CA2140260A1 - 4-(4-fluorophenylmethyl)-piperidines having sigma and d2-receptor affinity - Google Patents

4-(4-fluorophenylmethyl)-piperidines having sigma and d2-receptor affinity

Info

Publication number
CA2140260A1
CA2140260A1 CA002140260A CA2140260A CA2140260A1 CA 2140260 A1 CA2140260 A1 CA 2140260A1 CA 002140260 A CA002140260 A CA 002140260A CA 2140260 A CA2140260 A CA 2140260A CA 2140260 A1 CA2140260 A1 CA 2140260A1
Authority
CA
Canada
Prior art keywords
compound
formula
pharmaceutically acceptable
compounds
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002140260A
Other languages
English (en)
French (fr)
Inventor
Rafael Foquet
Jordi Bolos
Aurelio Sacristan
Jose Ortiz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferrer Internacional SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2140260A1 publication Critical patent/CA2140260A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002140260A 1993-05-18 1994-05-17 4-(4-fluorophenylmethyl)-piperidines having sigma and d2-receptor affinity Abandoned CA2140260A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP9301062 1993-05-18
ES09301062A ES2066721B1 (es) 1993-05-18 1993-05-18 Nuevos compuestos derivados de la piridina 1,4-disustituida.

Publications (1)

Publication Number Publication Date
CA2140260A1 true CA2140260A1 (en) 1994-11-24

Family

ID=8281846

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002140260A Abandoned CA2140260A1 (en) 1993-05-18 1994-05-17 4-(4-fluorophenylmethyl)-piperidines having sigma and d2-receptor affinity

Country Status (12)

Country Link
EP (1) EP0651744A1 (enrdf_load_stackoverflow)
JP (1) JPH07509255A (enrdf_load_stackoverflow)
KR (1) KR950702535A (enrdf_load_stackoverflow)
AU (1) AU675332B2 (enrdf_load_stackoverflow)
CA (1) CA2140260A1 (enrdf_load_stackoverflow)
ES (1) ES2066721B1 (enrdf_load_stackoverflow)
FI (1) FI950197L (enrdf_load_stackoverflow)
NO (1) NO301638B1 (enrdf_load_stackoverflow)
NZ (1) NZ267100A (enrdf_load_stackoverflow)
TW (1) TW252975B (enrdf_load_stackoverflow)
WO (1) WO1994026712A1 (enrdf_load_stackoverflow)
ZA (1) ZA943036B (enrdf_load_stackoverflow)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1999000149A (es) 1998-09-09 2000-01-12 Pfizer Prod Inc Derivados de 4,4-biarilpiperidina

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3576810A (en) * 1968-06-20 1971-04-27 Robins Co Inc A H 1-substituted-3-(-4)-aroylpiperidines
SE7409245L (enrdf_load_stackoverflow) * 1973-07-19 1975-01-20 Robins Co Inc A H
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
FR2681319B1 (fr) * 1991-09-12 1995-02-17 Synthelabo Derives de 1-(phenoxyalkyl)piperidine, leur preparation et leur application en therapeutique.
ES2060547B1 (es) * 1992-06-04 1995-06-16 Ferrer Int Mejoras en el objeto de la patente de invencion n/ 9201158 que se refiere a "procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina".

Also Published As

Publication number Publication date
ES2066721A1 (es) 1995-03-01
FI950197A7 (fi) 1995-01-17
NO301638B1 (no) 1997-11-24
EP0651744A1 (en) 1995-05-10
NO950062L (no) 1995-01-06
FI950197A0 (fi) 1995-01-17
ZA943036B (en) 1995-05-02
AU6928494A (en) 1994-12-12
WO1994026712A1 (en) 1994-11-24
NO950062D0 (no) 1995-01-06
FI950197L (fi) 1995-01-17
JPH07509255A (ja) 1995-10-12
KR950702535A (ko) 1995-07-29
ES2066721B1 (es) 1996-02-16
TW252975B (enrdf_load_stackoverflow) 1995-08-01
AU675332B2 (en) 1997-01-30
NZ267100A (en) 1996-09-25

Similar Documents

Publication Publication Date Title
CA1072562A (en) 1-substituted-4-benzylidenepiperidines
NL8000754A (nl) Nieuwe gesubstitueerde piperidine-derivaten met thera- peutische werking, preparaten die deze nieuwe stoffen bevatten, alsmede werkwijze voor de bereiding en toe- passing daarvan.
AU2004281216A1 (en) Derivatives of n-[phenyl(alkylpiperidine-2-yl)methyl]benzamide, preparation method thereof and application of same in therapeutics
EP0755923A1 (en) Ameliorant or remedy for symptoms caused by ischemic diseases and compounds useful therefor
DE69830045T2 (de) Arylpiperidinopropanol und Arylpiperazinopropanol Derivate und dieselbe ent- haltende Pharmazeutika
KR100360954B1 (ko) 페닐알칸올아민유도체,이의제조방법및이를함유하는신경변성질환억제또는예방용약제
US6303627B1 (en) Inhibitors of serotonin reuptake
Germann et al. Paroxetine hydrochloride
US5231092A (en) Hexahydroazepine derivatives and pharmaceutical compositions containing them
US6225324B1 (en) Antidepressant heterocyclic compounds
CA2140260A1 (en) 4-(4-fluorophenylmethyl)-piperidines having sigma and d2-receptor affinity
EP1189886B1 (en) Ethanesulfonyl-piperidine derivatives
EP0660819B1 (en) New n,n,n',n'-tetrasubstituted-1,2-ethanediamine derivative compounds
US5290796A (en) Substituted 3-piperidinealkanamines and alkanamides and compositions and method of use thereof
WO1995011238A1 (en) Heterocyclic amines for treating ischaemic strokes
EP0034647B1 (en) 4-aryloxy-3-phenylpiperidine derivatives, intermediates, a process for the preparation of such compounds and their use as medicaments
CA1148150A (en) Phenylmorphans, intermediates and method of preparation
AU2006243709A1 (en) Substituted butyrophenone derivatives
DE69904626T2 (de) Aryl-4-fluoro-4-(2-pyridin-2-yl-ethylamino)-methyl]-piperidin-1-yl-methanone derivate als 5-ht1-rezeptor-agonisten
EP1370529B1 (de) Substituierte dimethyl 1-(1-phenyl-cyclohexyl)-piperidin-3-ylmethyl!-amine und verwendung als analgetika
US5098925A (en) Spiro-dihydroisoindole compounds
AU781715B2 (en) Process for the preparation of the mesylate salt trihydrate of 1-(4-hydroxyphenyl)-2- (4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol and intermediates useful therefor
EP2357171A1 (en) Piperidine derivative, piperazine derivative and agent for treatment of disease involving central nervous system disorders
US5286733A (en) Substituted 3-piperidinealkanoates and alkanones and compositions and method of use thereof
EP0789021A1 (en) Hydroxamic acid compounds as opioid kappa receptor agonists

Legal Events

Date Code Title Description
FZDE Discontinued