CA2158040A1 - Mucoadhesifs polymeriques pour l'administration d'agents immunogenes a la surface des muqueuses - Google Patents

Mucoadhesifs polymeriques pour l'administration d'agents immunogenes a la surface des muqueuses

Info

Publication number
CA2158040A1
CA2158040A1 CA002158040A CA2158040A CA2158040A1 CA 2158040 A1 CA2158040 A1 CA 2158040A1 CA 002158040 A CA002158040 A CA 002158040A CA 2158040 A CA2158040 A CA 2158040A CA 2158040 A1 CA2158040 A1 CA 2158040A1
Authority
CA
Canada
Prior art keywords
antigen
mucoadhesive
composition
virus
animal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002158040A
Other languages
English (en)
Inventor
Jacqueline D. Duncan
Dennis P. Schafer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SECRETECH Inc
Original Assignee
Jacqueline D. Duncan
Dennis P. Schafer
Secretech Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jacqueline D. Duncan, Dennis P. Schafer, Secretech Inc. filed Critical Jacqueline D. Duncan
Publication of CA2158040A1 publication Critical patent/CA2158040A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/5555—Muramyl dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • A61K2039/55594—Adjuvants of undefined constitution from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Inorganic Chemistry (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA002158040A 1993-03-11 1994-03-11 Mucoadhesifs polymeriques pour l'administration d'agents immunogenes a la surface des muqueuses Abandoned CA2158040A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2966893A 1993-03-11 1993-03-11
US08/029,668 1993-03-11
US11957893A 1993-09-13 1993-09-13
US08/119,578 1993-09-13

Publications (1)

Publication Number Publication Date
CA2158040A1 true CA2158040A1 (fr) 1994-09-15

Family

ID=26705210

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002158040A Abandoned CA2158040A1 (fr) 1993-03-11 1994-03-11 Mucoadhesifs polymeriques pour l'administration d'agents immunogenes a la surface des muqueuses

Country Status (7)

Country Link
EP (1) EP0688205A1 (fr)
JP (1) JPH08508247A (fr)
CN (1) CN1120310A (fr)
AU (1) AU692440B2 (fr)
BR (1) BR9405996A (fr)
CA (1) CA2158040A1 (fr)
WO (1) WO1994020070A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4033497B2 (ja) * 1996-09-06 2008-01-16 三菱化学株式会社 ワクチン製剤
GB9722682D0 (en) * 1997-10-27 1997-12-24 Scherer Ltd R P Pharmaceutical products
FR2775601B1 (fr) 1998-03-03 2001-09-21 Merial Sas Vaccins vivants recombines et adjuves
DE69942774D1 (de) * 1999-02-26 2010-10-28 Novartis Vaccines & Diagnostic Verwendung von bioadhaesiven und adjuvantien für die mukosale anwendung von antigenen
CA2366908A1 (fr) * 1999-03-24 2000-09-28 The Secretary Of State For Defence Composition vaccinale
GB0000891D0 (en) * 2000-01-14 2000-03-08 Allergy Therapeutics Ltd Formulation
JP2002154989A (ja) * 2000-11-14 2002-05-28 Lion Corp 眼科用組成物、及び生体粘膜への薬物の滞留性向上組成物
WO2002072012A2 (fr) * 2001-03-09 2002-09-19 Id Biomedical Corporation Of Quebec Nouvel adjuvant de vaccin proteosome-liposaccharide
AU2002252378B2 (en) * 2001-03-19 2007-10-18 Intercell Usa, Inc. Transcutaneous immunostimulation
DE10125731A1 (de) * 2001-05-17 2003-03-06 A I D Autoimmun Diagnostika Gm Darreichungsform von immunologischen Wirkstoffen
EP1420818B1 (fr) * 2001-07-26 2018-11-21 Otago Innovation Limited Compositions antigeniques
US8012505B2 (en) 2003-02-28 2011-09-06 Alk-Abello A/S Dosage form having a saccharide matrix
EP1599185A1 (fr) * 2003-02-28 2005-11-30 Alk-Abello A/S Forme de dosage presentant une matrice en saccharide
JP2009209086A (ja) * 2008-03-04 2009-09-17 Masami Moriyama 粘膜投与型ワクチン
KR20180049197A (ko) * 2008-09-17 2018-05-10 헌터 이뮤놀로지 리미티드 비피막형 헤모필루스 인플루엔자 백신 및 그의 용도
JP5762307B2 (ja) 2009-03-31 2015-08-12 国立感染症研究所長 経鼻投与用ワクチンを用いるインフルエンザの予防方法
JP2011057605A (ja) * 2009-09-09 2011-03-24 Masami Moriyama 粘膜投与型ワクチン
CN102665422B (zh) * 2009-12-23 2015-01-28 疫苗基因集团 通过口服施用重组乳酸乳球菌微型胶囊的免疫保护方法
GB201009273D0 (en) * 2010-06-03 2010-07-21 Glaxosmithkline Biolog Sa Novel vaccine
EP2624815B8 (fr) * 2010-10-08 2016-09-21 R.P. Scherer Technologies, LLC Forme galénique à dissolution rapide de vaccin oral utilisant de l'amidon
EP2780035A1 (fr) * 2011-11-14 2014-09-24 Novartis AG Complexes immunogènes de carbomères polyanioniques et de polypeptides env et procédés de fabrication et d'utilisation de ceux-ci
JP5650780B2 (ja) * 2012-04-04 2015-01-07 日東電工株式会社 ワクチン組成物
NL2018155B1 (en) 2017-01-11 2018-07-25 Intervet Int Bv Oral vaccine against ruminant respiratory disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59163313A (ja) * 1983-03-09 1984-09-14 Teijin Ltd 経鼻投与用ペプチドホルモン類組成物
DE3601923A1 (de) * 1986-01-23 1987-07-30 Behringwerke Ag Nasal applizierbares arzneimittel, verfahren zu seiner herstellung und seine verwendung
ZA881694B (en) * 1987-03-17 1988-09-06 Akzo N.V. Adjuvant mixture
US4944942A (en) * 1987-08-27 1990-07-31 Mobay Corporation Intranasal vaccination of horses with inactivated microorganisms or antigenic material
US5158761A (en) * 1989-04-05 1992-10-27 Toko Yakuhin Kogyo Kabushiki Kaisha Spray gel base and spray gel preparation using thereof
US5352448A (en) * 1992-07-20 1994-10-04 Purdue Research Foundatioin Oral administration of antigens

Also Published As

Publication number Publication date
AU692440B2 (en) 1998-06-11
CN1120310A (zh) 1996-04-10
JPH08508247A (ja) 1996-09-03
BR9405996A (pt) 1995-12-19
AU6361694A (en) 1994-09-26
WO1994020070A1 (fr) 1994-09-15
EP0688205A1 (fr) 1995-12-27

Similar Documents

Publication Publication Date Title
AU692440B2 (en) Polymeric mucoadhesives in the delivery of immunogens at mucosal surfaces
Moldoveanu et al. Oral immunization with influenza virus in biodegradable microspheres
JP3098401B2 (ja) 経鼻投与用製剤
Almeida et al. Nasal delivery of vaccines
JP3530526B2 (ja) ＨＳＶ糖蛋白質ｇＤおよび３脱アシル化モノホスホリルリピッドＡからなる単純ヘルペスワクチン
CA2400468C (fr) Vaccin antigrippal a base de proteosomes
Esquisabel et al. A new oral vaccine candidate based on the microencapsulation by spray-drying of inactivated Vibrio cholerae
US8182821B2 (en) Flu vaccine admixture of mannan and flu antigen
BRPI0621185A2 (pt) substáncias imunogênicas da mucosa que compreendem um adjuvante a base de ácido poliinosìnico-ácido policitidìlico
US9585955B2 (en) Lipid and nitrous oxide combination as adjuvant for the enhancement of the efficacy of vaccines
KR20140091461A (ko) 전분을 이용한 경구 백신 급속 용해성 투여 형태
CA2801554A1 (fr) Immunisation par voie nasale
Anggraeni et al. Development of mucosal vaccine delivery: an overview on the mucosal vaccines and their adjuvants
Lazzell et al. Immunization against influenza in humans using an oral enteric-coated killed virus vaccine
EP0544612A2 (fr) Composition contenant un immunogène et un triglycéride
US9585954B2 (en) Mucosal immunization
Glück Intranasal immunization against influenza
JP4724000B2 (ja) ポリペプチド
JP2004508424A (ja) 免疫調節調剤物
JP2003528818A (ja) 皮膚経路を介したワクチン接種による粘膜免疫の誘導
US7651842B2 (en) Imunogenic complex comprising ribosomes
JP4889175B2 (ja) 感染性因子に対する免疫応答を刺激するための組成物および方法
Kidane et al. The efficacy of oral vaccination of mice with alginate encapsulated outer membrane proteins of Pasteurella haemolytica and One-Shot®
WO2008037033A1 (fr) Vaccin contre la grippe constitué d'un mélange de mannane et d'antigène de la grippe
Bowen et al. Mucosal delivery of herpes simplex virus vaccine

Legal Events

Date Code Title Description
FZDE Dead