CA2146000A1 - Derives de substitution en 3,3 d'indolin-2-ones tri- et tetracycliques, utiles pour le traitement de troubles cognitifs - Google Patents

Derives de substitution en 3,3 d'indolin-2-ones tri- et tetracycliques, utiles pour le traitement de troubles cognitifs

Info

Publication number
CA2146000A1
CA2146000A1 CA002146000A CA2146000A CA2146000A1 CA 2146000 A1 CA2146000 A1 CA 2146000A1 CA 002146000 A CA002146000 A CA 002146000A CA 2146000 A CA2146000 A CA 2146000A CA 2146000 A1 CA2146000 A1 CA 2146000A1
Authority
CA
Canada
Prior art keywords
pyr
pyrim
group
carbons
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002146000A
Other languages
English (en)
Inventor
Richard Alan Earl
Melvyn John Myers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2146000A1 publication Critical patent/CA2146000A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
CA002146000A 1992-10-13 1993-10-12 Derives de substitution en 3,3 d'indolin-2-ones tri- et tetracycliques, utiles pour le traitement de troubles cognitifs Abandoned CA2146000A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96052292A 1992-10-13 1992-10-13
US07/960,522 1992-10-13

Publications (1)

Publication Number Publication Date
CA2146000A1 true CA2146000A1 (fr) 1994-04-28

Family

ID=25503278

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002146000A Abandoned CA2146000A1 (fr) 1992-10-13 1993-10-12 Derives de substitution en 3,3 d'indolin-2-ones tri- et tetracycliques, utiles pour le traitement de troubles cognitifs

Country Status (8)

Country Link
EP (1) EP0664810A1 (fr)
JP (1) JPH08502293A (fr)
AU (1) AU6242294A (fr)
CA (1) CA2146000A1 (fr)
IL (1) IL107251A0 (fr)
MX (1) MX9306337A (fr)
WO (1) WO1994009009A1 (fr)
ZA (1) ZA937604B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112624972A (zh) * 2019-09-24 2021-04-09 中国人民解放军军事科学院军事医学研究院 吖啶酮类化合物及医药用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760083A (en) * 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
US5173489A (en) * 1986-04-10 1992-12-22 The Dupont Merck Pharmaceutical Co. α,α-disubstituted aromatics and heteroaromatics as cognition enhancers
US5278045A (en) * 1990-02-28 1994-01-11 Du Pont Merck Pharmaceutical Company Method and compositions to screen compounds for enhancement of the cholinergic, dopaminergic and serotonergic function

Also Published As

Publication number Publication date
EP0664810A1 (fr) 1995-08-02
MX9306337A (es) 1995-01-31
JPH08502293A (ja) 1996-03-12
AU6242294A (en) 1994-05-09
IL107251A0 (en) 1994-01-25
WO1994009009A1 (fr) 1994-04-28
ZA937604B (en) 1995-04-13

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Legal Events

Date Code Title Description
FZDE Discontinued