CA2095518A1 - Specific inhibition of dihydrofolate reductase and compounds therefor - Google Patents

Specific inhibition of dihydrofolate reductase and compounds therefor

Info

Publication number
CA2095518A1
CA2095518A1 CA002095518A CA2095518A CA2095518A1 CA 2095518 A1 CA2095518 A1 CA 2095518A1 CA 002095518 A CA002095518 A CA 002095518A CA 2095518 A CA2095518 A CA 2095518A CA 2095518 A1 CA2095518 A1 CA 2095518A1
Authority
CA
Canada
Prior art keywords
diamino
pyrimidine
benzyl
methoxy
methoxybenzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002095518A
Other languages
English (en)
French (fr)
Inventor
Jeffrey M. Blaney
Charles K. Marlow
Ivan Kompis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
PROTOS Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PROTOS Corp filed Critical PROTOS Corp
Publication of CA2095518A1 publication Critical patent/CA2095518A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002095518A 1990-11-14 1991-11-14 Specific inhibition of dihydrofolate reductase and compounds therefor Abandoned CA2095518A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US61361990A 1990-11-14 1990-11-14
US613,619 1990-11-14
US73069191A 1991-07-16 1991-07-16
US730,691 1991-07-16

Publications (1)

Publication Number Publication Date
CA2095518A1 true CA2095518A1 (en) 1992-05-15

Family

ID=27087063

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002095518A Abandoned CA2095518A1 (en) 1990-11-14 1991-11-14 Specific inhibition of dihydrofolate reductase and compounds therefor

Country Status (7)

Country Link
EP (1) EP0639075A1 (de)
JP (1) JPH07509215A (de)
AU (1) AU657348B2 (de)
CA (1) CA2095518A1 (de)
IE (1) IE913974A1 (de)
PT (1) PT99514B (de)
WO (1) WO1992008461A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721242A (en) * 1993-06-17 1998-02-24 Hoffmann-La Roche Inc. Antibiotic combination
KR100417508B1 (ko) * 1994-11-24 2004-03-18 바실리어 파마슈티카 아게 신규한벤질피리미딘
TW438796B (en) * 1996-05-15 2001-06-07 Hoffmann La Roche 2,4-diaminopyrimidine derivatives, the manufacture process thereof, and the antibiotically-active pharmaceutical composition containing the same
AU6203098A (en) * 1997-02-24 1998-09-18 Barry J. Barclay Synergistically acting anti-fungal agents that are inhibitors of folate metabolism, especially methotrexate and sulfamethoxazole
HUP0201333A3 (en) 1999-05-24 2004-11-29 Sankyo Company Ltd Chuo Ku Medicinal compositions containing anti-fas antibody
US8853228B2 (en) * 2007-06-04 2014-10-07 University Of Connecticut Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2658897A (en) * 1951-06-27 1953-11-10 Burroughs Wellcome Co 2, 4-diamino-5-benzyl pyrimidines
FR1090394A (fr) * 1953-03-11 1955-03-30 Wellcome Found Dérivés de pyrimidine et leur fabrication
US2852450A (en) * 1954-06-10 1958-09-16 Donnelley & Sons Co Method of copper plating
FR1292920A (fr) * 1959-04-18 1962-05-11 Wellcome Found Dérivés de la pyrimidine et leur préparation
GB1142654A (en) * 1965-10-28 1969-02-12 Wellcome Found Cyano-acetals and their use in benzylpyrimidine synthesis
FR94837E (fr) * 1966-02-19 1969-11-28 Wellcome Found Procédé de préparation de dérivés de la pyrimidine.
GB1181657A (en) * 1966-03-31 1970-02-18 Ici Ltd Pyrimidine Derivatives and Compositions Containing them
BE793253A (fr) * 1971-12-23 1973-04-16 Lepetit Spa Nouvelles compositions bactericides et leur utilisation
CH591457A5 (de) * 1973-11-08 1977-09-15 Hoffmann La Roche
DE2617967C3 (de) * 1976-04-24 1978-11-02 Nordmark-Werke Gmbh, 2000 Hamburg Verfahren zur Herstellung von 2,4-Diamino-5-benzylpyrimidinen
IE45427B1 (en) * 1976-07-09 1982-08-25 American Home Prod Pyrrold 3,2if quinazoline-1,3-diamine and related compounds
LU77268A1 (de) * 1977-05-05 1979-01-18
LU77269A1 (de) * 1977-05-05 1979-01-18
GR71725B (de) * 1977-11-10 1983-06-22 Hoffmann La Roche
US4233445A (en) * 1979-07-05 1980-11-11 American Home Products Corporation 7-(Substituted)-7H-pyrrolo[3.2-F]-quinazoline-1,3-diamines
US4258045A (en) * 1979-11-30 1981-03-24 Merck & Co., Inc. Inhibitor of dihydrofolate reductase
OA07362A (fr) * 1980-10-27 1984-06-30 May & Baker Ltd Dérivés de la pyrimidine, leur procédé de préparation et les compositions les contenant.
EP0054756B1 (de) * 1980-11-27 1986-07-23 The Wellcome Foundation Limited Antibakterielle Benzylpyrimidine
US4451466A (en) * 1982-07-02 1984-05-29 Shell Oil Company Use of pyrroloquinazolinediamines as pesticides
CA1244028A (en) * 1983-04-14 1988-11-01 Hans Maag Pyrimidine derivatives
EP0139613A1 (de) * 1983-08-29 1985-05-02 Ciba-Geigy Ag N-(2-Nitrophenyl)-4-aminopyrimidin-Derivate, deren Herstellung und Verwendung
US4501890A (en) * 1983-09-26 1985-02-26 Eli Lilly And Company Trans-(±)-2,4,6-substituted-5,5a,6,7,8,9,9a,10-octahydro-pyrimido[4,5-g]quinolines
DE3417264A1 (de) * 1984-05-10 1985-11-14 Bayer Ag, 5090 Leverkusen Neue 2,4-diamino-6-halogen-5-alkylthio-pyrimidine
DE3701277A1 (de) * 1987-01-17 1988-07-28 Boehringer Mannheim Gmbh Neue tricyclische benzimidazole, verfahren zu ihrer herstellung und verwendung als arzneimittel
US4996198A (en) * 1988-07-11 1991-02-26 Hoffmann-La Roche Inc. Anticoccidial composition

Also Published As

Publication number Publication date
WO1992008461A1 (en) 1992-05-29
PT99514A (pt) 1992-10-30
JPH07509215A (ja) 1995-10-12
AU2202792A (en) 1994-04-28
AU657348B2 (en) 1995-03-09
IE913974A1 (en) 1992-05-20
EP0639075A1 (de) 1995-02-22
PT99514B (pt) 1999-04-30
EP0639075A4 (de) 1993-09-29

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Legal Events

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