CA2145775C - 1,4-disubstituted piperazines useful in the therapy of the asthma and of the inflammation of the respiratory tract - Google Patents

1,4-disubstituted piperazines useful in the therapy of the asthma and of the inflammation of the respiratory tract Download PDF

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Publication number
CA2145775C
CA2145775C CA002145775A CA2145775A CA2145775C CA 2145775 C CA2145775 C CA 2145775C CA 002145775 A CA002145775 A CA 002145775A CA 2145775 A CA2145775 A CA 2145775A CA 2145775 C CA2145775 C CA 2145775C
Authority
CA
Canada
Prior art keywords
bis
pyrrolidin
piperazine
formula
pyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002145775A
Other languages
English (en)
French (fr)
Other versions
CA2145775A1 (en
Inventor
Giorgio Long
Silvano Spinelli
Antonella Rozzi
Simonetta D'alo'
Licia Gallico
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2145775A1 publication Critical patent/CA2145775A1/en
Application granted granted Critical
Publication of CA2145775C publication Critical patent/CA2145775C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002145775A 1992-09-30 1993-08-24 1,4-disubstituted piperazines useful in the therapy of the asthma and of the inflammation of the respiratory tract Expired - Fee Related CA2145775C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI922263A IT1255704B (it) 1992-09-30 1992-09-30 Ammine eterocicliche utili nella terapia dell'asma e dell'infiammazione delle vie aeree
ITMI92A002263 1992-09-30
PCT/EP1993/002264 WO1994007856A1 (en) 1992-09-30 1993-08-24 1,4-disubstituted piperazines useful in the therapy of the asthma and of the inflammation of the respiratory tract

Publications (2)

Publication Number Publication Date
CA2145775A1 CA2145775A1 (en) 1994-04-14
CA2145775C true CA2145775C (en) 2002-10-08

Family

ID=11364040

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002145775A Expired - Fee Related CA2145775C (en) 1992-09-30 1993-08-24 1,4-disubstituted piperazines useful in the therapy of the asthma and of the inflammation of the respiratory tract

Country Status (15)

Country Link
US (1) US5607930A (OSRAM)
EP (1) EP0662957B1 (OSRAM)
JP (1) JP3268524B2 (OSRAM)
KR (1) KR100270977B1 (OSRAM)
CN (1) CN1043141C (OSRAM)
AT (1) ATE159937T1 (OSRAM)
AU (1) AU680626B2 (OSRAM)
CA (1) CA2145775C (OSRAM)
DE (1) DE69315085T2 (OSRAM)
ES (1) ES2111175T3 (OSRAM)
IT (1) IT1255704B (OSRAM)
RU (1) RU2119913C1 (OSRAM)
TW (1) TW238305B (OSRAM)
WO (1) WO1994007856A1 (OSRAM)
ZA (1) ZA937147B (OSRAM)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9601697D0 (en) * 1996-01-27 1996-03-27 Pfizer Ltd Therapeutic agents
TW527355B (en) * 1997-07-02 2003-04-11 Bristol Myers Squibb Co Inhibitors of farnesyl protein transferase
JP2000256396A (ja) * 1999-03-03 2000-09-19 Dainippon Pharmaceut Co Ltd 複素環式化合物およびその中間体ならびにエラスターゼ阻害剤
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6809093B2 (en) * 2000-10-17 2004-10-26 H. Lee Moffitt Cancer & Research Institute, Inc. 2-substituted heterocyclic compounds
IL160974A0 (en) * 2001-10-22 2004-08-31 Pfizer Prod Inc Piperazine derivatives with ccr1 receptor antagonist activity
CA2580856A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
AR051094A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
BRPI0515488A (pt) 2004-09-20 2008-07-29 Xenon Pharmaceuticals Inc derivados de heterocìclicos e seu uso como agentes terapêuticos
WO2006101521A2 (en) 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
CA2580787A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
WO2006034338A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase
AU2005286647A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
AU2006343359A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
EP2209376B1 (en) * 2007-10-11 2013-03-06 GlaxoSmithKline LLC Novel seh inhibitors and their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0788357B2 (ja) * 1986-10-27 1995-09-27 吉富製薬株式会社 ピペラジン化合物
FR2663026B1 (fr) * 1990-06-07 1992-08-07 Synthelabo Derives de [(1-arylpyrrolidin-2-yl) methyl] piperazine, leur preparation et leur application en therapeutique.
US5393753A (en) * 1990-10-10 1995-02-28 Schering Corporation Substituted imidazobenzazepines
IT1245712B (it) * 1991-04-09 1994-10-14 Boehringer Mannheim Italia Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree
JPH08291987A (ja) * 1995-04-20 1996-11-05 Hitachi Ltd 冷蔵庫

Also Published As

Publication number Publication date
DE69315085T2 (de) 1998-03-26
CN1088580A (zh) 1994-06-29
ES2111175T3 (es) 1998-03-01
US5607930A (en) 1997-03-04
ITMI922263A1 (it) 1994-03-30
CN1043141C (zh) 1999-04-28
AU4951893A (en) 1994-04-26
AU680626B2 (en) 1997-08-07
ZA937147B (en) 1994-05-18
IT1255704B (it) 1995-11-10
WO1994007856A1 (en) 1994-04-14
RU95112577A (ru) 1997-01-10
EP0662957B1 (en) 1997-11-05
JPH08501573A (ja) 1996-02-20
ITMI922263A0 (it) 1992-09-30
RU2119913C1 (ru) 1998-10-10
EP0662957A1 (en) 1995-07-19
ATE159937T1 (de) 1997-11-15
DE69315085D1 (de) 1997-12-11
CA2145775A1 (en) 1994-04-14
TW238305B (OSRAM) 1995-01-11
JP3268524B2 (ja) 2002-03-25
KR100270977B1 (ko) 2000-11-01

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