CA2132791A1 - Azole compounds, their production and use - Google Patents

Azole compounds, their production and use

Info

Publication number
CA2132791A1
CA2132791A1 CA002132791A CA2132791A CA2132791A1 CA 2132791 A1 CA2132791 A1 CA 2132791A1 CA 002132791 A CA002132791 A CA 002132791A CA 2132791 A CA2132791 A CA 2132791A CA 2132791 A1 CA2132791 A1 CA 2132791A1
Authority
CA
Canada
Prior art keywords
group
compound
phenyl
formula
difluorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002132791A
Other languages
English (en)
French (fr)
Inventor
Katsumi Itoh
Kenji Okonogi
Akihiro Tasaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of CA2132791A1 publication Critical patent/CA2132791A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CA002132791A 1993-09-24 1994-09-23 Azole compounds, their production and use Abandoned CA2132791A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP23834093 1993-09-24
JP238340/1993 1993-09-24
JP190766/1994 1994-08-12
JP19076694 1994-08-12

Publications (1)

Publication Number Publication Date
CA2132791A1 true CA2132791A1 (en) 1995-03-25

Family

ID=26506298

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002132791A Abandoned CA2132791A1 (en) 1993-09-24 1994-09-23 Azole compounds, their production and use

Country Status (18)

Country Link
US (2) US5545652A (en, 2012)
EP (1) EP0657449B1 (en, 2012)
KR (1) KR950008508A (en, 2012)
CN (1) CN1106390A (en, 2012)
AT (1) ATE164844T1 (en, 2012)
AU (1) AU678278B2 (en, 2012)
CA (1) CA2132791A1 (en, 2012)
DE (2) DE69409473D1 (en, 2012)
FI (1) FI944417L (en, 2012)
HU (1) HU219212B (en, 2012)
MX (1) MX198902B (en, 2012)
MY (1) MY111559A (en, 2012)
NO (1) NO307785B1 (en, 2012)
NZ (1) NZ264519A (en, 2012)
PH (1) PH31217A (en, 2012)
RU (1) RU2131417C1 (en, 2012)
SG (1) SG52593A1 (en, 2012)
TW (1) TW297813B (en, 2012)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997006149A1 (de) * 1995-08-10 1997-02-20 Arzneimittelwerk Dresden Gmbh Neue, antikonvulsiv wirkende imidazolin-2,4-dione, die in 1-stellung einen orthosubstituierten ar(alk)yl-rest enthalten, und verfahren zu deren herstellung
US5677464A (en) * 1994-05-31 1997-10-14 Takeda Chemical Industries, Ltd. Production of optically active triazole compounds and their intermediates

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
WO1996025410A1 (en) * 1995-02-17 1996-08-22 Takeda Chemical Industries, Ltd. Azole compounds, their production and use
TW318841B (en, 2012) 1995-02-17 1997-11-01 Takeda Pharm Industry Co Ltd
US6153616A (en) * 1997-01-17 2000-11-28 Synphar Laboratories, Inc. Triazoles as therapeutic agents for fungal infections
RU2189982C2 (ru) * 1997-03-31 2002-09-27 Такеда Кемикал Индастриз, Лтд. Азольные соединения, способ их получения, противогрибковая фармацевтическая композиция и способ лечения грибковой инфекции
US6583164B1 (en) 1998-09-29 2003-06-24 Takeda Chemical Industries, Ltd. Antimycotic drug composition
US6238683B1 (en) 1998-12-04 2001-05-29 Johnson & Johnson Consumer Companies, Inc. Anhydrous topical skin preparations
US7179475B1 (en) * 1998-12-04 2007-02-20 Johnson & Johnson Consumer Companies, Inc. Anhydrous topical skin preparations
US6391903B1 (en) * 1999-09-09 2002-05-21 Sankyo Company, Limited Triazole derivatives having antifungal activity
FR2814073B1 (fr) * 2000-09-21 2005-06-24 Yang Ji Chemical Company Ltd Composition pharmaceutique antifongique et/ou antiparasitaire et nouveaux derives de l'indole a titre de principes actifs d'une telle composition
HUP0303249A3 (en) * 2001-02-22 2007-03-28 Sankyo Co Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them
IN192526B (en, 2012) * 2001-09-25 2004-04-24 Ranbaxy Lab
US7028055B2 (en) * 2002-03-22 2006-04-11 Sun Microsystems, Inc. Method and apparatus for improving transaction specification by marking application states
US6884892B2 (en) * 2002-06-20 2005-04-26 Sumitomo Chemical Company, Limited Production methods of epoxytriazole derivative and intermediate therefor
KR100666923B1 (ko) * 2004-07-13 2007-01-10 주식회사 두원공조 자동차용 공냉식 오일쿨러
IN2014MN01560A (en, 2012) * 2006-08-07 2015-05-08 Palau Pharma Sa
KR100909953B1 (ko) * 2007-06-15 2009-07-31 한국화학연구원 항진균 활성을 갖는 트라이아졸 유도체, 이의 제조방법 및이를 함유하는 약학 조성물
MX2013008777A (es) * 2011-01-30 2013-09-06 Meiji Seika Pharma Co Ltd Agente antifungico topico.
CN106032385B (zh) * 2015-03-18 2018-09-11 中国科学院上海药物研究所 三氮唑类化合物、其药物组合物、制备方法和用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU187399B (en) * 1980-12-24 1985-12-28 Sumitomo Chemical Co Process for preparing imidazolyl-propanol derivatives
US4753957A (en) * 1981-09-28 1988-06-28 Rohm And Haas Company Substituted 2,4-imidazolidinediones and fungicidal compositions
GB8306351D0 (en) * 1983-03-08 1983-04-13 Ici Plc Azole fungicides
DK159205C (da) * 1983-03-16 1991-03-04 Pfizer Bis(triazol)alkanol-forbindelser, anvendelse af disse, farmaceutiske praeparater og landbrugsfungicider indeholdende disse og fremgangsmaade til behandling af planter eller froe, som har en svampeinfektion
GB8412750D0 (en) * 1984-05-18 1984-06-27 Ici Plc Heterocyclic compounds
GB8729083D0 (en) * 1987-12-12 1988-01-27 Pfizer Ltd Triazole antifungal agents
HUT53889A (en) * 1988-03-04 1990-12-28 Sankyo Co. Ltd.,Jp Fungicides comprising triazole derivatives as active ingredient and process for producing the active ingredient
EP0548553A1 (en) * 1991-11-25 1993-06-30 Takeda Chemical Industries, Ltd. Optically active azole compounds, their production and use
TW218017B (en, 2012) * 1992-04-28 1993-12-21 Takeda Pharm Industry Co Ltd
US5677464A (en) * 1994-05-31 1997-10-14 Takeda Chemical Industries, Ltd. Production of optically active triazole compounds and their intermediates

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677464A (en) * 1994-05-31 1997-10-14 Takeda Chemical Industries, Ltd. Production of optically active triazole compounds and their intermediates
WO1997006149A1 (de) * 1995-08-10 1997-02-20 Arzneimittelwerk Dresden Gmbh Neue, antikonvulsiv wirkende imidazolin-2,4-dione, die in 1-stellung einen orthosubstituierten ar(alk)yl-rest enthalten, und verfahren zu deren herstellung

Also Published As

Publication number Publication date
NO943510D0 (no) 1994-09-21
MX198902B (en) 2000-10-03
FI944417A7 (fi) 1995-03-25
TW297813B (en, 2012) 1997-02-11
DE69409473T2 (de) 1998-07-30
ATE164844T1 (de) 1998-04-15
NO307785B1 (no) 2000-05-29
AU7299694A (en) 1995-04-06
KR950008508A (ko) 1995-04-17
CN1106390A (zh) 1995-08-09
NO943510L (no) 1995-03-27
FI944417A0 (fi) 1994-09-23
NZ264519A (en) 1995-09-26
US5792780A (en) 1998-08-11
EP0657449B1 (en) 1998-04-08
DE69409473T4 (de) 1999-02-25
RU2131417C1 (ru) 1999-06-10
FI944417L (fi) 1995-03-25
HU9402746D0 (en) 1994-12-28
US5545652A (en) 1996-08-13
HUT71333A (en) 1995-11-28
AU678278B2 (en) 1997-05-22
RU94034117A (ru) 1996-08-10
EP0657449A1 (en) 1995-06-14
PH31217A (en) 1998-05-05
MY111559A (en) 2000-08-30
SG52593A1 (en) 1998-09-28
DE69409473D1 (de) 1998-05-14
HU219212B (en) 2001-03-28

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued