CA2136324A1 - 5'-indolinyl oxazolidinones useful against mycobacterium tuberculosis - Google Patents
5'-indolinyl oxazolidinones useful against mycobacterium tuberculosisInfo
- Publication number
- CA2136324A1 CA2136324A1 CA002136324A CA2136324A CA2136324A1 CA 2136324 A1 CA2136324 A1 CA 2136324A1 CA 002136324 A CA002136324 A CA 002136324A CA 2136324 A CA2136324 A CA 2136324A CA 2136324 A1 CA2136324 A1 CA 2136324A1
- Authority
- CA
- Canada
- Prior art keywords
- indolinyl
- oxazolidinone
- acetamidomethyl
- mixture
- oxazolidinones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 241000187479 Mycobacterium tuberculosis Species 0.000 title claims 2
- 201000008827 tuberculosis Diseases 0.000 claims abstract description 30
- 239000003814 drug Substances 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 2
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- 150000001875 compounds Chemical class 0.000 description 29
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- 238000000034 method Methods 0.000 description 23
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- 239000007787 solid Substances 0.000 description 11
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- 150000002924 oxiranes Chemical class 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 description 1
- 125000005543 phthalimide group Chemical group 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 230000000707 stereoselective effect Effects 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90938792A | 1992-07-08 | 1992-07-08 | |
| US909,387 | 1992-07-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2136324A1 true CA2136324A1 (en) | 1994-01-20 |
Family
ID=25427164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002136324A Abandoned CA2136324A1 (en) | 1992-07-08 | 1993-05-26 | 5'-indolinyl oxazolidinones useful against mycobacterium tuberculosis |
Country Status (9)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
| GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
| GB9609919D0 (en) | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
| GB9717807D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
| WO1999064417A2 (en) | 1998-06-05 | 1999-12-16 | Astrazeneca Ab | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them |
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| AR038536A1 (es) | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
| US7141588B2 (en) | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
| JP2005537301A (ja) | 2002-08-12 | 2005-12-08 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | Ｎ−アリール−２−オキサゾリジノン類及びそれらの誘導体 |
| DE60309504T2 (de) | 2002-11-21 | 2007-05-16 | Pharmacia & Upjohn Co. Llc, Kalamazoo | N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinon-5-carbosäureamid-derivate und verwandte verbindungen als antibakterielle mittel |
| US7304050B2 (en) | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
| JP2023531666A (ja) | 2020-06-18 | 2023-07-25 | アカゲラ・メディスンズ，インコーポレイテッド | オキサゾリジノン化合物、オキサゾリジノン化合物を含むリポソーム組成物、およびそれらの使用方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5314792A (en) * | 1976-07-24 | 1978-02-09 | Rubuobuna Buratsurabusukay Ara | Copolymers of nnvinylmethylpyrazol and diivinyl crossslinking agent and process for producing same |
| JPS54110186A (en) * | 1978-02-17 | 1979-08-29 | Tokyo Yuuki Kagaku Kougiyou Kk | Method of mamufacturing weak basic anion exchange resin |
| DE3324835A1 (de) * | 1983-07-09 | 1985-01-17 | Cassella Ag, 6000 Frankfurt | Vernetztes copolymerisat, verfahren zu seiner herstellung und seine verwendung als sorptionsmittel |
| JPS6023854A (ja) * | 1983-07-19 | 1985-02-06 | Konishiroku Photo Ind Co Ltd | 写真要素 |
| DE3434137A1 (de) * | 1984-09-18 | 1986-03-20 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von unloeslichen, nur wenig quellbaren pulverfoermigen polymeren |
| JPS63130605A (ja) * | 1986-11-20 | 1988-06-02 | Tokuyama Soda Co Ltd | 陰イオン交換体の製造方法 |
| US4889632A (en) * | 1987-12-10 | 1989-12-26 | Ceskoslovenska Akademie Ved | Macroporous polymeric membranes for the separation of polymers and a method of their application |
| JP2865211B2 (ja) * | 1988-09-15 | 1999-03-08 | ファルマシア・アンド・アップジョン・カンパニー | ５’―インドリニル―５β―アミドメチルオキサゾリジン―２―オン類、３―（縮合環置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類および３―（窒素原子置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類 |
| GB8829835D0 (en) * | 1988-12-21 | 1989-02-15 | Smith Kline French Lab | Compounds |
| JPH03708A (ja) * | 1989-05-29 | 1991-01-07 | Koei Chem Co Ltd | 吸水性材料 |
-
1993
- 1993-05-26 KR KR1019950700069A patent/KR950702417A/ko not_active Withdrawn
- 1993-05-26 CA CA002136324A patent/CA2136324A1/en not_active Abandoned
- 1993-05-26 JP JP6503294A patent/JPH07508985A/ja not_active Withdrawn
- 1993-05-26 WO PCT/US1993/004850 patent/WO1994001110A1/en not_active Application Discontinuation
- 1993-05-26 AU AU43865/93A patent/AU666740B2/en not_active Expired - Fee Related
- 1993-05-26 EP EP93914058A patent/EP0648119A1/en not_active Withdrawn
- 1993-06-08 TW TW082104539A patent/TW260608B/zh active
- 1993-06-23 MX MX9303764A patent/MX9303764A/es unknown
- 1993-07-02 IL IL106220A patent/IL106220A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07508985A (ja) | 1995-10-05 |
| AU4386593A (en) | 1994-01-31 |
| AU666740B2 (en) | 1996-02-22 |
| TW260608B (enrdf_load_stackoverflow) | 1995-10-21 |
| WO1994001110A1 (en) | 1994-01-20 |
| IL106220A0 (en) | 1993-11-15 |
| KR950702417A (ko) | 1995-07-29 |
| EP0648119A1 (en) | 1995-04-19 |
| MX9303764A (es) | 1994-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |