CA2139350A1 - Produits derives de l'oxazolone - Google Patents

Produits derives de l'oxazolone

Info

Publication number
CA2139350A1
CA2139350A1 CA002139350A CA2139350A CA2139350A1 CA 2139350 A1 CA2139350 A1 CA 2139350A1 CA 002139350 A CA002139350 A CA 002139350A CA 2139350 A CA2139350 A CA 2139350A CA 2139350 A1 CA2139350 A1 CA 2139350A1
Authority
CA
Canada
Prior art keywords
group
different
chemical bond
oxazolone
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002139350A
Other languages
English (en)
Inventor
Joseph C. Hogan, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arqule Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2139350A1 publication Critical patent/CA2139350A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/42—One oxygen atom attached in position 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002139350A 1992-06-30 1993-06-30 Produits derives de l'oxazolone Abandoned CA2139350A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US041,562 1987-04-23
US90675692A 1992-06-30 1992-06-30
US906,756 1992-06-30
US4156293A 1993-04-02 1993-04-02

Publications (1)

Publication Number Publication Date
CA2139350A1 true CA2139350A1 (fr) 1994-01-06

Family

ID=26718293

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002139350A Abandoned CA2139350A1 (fr) 1992-06-30 1993-06-30 Produits derives de l'oxazolone

Country Status (7)

Country Link
EP (1) EP0649443A4 (fr)
JP (1) JPH08500576A (fr)
KR (1) KR950702216A (fr)
AU (1) AU678168B2 (fr)
BR (1) BR9306656A (fr)
CA (1) CA2139350A1 (fr)
WO (1) WO1994000509A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017903A1 (fr) * 1993-12-28 1995-07-06 Arqule Partners, L.P. Structure et synthese modulaire de molecules derivees de l'oxazolone
AU704878B2 (en) * 1994-01-05 1999-05-06 Arqule, Inc. Method of making polymers having specific properties
DE19714343A1 (de) * 1997-04-08 1998-10-15 Bayer Ag Chromatographische Enantiomerentrennung von Lactonen
GB9812675D0 (en) * 1998-06-11 1998-08-12 Univ Edinburgh Peptides
AU3841500A (en) * 1999-04-22 2000-11-10 Sankyo Company Limited Resin-bearing ketoamides and process for the preparation thereof
EP2113510A1 (fr) 2008-04-30 2009-11-04 Freie Universität Berlin Dérivés de pepstatine A
CN112898218B (zh) * 2020-01-14 2022-08-26 河南师范大学 一锅法合成含三氟甲基噁唑酮类化合物的方法
CN112830882A (zh) * 2020-12-31 2021-05-25 河南绿园药业有限公司 一种对羟基苯甘氨酸甲酯合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4125519A (en) * 1976-10-13 1978-11-14 Murray Goodman Polypeptides containing 3,4-dihydroxyphenylalanine
DE2819277A1 (de) * 1977-05-16 1978-11-23 Sandoz Ag Neue polypeptidderivate, ihre herstellung und verwendung
DE2834607A1 (de) * 1978-08-07 1980-02-28 Basf Ag Verfahren zur herstellung von indoleninen
US4485236A (en) * 1982-09-27 1984-11-27 Minnesota Mining And Manufacturing Company Azlactone-functional compounds
JPS60215657A (ja) * 1984-04-10 1985-10-29 Mitsui Toatsu Chem Inc Ｎ−アシルフエニルアラニン類の製造法
US4910277A (en) * 1988-02-09 1990-03-20 Bambury Ronald E Hydrophilic oxygen permeable polymers
US4996292A (en) * 1989-06-30 1991-02-26 Fox Sidney W Self-sealing artificial skin comprising copoly-alpha-amino acid
US5157108A (en) * 1989-12-12 1992-10-20 Minnesota Mining And Manufacturing Company Thermally sensitive linkages
US5149806A (en) * 1990-03-28 1992-09-22 Minnesota Mining And Manufacturing Company Azlactone michael adducts
US5039813A (en) * 1990-06-29 1991-08-13 Polaroid Corporation 2-(4-alkenylphenyl)-5-oxazolones and polymers thereof
JP3190431B2 (ja) * 1991-07-01 2001-07-23 三菱化学株式会社 ケトン誘導体
US5219731A (en) * 1991-11-01 1993-06-15 Wisconsin Alumni Research Foundation Method for preparing optically-active amino acid derivatives

Also Published As

Publication number Publication date
BR9306656A (pt) 1998-12-08
AU4659193A (en) 1994-01-24
EP0649443A1 (fr) 1995-04-26
AU678168B2 (en) 1997-05-22
KR950702216A (ko) 1995-06-19
EP0649443A4 (fr) 1995-11-08
JPH08500576A (ja) 1996-01-23
WO1994000509A1 (fr) 1994-01-06

Similar Documents

Publication Publication Date Title
AU685752B2 (en) Aminimide-containing molecules and materials as molecular recognition agents
AU704183B2 (en) Systematic modular production of aminimide- and oxazolone-based molecules having selected properties
US5811387A (en) Peptoid mixtures
US6271195B1 (en) Aminimide-containing molecules and materials as molecular recognition agents
EP2627662B1 (fr) Procédés de préparation de macrocycles et peptides stabilisés par des macrocycles
CA2085118A1 (fr) Peptide modifie et bibliotheques de peptides resistant a la protease, derives de ces peptides et methodes de production et de detection de ces peptides
Sureshbabu et al. Preparation, isolation, and characterization of N α-Fmoc-peptide isocyanates: Solution synthesis of oligo-α-peptidyl ureas
WO1997040030A1 (fr) Phase solide et synthese combinatoire de 2-methylene-2,3-dihydrothiazoles substitues, et reseaux de 2-methylene-2,3-dihydrothiazoles substitues
CA2139350A1 (fr) Produits derives de l'oxazolone
WO1994000509A9 (fr) Matieres derivees d'oxazolone
US8895739B2 (en) Acylation of hindered amines and functionalized bis-peptides obtained thereby
AU689764B2 (en) Modular design and synthesis of aminimide containing molecules
WO1995017903A1 (fr) Structure et synthese modulaire de molecules derivees de l'oxazolone
EP0743857A1 (fr) Procede de preparation de polymeres ayant des proprietes specifiques
Koppitz et al. Synthesis of Unnatural Lipohilic N‐(9H‐Fluoren‐9‐ylmethoxy) carbonyl‐Substituted α‐Amino Acids and Their Incorporation into Cyclic RGD‐Peptides: A structure‐activity study
US5962412A (en) Method of making polymers having specific properties
US6245937B1 (en) Liquid phase parallel synthesis of chemical libraries
Wieland The history of peptide chemistry
US7034110B2 (en) Method of identifying chemical compounds having selected properties for a particular application
CA2179984A1 (fr) Structure et synthese modulaire de molecules derivees de l'oxazolone
CA2180527A1 (fr) Procede de preparation de polymeres ayant des proprietes specifiques
JPH03123483A (ja) カルボキシル基の修飾方法

Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 20010703