WO1994026712A1 - 4-(4-fluorophenylmethyl)-piperidines having sigma and d2-receptor affinity - Google Patents

4-(4-fluorophenylmethyl)-piperidines having sigma and d2-receptor affinity Download PDF

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Publication number
WO1994026712A1
WO1994026712A1 PCT/EP1994/001594 EP9401594W WO9426712A1 WO 1994026712 A1 WO1994026712 A1 WO 1994026712A1 EP 9401594 W EP9401594 W EP 9401594W WO 9426712 A1 WO9426712 A1 WO 9426712A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
formula
compounds
fluorophenyl
pharmaceutically acceptable
Prior art date
Application number
PCT/EP1994/001594
Other languages
English (en)
French (fr)
Inventor
Rafael Foquet
Jordi BOLÓS
Aurelio Sacristán
José ORTIZ
Original Assignee
Ferrer Internacional, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Internacional, S.A. filed Critical Ferrer Internacional, S.A.
Priority to EP94917641A priority Critical patent/EP0651744A1/en
Priority to KR1019950700196A priority patent/KR950702535A/ko
Priority to FI950197A priority patent/FI950197L/fi
Priority to JP6524990A priority patent/JPH07509255A/ja
Priority to AU69284/94A priority patent/AU675332B2/en
Publication of WO1994026712A1 publication Critical patent/WO1994026712A1/en
Priority to NO950062A priority patent/NO301638B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Definitions

  • No. 4929734 describes the preparation of N-substituted 1- (1,2,3,6-tetrahydro-3-piridinyl)oximes and N-substituted 1-(1,2,3,6-tetrahydro-4-piridinyl)oximes and their use in treating depression, psychosis and/or inflammatory diseases.
  • US Patent No. 5061728 describes the use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in treating psychosis and inflammation and their use as immunosupressants.
  • Irwin test It consists in a package of tests intended to find out the properties of a compound as well as the magnitude of such properties which are completely unknown.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/EP1994/001594 1993-05-18 1994-05-17 4-(4-fluorophenylmethyl)-piperidines having sigma and d2-receptor affinity WO1994026712A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP94917641A EP0651744A1 (en) 1993-05-18 1994-05-17 4-(4-fluorophenylmethyl)-piperidines having sigma and d2-receptor affinity
KR1019950700196A KR950702535A (ko) 1993-05-18 1994-05-17 시그마 및 d₂-수용체 친화성을 가진 4-(4-플루오로페닐메틸)-피페리딘(4-(4-fluorophenylmethyl)-piperidines having sigma and d2-peceptor affinity)
FI950197A FI950197L (fi) 1993-05-18 1994-05-17 4-(4-fluorofenyylimetyyli)-piperidiini, jolla on sigma ja D2-reseptori affiniteetti
JP6524990A JPH07509255A (ja) 1993-05-18 1994-05-17 シグマレセプター及びｄ↓２レセプター親和性を有する４−（４−フルオロフェニルメチル）−ピペリジン
AU69284/94A AU675332B2 (en) 1993-05-18 1994-05-17 4-(4-fluorophenylmethyl)-piperidines having sigma and D2-receptor affinity
NO950062A NO301638B1 (no) 1993-05-18 1995-01-06 4-(4-fluorfenylmetyl)-piperidiner med sigma- og D2-reseptoraffinitet og deres anvendelse

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP9301062 1993-05-18
ES09301062A ES2066721B1 (es) 1993-05-18 1993-05-18 Nuevos compuestos derivados de la piridina 1,4-disustituida.

Publications (1)

Publication Number Publication Date
WO1994026712A1 true WO1994026712A1 (en) 1994-11-24

Family

ID=8281846

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1994/001594 WO1994026712A1 (en) 1993-05-18 1994-05-17 4-(4-fluorophenylmethyl)-piperidines having sigma and d2-receptor affinity

Country Status (12)

Country Link
EP (1) EP0651744A1 (enrdf_load_stackoverflow)
JP (1) JPH07509255A (enrdf_load_stackoverflow)
KR (1) KR950702535A (enrdf_load_stackoverflow)
AU (1) AU675332B2 (enrdf_load_stackoverflow)
CA (1) CA2140260A1 (enrdf_load_stackoverflow)
ES (1) ES2066721B1 (enrdf_load_stackoverflow)
FI (1) FI950197L (enrdf_load_stackoverflow)
NO (1) NO301638B1 (enrdf_load_stackoverflow)
NZ (1) NZ267100A (enrdf_load_stackoverflow)
TW (1) TW252975B (enrdf_load_stackoverflow)
WO (1) WO1994026712A1 (enrdf_load_stackoverflow)
ZA (1) ZA943036B (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000014066A1 (en) * 1998-09-09 2000-03-16 Pfizer Products Inc. 4,4-biarylpiperidine derivatives with opioid receptor activity

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3576810A (en) * 1968-06-20 1971-04-27 Robins Co Inc A H 1-substituted-3-(-4)-aroylpiperidines
EP0229391A1 (en) * 1985-12-27 1987-07-22 Eisai Co., Ltd. Piperidine derivate, its use and pharmaceutical composition containing it
FR2681319A1 (fr) * 1991-09-12 1993-03-19 Synthelabo Derives de 1-(phenoxyalkyl)piperidine, leur preparation et leur application en therapeutique.
EP0572952A1 (en) * 1992-06-04 1993-12-08 Ferrer Internacional, S.A. 4-Benzylpiperidine derivatives, a process for preparing them and pharmaceutical compositions containing them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7409245L (enrdf_load_stackoverflow) * 1973-07-19 1975-01-20 Robins Co Inc A H
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3576810A (en) * 1968-06-20 1971-04-27 Robins Co Inc A H 1-substituted-3-(-4)-aroylpiperidines
EP0229391A1 (en) * 1985-12-27 1987-07-22 Eisai Co., Ltd. Piperidine derivate, its use and pharmaceutical composition containing it
FR2681319A1 (fr) * 1991-09-12 1993-03-19 Synthelabo Derives de 1-(phenoxyalkyl)piperidine, leur preparation et leur application en therapeutique.
EP0572952A1 (en) * 1992-06-04 1993-12-08 Ferrer Internacional, S.A. 4-Benzylpiperidine derivatives, a process for preparing them and pharmaceutical compositions containing them

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000014066A1 (en) * 1998-09-09 2000-03-16 Pfizer Products Inc. 4,4-biarylpiperidine derivatives with opioid receptor activity
US6720336B2 (en) 1998-09-09 2004-04-13 Pfizer, Inc. 4,4-biarylpiperidine derivatives

Also Published As

Publication number Publication date
NZ267100A (en) 1996-09-25
JPH07509255A (ja) 1995-10-12
ES2066721A1 (es) 1995-03-01
NO301638B1 (no) 1997-11-24
NO950062D0 (no) 1995-01-06
KR950702535A (ko) 1995-07-29
EP0651744A1 (en) 1995-05-10
ZA943036B (en) 1995-05-02
NO950062L (no) 1995-01-06
FI950197A7 (fi) 1995-01-17
TW252975B (enrdf_load_stackoverflow) 1995-08-01
FI950197A0 (fi) 1995-01-17
FI950197L (fi) 1995-01-17
CA2140260A1 (en) 1994-11-24
ES2066721B1 (es) 1996-02-16
AU675332B2 (en) 1997-01-30
AU6928494A (en) 1994-12-12

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