CA2150554A1 - Cyclodextrin and polymer based drug delivery system - Google Patents

Cyclodextrin and polymer based drug delivery system

Info

Publication number
CA2150554A1
CA2150554A1 CA002150554A CA2150554A CA2150554A1 CA 2150554 A1 CA2150554 A1 CA 2150554A1 CA 002150554 A CA002150554 A CA 002150554A CA 2150554 A CA2150554 A CA 2150554A CA 2150554 A1 CA2150554 A1 CA 2150554A1
Authority
CA
Canada
Prior art keywords
alpha
beta
defined above
alkyl
cyclodextrin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002150554A
Other languages
English (en)
French (fr)
Inventor
Sheng-Wan Tsao
Lyle M. Bowman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sun Pharmaceutical Industries Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/984,445 external-priority patent/US5332582A/en
Application filed by Individual filed Critical Individual
Publication of CA2150554A1 publication Critical patent/CA2150554A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002150554A 1992-12-02 1993-12-01 Cyclodextrin and polymer based drug delivery system Abandoned CA2150554A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/984,445 1992-12-02
US07/984,445 US5332582A (en) 1990-06-12 1992-12-02 Stabilization of aminosteroids for topical ophthalmic and other applications
US15516793A 1993-11-19 1993-11-19
US08/155,167 1993-11-19

Publications (1)

Publication Number Publication Date
CA2150554A1 true CA2150554A1 (en) 1994-06-09

Family

ID=26852057

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002150554A Abandoned CA2150554A1 (en) 1992-12-02 1993-12-01 Cyclodextrin and polymer based drug delivery system

Country Status (6)

Country Link
EP (1) EP0674528A4 (zh)
JP (1) JPH08503951A (zh)
CN (1) CN1103316A (zh)
AU (1) AU672862B2 (zh)
CA (1) CA2150554A1 (zh)
WO (1) WO1994012217A1 (zh)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW434023B (en) * 1995-09-18 2001-05-16 Novartis Ag Preserved ophthalmic composition
JP3940209B2 (ja) 1996-11-14 2007-07-04 株式会社資生堂 可溶化化粧料
GB9711643D0 (en) * 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
US6656456B2 (en) 1998-11-23 2003-12-02 The Procter & Gamble Company Skin deodorizing compositions
WO2000030599A1 (en) * 1998-11-23 2000-06-02 The Procter & Gamble Company Skin deodorizing and sanitizing compositions
CA2373237A1 (en) * 2000-03-10 2001-09-20 Insite Vision Incorporated Methods and compositions for treating and preventing posterior segment ophthalmic disorders
AU2001259298A1 (en) 2000-05-02 2001-11-12 Advanced Medicine, Inc. Polyacid glycopeptide derivatives
SI1278549T1 (sl) 2000-05-02 2009-04-30 Theravance Inc Sestavek, ki vsebuje ciklodekstrin in glikopeptidni antibiotik
US6828299B2 (en) 2000-06-22 2004-12-07 Theravance, Inc. Polyhydroxy glycopeptide derivatives
ES2302733T3 (es) 2000-06-22 2008-08-01 Theravance, Inc. Derivados carboxi-sacaridos de glucopeptido.
US6872804B2 (en) 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
AU2001288120A1 (en) * 2000-09-26 2002-04-08 Kyorin Pharmaceutical Co. Ltd. Liquid prednisolone sodium phosphate preparation
CA2445606A1 (en) * 2001-05-11 2002-11-21 Pacific Pharmaceuticals Limited Taste masking pharmaceutical composition
WO2004091630A1 (ja) * 2003-04-18 2004-10-28 Advanced Medicine Research Institute 眼に適用する疾患治療剤
US6933289B2 (en) 2003-07-01 2005-08-23 Allergan, Inc. Inhibition of irritating side effects associated with use of a topical ophthalmic medication
WO2006040839A1 (ja) * 2004-10-15 2006-04-20 Advanced Medicine Research Institute 眼疾患処置用点眼剤及びキット
JP2007177149A (ja) * 2005-12-28 2007-07-12 Shield Lab:Kk チオクト酸又はジヒドロリポ酸と分岐鎖シクロデキストリンとの包接化合物
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
EP2234614B1 (de) 2007-12-21 2012-10-17 AOP Orphan Pharmaceuticals AG Pharmazeutische zusammensetzung zur parenteralen verabreichung eines ultrakurzwirksamen beta-adrenorezeptor antagonisten
US10980818B2 (en) 2009-03-06 2021-04-20 Sun Pharma Global Fze Methods for treating ocular inflammatory diseases
US10201548B2 (en) 2009-03-06 2019-02-12 Sun Pharma Global Fze Methods for treating ocular inflammatory diseases
EP3520749A1 (en) 2010-10-15 2019-08-07 Clearside Biomedical, Inc. Device for ocular access
US20150258120A1 (en) 2012-11-08 2015-09-17 Clearside Biomedical, Inc. Methods and devices for the treatment of ocular diseases in human subjects
US20150374832A1 (en) * 2013-02-12 2015-12-31 Ys Pharm Tech Epinephrine formulations for medicinal products
JP6379183B2 (ja) 2013-05-03 2018-08-22 クリアサイド バイオメディカル,インコーポレイテッド 眼球注射の装置および方法
US10010447B2 (en) 2013-12-18 2018-07-03 Novartis Ag Systems and methods for subretinal delivery of therapeutic agents
CN103990137A (zh) * 2014-04-30 2014-08-20 福建融和药业有限公司 一种粘膜粘附性聚合物眼用药物的缓释剂
US10390901B2 (en) 2016-02-10 2019-08-27 Clearside Biomedical, Inc. Ocular injection kit, packaging, and methods of use
JP2019514581A (ja) 2016-05-02 2019-06-06 クリアサイド バイオメディカル,インコーポレイテッド 眼の薬物送達のためのシステムおよび方法
CN110177527B (zh) 2016-08-12 2022-02-01 科尼尔赛德生物医学公司 用于调节药剂递送用针的插入深度的装置和方法
CN109136177B (zh) * 2018-08-03 2021-09-17 湖南大学 一种地塞米松缓释体系以及一种成骨分化诱导液和应用
RU2740287C1 (ru) * 2019-08-30 2021-01-12 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) 3д-матриксная структура для доставки лекарственных препаратов
CN115380899A (zh) * 2022-08-30 2022-11-25 陕西科技大学 一种凝胶型腐植酸缓释农药及其制备方法
WO2024097388A1 (en) * 2022-11-03 2024-05-10 Arizona Board Of Regents On Behalf Of The University Of Arizona Systems and methods for monitoring fatty acid metabolism

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4383992A (en) * 1982-02-08 1983-05-17 Lipari John M Water-soluble steroid compounds
NZ225045A (en) * 1987-07-01 1990-06-26 Janssen Pharmaceutica Nv Antiviral pharmaceutical compositions containing cyclodextrin and an antiviral agent
US5002935A (en) * 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
IE63392B1 (en) * 1988-02-08 1995-04-19 Insite Vision Inc Ophthalmic suspensions
ES2062359T3 (es) * 1989-05-24 1994-12-16 Innovet Inc Un procedimiento de preparacion de una composicion anestesica o hipnotica esteroidal hipoalergenica.
GB9012663D0 (en) * 1990-06-07 1990-08-01 Erba Carlo Spa Galenic formulations containing cyclodextrins

Also Published As

Publication number Publication date
JPH08503951A (ja) 1996-04-30
AU5684194A (en) 1994-06-22
EP0674528A4 (en) 1996-06-26
EP0674528A1 (en) 1995-10-04
AU672862B2 (en) 1996-10-17
CN1103316A (zh) 1995-06-07
WO1994012217A1 (en) 1994-06-09

Similar Documents

Publication Publication Date Title
CA2150554A1 (en) Cyclodextrin and polymer based drug delivery system
US5538721A (en) Stabilization of aminosteroids for topical ophthalmic and other applications
Loftsson et al. Cyclodextrins and topical drug delivery to the anterior and posterior segments of the eye
Loftssona et al. Cyclodextrins in ophthalmic drug delivery
EP0794783B1 (en) Cyclodextrins as suspending agents for pharmaceutical suspensions
US8633172B2 (en) Cyclodextrin nanotechnology for ophthalmic drug delivery
Loftsson et al. Cyclodextrins in eye drop formulations: enhanced topical delivery of corticosteroids to the eye
EP0730443B1 (en) Suspension of loteprednol etabonate
US20040152664A1 (en) Prednisolone compositions
JPH06239748A (ja) セチリジン含有抗アレルギー点眼点鼻用組成物
US4642305A (en) Eye drops composition
CN102724965B (zh) 含羧乙烯基聚合物的纳米颗粒混悬液
EP1567125A2 (en) Pharmaceutical compositions suitable for the treatment of ophthalmic diseases
US20050059615A1 (en) Transmucosal dosage forms for brain-targeted steroid chemical delivery systems
Patil et al. Advances in progesterone delivery systems: Still work in progress?
US5977180A (en) Anandamide analog compositions and method of treating intraocular hypertension using same
WO2007013590A1 (ja) 固形組成物を用いた後眼部組織への非侵襲性ドラッグデリバリーシステム
JP5087242B2 (ja) ゲル状組成物を用いた後眼部組織への非侵襲性ドラッグデリバリーシステム
JP3147076B2 (ja) ロテプレドノール エタボネート水性懸濁液
CN115837027A (zh) 一种眼用地塞米松药物组合物
TW201932110A (zh) 供每日一次用之苯並咪唑化合物的眼用組成物
Bary Considerations in the use of cyclodextrins in the reformation of ophthalmic suspensions as solutions

Legal Events

Date Code Title Description
FZDE Discontinued