CA2113547A1 - Derives puriniques - Google Patents

Derives puriniques

Info

Publication number
CA2113547A1
CA2113547A1 CA002113547A CA2113547A CA2113547A1 CA 2113547 A1 CA2113547 A1 CA 2113547A1 CA 002113547 A CA002113547 A CA 002113547A CA 2113547 A CA2113547 A CA 2113547A CA 2113547 A1 CA2113547 A1 CA 2113547A1
Authority
CA
Canada
Prior art keywords
adenosine
chloro
propyl
phenoxy
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002113547A
Other languages
English (en)
Inventor
Lars J. S. Knutsen
Jesper Lau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2113547A1 publication Critical patent/CA2113547A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA002113547A 1992-05-14 1993-05-12 Derives puriniques Abandoned CA2113547A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK92626A DK62692D0 (fr) 1992-05-14 1992-05-14
DK0626/92 1992-05-14

Publications (1)

Publication Number Publication Date
CA2113547A1 true CA2113547A1 (fr) 1993-11-25

Family

ID=8095717

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002113547A Abandoned CA2113547A1 (fr) 1992-05-14 1993-05-12 Derives puriniques

Country Status (9)

Country Link
EP (1) EP0603348A1 (fr)
JP (1) JPH06508855A (fr)
AU (1) AU671995B2 (fr)
CA (1) CA2113547A1 (fr)
DK (1) DK62692D0 (fr)
FI (1) FI940167A (fr)
IL (1) IL105673A (fr)
NZ (1) NZ252110A (fr)
WO (1) WO1993023418A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK155292D0 (da) * 1992-12-23 1992-12-23 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
US5589467A (en) * 1993-09-17 1996-12-31 Novo Nordisk A/S 2,5',N6-trisubstituted adenosine derivatives
BR9507683A (pt) * 1994-05-10 1997-09-23 Sandoz Ag Derivados de adenosina
EP0704215A3 (fr) * 1994-06-02 1998-04-01 Takeda Chemical Industries, Ltd. Inhibiteur de l'aumentation de la perméabilité vasculaire
GB9421133D0 (en) * 1994-10-20 1994-12-07 Glaxo Group Ltd Medicaments
US6110902A (en) * 1997-06-23 2000-08-29 Moehler; Hanns Method for the inhibition of neuronal activity leading to a focal epileptic seizure by local delivery of adenosine
US6803457B1 (en) 1999-09-30 2004-10-12 Pfizer, Inc. Compounds for the treatment of ischemia
CO5180581A1 (es) * 1999-09-30 2002-07-30 Pfizer Prod Inc Compuestos para el tratamiento de la isquemia ciones farmaceuticas que los contienen para el tratamiento de la isquemia
AU2001260076A1 (en) * 2000-05-15 2001-11-26 Novo-Nordisk A/S Compounds for treating disorders where a decreased level of plasma ffa is desired
US7414036B2 (en) 2002-01-25 2008-08-19 Muscagen Limited Compounds useful as A3 adenosine receptor agonists
US20100048501A1 (en) 2006-03-21 2010-02-25 Heinrich-Heine-Universitat Dusseldorf Phosphorylated A2A Receptor Agonists
CZ2009298A3 (cs) * 2009-05-14 2010-11-24 Univerzita Palackého v Olomouci Substituované 6-benzylaminopurin ribosidy, jejich použití a farmaceutický prípravek tyto slouceniny obsahující
AU2011203897B2 (en) 2010-01-11 2016-11-17 Inotek Pharmaceuticals Corporation Combination, kit and method of reducing intraocular pressure
US8501708B2 (en) * 2010-03-26 2013-08-06 Inotek Pharmaceuticals Corporation Adenosine compounds and their use thereof
US8476247B2 (en) 2010-03-26 2013-07-02 Inotek Pharmaceuticals Corporation Method of reducing intraocular pressure in humans
LT2807178T (lt) 2012-01-26 2017-08-25 Inotek Pharmaceuticals Corporation (2r,3s,4r,5r)-5-(6-(ciklopentilamino)-9h-purin-9-il)-3,4-dihidroksitetrahidrofuran-2-il) } metilnitrato bevandeniai polimorfai ir jų gavimo būdai
WO2014152723A1 (fr) 2013-03-15 2014-09-25 Inotek Pharmaceuticals Corporation Formulations ophtalmiques
JP2015172077A (ja) * 2015-06-24 2015-10-01 中国医学科学院葯物研究所 Ｎ６−置換アデノシン誘導体とｎ６−置換アデニン誘導体の鎮静、催眠、抗うつ、抗痙攣、抗てんかん、抗パーキンソン病と認知証予防・治療の用途
GB2582361A (en) * 2019-03-21 2020-09-23 Univ Warwick Adenosine receptor agonists

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL128629C (fr) * 1966-05-07
DE1670077C3 (de) * 1966-05-07 1975-04-24 Boehringer Mannheim Gmbh, 6800 Mannheim Adenosin-Derivate und Verfahren zu ihrer Herstellung
NL6717061A (fr) * 1966-12-21 1968-06-24
DE2052596A1 (de) * 1970-10-27 1972-05-04 Boehringer Mannheim Gmbh, 6800 Mannheim Neuartige Verwendung von N(6)-substituierten Adenosin-Derivaten
DE3406533A1 (de) * 1984-02-23 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten
EP0300145A3 (fr) * 1984-04-18 1989-08-30 Whitby Research Incorporated Dérivés d'adénosine N-6-phényle substitué comme vaso-dilatateurs cardiaques
US4791103A (en) * 1985-02-08 1988-12-13 Warner-Lambert Company 2,N6 -disubstituted adenosines, derivatives and methods of use
JPH0696534B2 (ja) * 1986-04-25 1994-11-30 ヘキストジヤパン株式会社 抗痴呆剤
GB8729994D0 (en) * 1987-12-23 1988-02-03 Glaxo Group Ltd Chemical compounds
HUT61567A (en) * 1990-12-07 1993-01-28 Sandoz Ag Process for producing new pharmaceutical compositions comprising 2'-o-alkyladenosine derivatives and for producing 6-cyclohexyl-2'-o-methyladenosinehydrate
DK62592D0 (fr) * 1992-05-14 1992-05-14 Novo Nordisk As

Also Published As

Publication number Publication date
AU671995B2 (en) 1996-09-19
JPH06508855A (ja) 1994-10-06
AU4061293A (en) 1993-12-13
FI940167A (fi) 1994-03-03
DK62692D0 (fr) 1992-05-14
FI940167A0 (fi) 1994-01-13
EP0603348A1 (fr) 1994-06-29
IL105673A (en) 1998-01-04
WO1993023418A1 (fr) 1993-11-25
NZ252110A (en) 1996-07-26
IL105673A0 (en) 1993-09-22

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Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 19990512