CA2147129A1 - New substituted azetidinones as anti-inflammatory and antidegenerative agents - Google Patents
New substituted azetidinones as anti-inflammatory and antidegenerative agentsInfo
- Publication number
- CA2147129A1 CA2147129A1 CA002147129A CA2147129A CA2147129A1 CA 2147129 A1 CA2147129 A1 CA 2147129A1 CA 002147129 A CA002147129 A CA 002147129A CA 2147129 A CA2147129 A CA 2147129A CA 2147129 A1 CA2147129 A1 CA 2147129A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- hydrogen
- 6alkyl
- methyl
- diethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96679992A | 1992-10-27 | 1992-10-27 | |
| US99219392A | 1992-12-17 | 1992-12-17 | |
| US966,799 | 1992-12-17 | ||
| US992,193 | 1992-12-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2147129A1 true CA2147129A1 (en) | 1994-05-11 |
Family
ID=27130492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002147129A Abandoned CA2147129A1 (en) | 1992-10-27 | 1993-10-26 | New substituted azetidinones as anti-inflammatory and antidegenerative agents |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5952321A (https=) |
| EP (1) | EP0666846A1 (https=) |
| JP (1) | JPH08502752A (https=) |
| AU (1) | AU5587594A (https=) |
| CA (1) | CA2147129A1 (https=) |
| WO (1) | WO1994010143A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2120221A1 (en) * | 1993-04-23 | 1994-10-24 | Allan W. Rey | N-substituted 2-azetidinones |
| WO1997030707A1 (en) | 1996-02-23 | 1997-08-28 | Eli Lilly And Company | NON-PEPTIDYL VASOPRESSIN V1a ANTAGONISTS |
| WO1999004826A1 (en) * | 1997-07-24 | 1999-02-04 | The Australian National University | Method for detection of fibrin clots |
| EP1099690A4 (en) * | 1998-07-23 | 2001-10-17 | Shionogi & Co | MONOCYCLIC BETA LACTAM COMPOUNDS AND CHYMASE INHIBITORS THAT CONTAIN THEM |
| US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| HU230253B1 (hu) | 2001-01-26 | 2015-11-30 | Merck Sharp & Dohme Corp | Peroxiszóma proliferátor-aktivált receptor (PPAR) aktivátor(ok) és szterin-abszorpció inhibitor(ok) kombinációi és alkalmazásuk vaszkuláris indikációk kezelésére |
| DK1355644T3 (da) | 2001-01-26 | 2006-10-23 | Schering Corp | Anvendelse af substituerede azetidinonforbindelser til behandling af sitosterolæmi |
| JP2005504091A (ja) | 2001-09-21 | 2005-02-10 | シェーリング コーポレイション | ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置 |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| WO2004043457A1 (en) | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorptions inhibitors for the treatment of autoimmune disorders |
| JP2006519869A (ja) * | 2003-03-07 | 2006-08-31 | シェーリング コーポレイション | 置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用 |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| CA2517571C (en) | 2003-03-07 | 2011-07-05 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| JP4589919B2 (ja) | 2003-03-07 | 2010-12-01 | シェーリング コーポレイション | 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用 |
| DE10336185A1 (de) * | 2003-08-07 | 2005-02-24 | Bayer Chemicals Ag | Enantiomerenangereicherte 1-Phenylethylamine |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1192952A (en) * | 1967-03-31 | 1970-05-28 | Lepetit Spa | Azetidine-2-One Derivatives |
| DE1906401A1 (de) * | 1969-02-08 | 1970-08-27 | Hoechst Ag | Verfahren zur Herstellung von 4-Acyloxy-azetidin-2-onen |
| BE755940A (fr) * | 1969-09-09 | 1971-03-09 | Hoechst Ag | Azetidinones-2 portant des substituants en position 4 et leur preparation |
| DE2046823A1 (de) * | 1970-09-23 | 1972-03-30 | Farbwerke Hoechst AG vormals Meister Lucius & Brüning, 6000 Frankfurt | Neue Azetidinone-(2) und Verfahren zu deren Herstellung |
| DE2046822A1 (de) * | 1970-09-23 | 1972-03-30 | Farbwerke Hoechst AG, vorm. Meister Lucius & Brüning, 6000 Frankfurt | Neue Azetidinone-(2) und Verfahren zu deren Herstellung |
| US4064120A (en) * | 1976-11-01 | 1977-12-20 | E. R. Squibb & Sons, Inc. | 3,3-Dichloro-2-azetidinone derivatives having antiinflammatory activity |
| US4166907A (en) * | 1976-11-01 | 1979-09-04 | E. R. Squibb & Sons, Inc. | 3,3-Dichloro-2-azetidinone derivatives having antiinflammatory activity |
| LU77306A1 (https=) * | 1977-05-09 | 1979-01-18 | ||
| US4115382A (en) * | 1977-06-06 | 1978-09-19 | E. R. Squibb & Sons, Inc. | 3,3-Dichloro-2-azetidinone derivatives having basic substituents |
| CA1145347A (en) * | 1977-09-30 | 1983-04-26 | Akira Sato | 2-azetidinone derivatives |
| EP0042026B1 (de) * | 1978-02-02 | 1986-01-08 | Ciba-Geigy Ag | 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung |
| US4174317A (en) * | 1978-03-24 | 1979-11-13 | E. R. Squibb & Sons, Inc. | 3,3-Dichloro-2-azetidinone derivatives |
| US4331677A (en) * | 1978-11-24 | 1982-05-25 | Farmitalia Carlo Erba S.P.A. | 7-Oxo-4-1-aza-bicyclo-[3,2,0]-heptane derivatives |
| EP0023097B1 (en) * | 1979-06-28 | 1984-08-01 | Sumitomo Chemical Company, Limited | De-arylmethylation of n-mono- or n-diarylmethyl-beta-lactams; novel azetizinones having anti-bacterial activity |
| US4260743A (en) * | 1979-12-31 | 1981-04-07 | Gist-Brocades N.V. | Preparation of β-lactams and intermediates therefor |
| DE3007298A1 (de) * | 1980-02-27 | 1981-09-03 | Merck Patent Gmbh, 6100 Darmstadt | Verfahren zur herstellung von azetidinonen und deren verwendung |
| HU181742B (en) * | 1980-09-15 | 1983-11-28 | Richter Gedeon Vegyeszet | Process for producing new azetidinone derivatives |
| DE3175042D1 (en) * | 1980-11-06 | 1986-09-04 | Hoechst Uk Ltd | 7-oxo-4-thia-1-aza(3,2,0)heptane and 7-oxo-4-thia-1-aza(3,2,0)hept-2-ene derivatives |
| JPS5857360A (ja) * | 1981-10-01 | 1983-04-05 | Ajinomoto Co Inc | アゼチジノン誘導体 |
| US4534896A (en) * | 1983-06-13 | 1985-08-13 | E. R. Squibb & Sons, Inc. | 3-Acylamino-2-oxoazetidine-1-(β-oxopropionic acid) |
| US4576749A (en) * | 1983-10-03 | 1986-03-18 | E. R. Squibb & Sons, Inc. | 3-Acylamino-1-carboxymethylaminocarbonyl-2-azetidinones |
| US4559335A (en) * | 1983-10-03 | 1985-12-17 | E. R. Squibb & Sons, Inc. | 3-Acylamino-1-carboxymethyloxy (or thio) carbonyl-2-azetidinones |
| US4680391A (en) * | 1983-12-01 | 1987-07-14 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| US5229381A (en) * | 1983-12-01 | 1993-07-20 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| DE3751700D1 (de) * | 1986-11-12 | 1996-03-21 | Merck & Co Inc | Substituierte Cephalosporinsulfone als anti-entzündliche und anti-degenerative Mittel |
| NZ228600A (en) * | 1988-04-11 | 1992-02-25 | Merck & Co Inc | 1-(benzylaminocarbonyl)-4-phenoxy-azetidin-2-one derivatives |
| IL99658A0 (en) * | 1990-10-15 | 1992-08-18 | Merck & Co Inc | Substituted azetidinones and pharmaceutical compositions containing them |
| US5104862A (en) * | 1991-03-20 | 1992-04-14 | Merck & Co., Inc. | Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone |
| WO1993000332A1 (en) * | 1991-06-25 | 1993-01-07 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| US5348953A (en) * | 1991-06-25 | 1994-09-20 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
-
1993
- 1993-10-26 JP JP6511259A patent/JPH08502752A/ja active Pending
- 1993-10-26 AU AU55875/94A patent/AU5587594A/en not_active Abandoned
- 1993-10-26 WO PCT/US1993/010269 patent/WO1994010143A1/en not_active Ceased
- 1993-10-26 CA CA002147129A patent/CA2147129A1/en not_active Abandoned
- 1993-10-26 EP EP94901205A patent/EP0666846A1/en not_active Withdrawn
-
1996
- 1996-12-12 US US08/764,775 patent/US5952321A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU5587594A (en) | 1994-05-24 |
| WO1994010143A1 (en) | 1994-05-11 |
| EP0666846A1 (en) | 1995-08-16 |
| US5952321A (en) | 1999-09-14 |
| JPH08502752A (ja) | 1996-03-26 |
| EP0666846A4 (https=) | 1995-09-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1286304C (en) | Substituted azetidinones as anti-inflammatory and antidegenerative agents | |
| US5229381A (en) | Substituted azetidinones as anti-inflammatory and antidegenerative agents | |
| AU648345B2 (en) | New substituted azetidinones as anti-inflammatory and antidegenerative agents | |
| AU656591B2 (en) | New substituted azetidinones as anti-inflammatory and antidegenerative agents | |
| CA1337990C (en) | Substituted azetidinones as anti-inflammatory antidegenerative agents | |
| US5348953A (en) | Substituted azetidinones as anti-inflammatory and antidegenerative agents | |
| CA2147129A1 (en) | New substituted azetidinones as anti-inflammatory and antidegenerative agents | |
| EP0595557B1 (en) | New substituted azetidinones as anti-inflammatory and antidegenerative agents | |
| GB2266527A (en) | Substituted azetidinones useful in the treatment of leukemia | |
| WO1994013636A1 (en) | New substituted azetidinones as anti-inflammatory and antidegenerative agents | |
| US5747485A (en) | Substituted azetidiones as anti-inflammatory and antidegenerative agents | |
| US5591737A (en) | Substituted azetidinones as anti-inflammatory and antidegenerative agents | |
| HK1008333A (en) | New substituted azetidinones as anti-inflammatory and antidegenerative agents | |
| US20100216761A1 (en) | Novel azetidinones useful as inhibitors of elastase | |
| JPS6094958A (ja) | アゼチジノン類 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |