06-10 | Actogenix N.V. | Induction of mucosal tolerance to antigens |
| BRPI0807857A2 (pt) | 2007-01-25 | 2014-05-27 | Actogenix Nv | Tratamento de doença imune por meio de distribuição através da mucosa de antígenos. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE107697T1 (de) * | 1986-03-26 | 1994-07-15 | Genexpress Aps | Biologische eindämmung. |
| WO1988009821A1 (fr) * | 1987-06-12 | 1988-12-15 | Massachusetts Institute Of Technology | Systeme d'expression et de secretion coryneforme |
| ATE162220T1 (de) * | 1992-04-06 | 1998-01-15 | Gx Biosystems As | Eine methode zur einschränkung des uberlebens gentechnologisch hergestellter mikroorganismen in ihrer umgebung |
-
1994
- 1994-10-12 BR BR9407813A patent/BR9407813A/pt not_active Application Discontinuation
- 1994-10-12 WO PCT/DK1994/000381 patent/WO1995010614A1/fr active Application Filing
- 1994-10-12 CA CA 2173751 patent/CA2173751A1/fr not_active Abandoned
- 1994-10-12 AU AU78530/94A patent/AU7853094A/en not_active Abandoned
- 1994-10-12 NZ NZ27448294A patent/NZ274482A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995010614A1 (fr) | 1995-04-20 |
| AU7853094A (en) | 1995-05-04 |
| BR9407813A (pt) | 1997-05-06 |
| NZ274482A (en) | 1997-09-22 |
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