CA2118920A1 - Benzo-isoquinoline derivatives and analogs and their use in therapeutics - Google Patents

Benzo-isoquinoline derivatives and analogs and their use in therapeutics

Info

Publication number
CA2118920A1
CA2118920A1 CA002118920A CA2118920A CA2118920A1 CA 2118920 A1 CA2118920 A1 CA 2118920A1 CA 002118920 A CA002118920 A CA 002118920A CA 2118920 A CA2118920 A CA 2118920A CA 2118920 A1 CA2118920 A1 CA 2118920A1
Authority
CA
Canada
Prior art keywords
compound
trans
chloro
dihydro
octahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002118920A
Other languages
English (en)
French (fr)
Inventor
Arthur G. Romero
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2118920A1 publication Critical patent/CA2118920A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
CA002118920A 1991-10-24 1992-09-03 Benzo-isoquinoline derivatives and analogs and their use in therapeutics Abandoned CA2118920A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US78225391A 1991-10-24 1991-10-24
US782,253 1991-10-24
US79545691A 1991-11-22 1991-11-22
US795,456 1991-11-22
PCT/US1992/007314 WO1993008166A1 (en) 1991-10-24 1992-09-03 Benzo-isoquinoline derivatives and analogs and their use in therapeutics

Publications (1)

Publication Number Publication Date
CA2118920A1 true CA2118920A1 (en) 1993-04-29

Family

ID=27119973

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002118920A Abandoned CA2118920A1 (en) 1991-10-24 1992-09-03 Benzo-isoquinoline derivatives and analogs and their use in therapeutics

Country Status (6)

Country Link
JP (1) JPH07500333A (es)
AU (1) AU2559392A (es)
CA (1) CA2118920A1 (es)
MX (1) MX9205973A (es)
TW (1) TW238309B (es)
WO (1) WO1993008166A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512566A (en) * 1993-10-25 1996-04-30 Ortho Pharmaceutical Corporation Tricyclic compounds having affinity for the 5-HT1A receptor
JP4578580B2 (ja) * 1997-04-07 2010-11-10 ジョージタウン ユニヴァーシティー コカインの類似化合物
TW200924752A (en) * 2007-09-17 2009-06-16 Organon Nv Tricyclic heterocyclic derivatives
US8546377B2 (en) 2009-04-23 2013-10-01 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US8518933B2 (en) 2009-04-23 2013-08-27 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH630902A5 (en) * 1977-01-24 1982-07-15 Sandoz Ag Process for preparing novel derivatives of 1,2,3,4,4a,10b-hexahydrobenzo(f)isoquinoline.
US4341786A (en) * 1981-03-02 1982-07-27 Smithkline Corporation Pharmaceutical compositions and method of producing central alpha1 agonist activity utilizing octahydrobenzo[f]quinoline compounds
PT77267B (en) * 1982-09-07 1986-03-21 Lilly Co Eli Improved process for preparing novel octahydrobenz <f> isoquinolines or compounds relating thereto
WO1990006927A1 (en) * 1988-12-15 1990-06-28 Abbott Laboratories 5-ht selective agents
US5049564A (en) * 1989-11-17 1991-09-17 Abbott Laboratories 5-HT selective agents
GB8917333D0 (en) * 1989-07-28 1989-09-13 Merck Sharp & Dohme Therapeutic agents
GB9014061D0 (en) * 1990-06-25 1990-08-15 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
TW238309B (es) 1995-01-11
WO1993008166A1 (en) 1993-04-29
JPH07500333A (ja) 1995-01-12
AU2559392A (en) 1993-05-21
MX9205973A (es) 1993-05-01

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Legal Events

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