AU678168B2 - Oxazolone derived materials - Google Patents

Oxazolone derived materials Download PDF

Info

Publication number
AU678168B2
AU678168B2 AU46591/93A AU4659193A AU678168B2 AU 678168 B2 AU678168 B2 AU 678168B2 AU 46591/93 A AU46591/93 A AU 46591/93A AU 4659193 A AU4659193 A AU 4659193A AU 678168 B2 AU678168 B2 AU 678168B2
Authority
AU
Australia
Prior art keywords
group
compound
oxazolone
chemical bond
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU46591/93A
Other languages
English (en)
Other versions
AU4659193A (en
Inventor
Joseph C. Hogan Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arqule Inc
Original Assignee
LEGOMER PARTNERS LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LEGOMER PARTNERS LP filed Critical LEGOMER PARTNERS LP
Publication of AU4659193A publication Critical patent/AU4659193A/en
Application granted granted Critical
Publication of AU678168B2 publication Critical patent/AU678168B2/en
Assigned to ARQULE PARTNERS, L.P. reassignment ARQULE PARTNERS, L.P. Alteration of Name(s) of Applicant(s) under S113 Assignors: LEGOMER PARTNERS, L.P.
Assigned to ARQULE, INC. reassignment ARQULE, INC. Alteration of Name(s) in Register under S187 Assignors: ARQULE PARTNERS, L.P.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/42—One oxygen atom attached in position 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AU46591/93A 1992-06-30 1993-06-30 Oxazolone derived materials Ceased AU678168B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US90675692A 1992-06-30 1992-06-30
US906756 1992-06-30
US4156293A 1993-04-02 1993-04-02
US041562 1993-04-02
PCT/US1993/006240 WO1994000509A1 (fr) 1992-06-30 1993-06-30 Matieres derivees d'oxazolone

Publications (2)

Publication Number Publication Date
AU4659193A AU4659193A (en) 1994-01-24
AU678168B2 true AU678168B2 (en) 1997-05-22

Family

ID=26718293

Family Applications (1)

Application Number Title Priority Date Filing Date
AU46591/93A Ceased AU678168B2 (en) 1992-06-30 1993-06-30 Oxazolone derived materials

Country Status (7)

Country Link
EP (1) EP0649443A4 (fr)
JP (1) JPH08500576A (fr)
KR (1) KR950702216A (fr)
AU (1) AU678168B2 (fr)
BR (1) BR9306656A (fr)
CA (1) CA2139350A1 (fr)
WO (1) WO1994000509A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017903A1 (fr) * 1993-12-28 1995-07-06 Arqule Partners, L.P. Structure et synthese modulaire de molecules derivees de l'oxazolone
EP0743857A4 (fr) * 1994-01-05 1998-07-15 Arqule Inc Procede de preparation de polymeres ayant des proprietes specifiques
DE19714343A1 (de) * 1997-04-08 1998-10-15 Bayer Ag Chromatographische Enantiomerentrennung von Lactonen
GB9812675D0 (en) * 1998-06-11 1998-08-12 Univ Edinburgh Peptides
AU3841500A (en) * 1999-04-22 2000-11-10 Sankyo Company Limited Resin-bearing ketoamides and process for the preparation thereof
EP2113510A1 (fr) * 2008-04-30 2009-11-04 Freie Universität Berlin Dérivés de pepstatine A
CN112898218B (zh) * 2020-01-14 2022-08-26 河南师范大学 一锅法合成含三氟甲基噁唑酮类化合物的方法
CN112830882A (zh) * 2020-12-31 2021-05-25 河南绿园药业有限公司 一种对羟基苯甘氨酸甲酯合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4125519A (en) * 1976-10-13 1978-11-14 Murray Goodman Polypeptides containing 3,4-dihydroxyphenylalanine
US5039813A (en) * 1990-06-29 1991-08-13 Polaroid Corporation 2-(4-alkenylphenyl)-5-oxazolones and polymers thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2819277A1 (de) * 1977-05-16 1978-11-23 Sandoz Ag Neue polypeptidderivate, ihre herstellung und verwendung
DE2834607A1 (de) * 1978-08-07 1980-02-28 Basf Ag Verfahren zur herstellung von indoleninen
US4485236A (en) * 1982-09-27 1984-11-27 Minnesota Mining And Manufacturing Company Azlactone-functional compounds
JPS60215657A (ja) * 1984-04-10 1985-10-29 Mitsui Toatsu Chem Inc Ｎ−アシルフエニルアラニン類の製造法
US4910277A (en) * 1988-02-09 1990-03-20 Bambury Ronald E Hydrophilic oxygen permeable polymers
US4996292A (en) * 1989-06-30 1991-02-26 Fox Sidney W Self-sealing artificial skin comprising copoly-alpha-amino acid
US5157108A (en) * 1989-12-12 1992-10-20 Minnesota Mining And Manufacturing Company Thermally sensitive linkages
US5149806A (en) * 1990-03-28 1992-09-22 Minnesota Mining And Manufacturing Company Azlactone michael adducts
JP3190431B2 (ja) * 1991-07-01 2001-07-23 三菱化学株式会社 ケトン誘導体
US5219731A (en) * 1991-11-01 1993-06-15 Wisconsin Alumni Research Foundation Method for preparing optically-active amino acid derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4125519A (en) * 1976-10-13 1978-11-14 Murray Goodman Polypeptides containing 3,4-dihydroxyphenylalanine
US5039813A (en) * 1990-06-29 1991-08-13 Polaroid Corporation 2-(4-alkenylphenyl)-5-oxazolones and polymers thereof

Also Published As

Publication number Publication date
WO1994000509A1 (fr) 1994-01-06
EP0649443A4 (fr) 1995-11-08
KR950702216A (ko) 1995-06-19
CA2139350A1 (fr) 1994-01-06
JPH08500576A (ja) 1996-01-23
BR9306656A (pt) 1998-12-08
EP0649443A1 (fr) 1995-04-26
AU4659193A (en) 1994-01-24

Similar Documents

Publication Publication Date Title
AU685752B2 (en) Aminimide-containing molecules and materials as molecular recognition agents
EP0535155B1 (fr) Banques de peptides modifies resistant a la protease
US5811387A (en) Peptoid mixtures
Gravert et al. Organic synthesis on soluble polymer supports: liquid-phase methodologies
AU704183B2 (en) Systematic modular production of aminimide- and oxazolone-based molecules having selected properties
US6271195B1 (en) Aminimide-containing molecules and materials as molecular recognition agents
AU678168B2 (en) Oxazolone derived materials
WO1994000509A9 (fr) Matieres derivees d'oxazolone
AU689764B2 (en) Modular design and synthesis of aminimide containing molecules
Oki et al. The Resolution of N-Benzyloxycarbonyl-DL-amino Acids Using Ephedrine
US5648462A (en) Peptide purification method using novel linker and solid-phase ligand
WO1995017903A1 (fr) Structure et synthese modulaire de molecules derivees de l'oxazolone
WO1995018627A1 (fr) Procede de preparation de polymeres ayant des proprietes specifiques
US6245937B1 (en) Liquid phase parallel synthesis of chemical libraries
JP2525253B2 (ja) 単一の分子量を有するアミノ酸オリゴマ―の酵素的合成方法
US7034110B2 (en) Method of identifying chemical compounds having selected properties for a particular application
CA2179984A1 (fr) Structure et synthese modulaire de molecules derivees de l'oxazolone
MEYERS A NOVEL USE OF ENZYMES AS REAGENTS IN PEPTIDE SYNTHESIS: ENZYMATIC REMOVAL OF AMINE PROTECTING GROUPS.
CA2180527A1 (fr) Procede de preparation de polymeres ayant des proprietes specifiques

Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired