CA2095224A1 - Heterocyclic compounds as antagonists of excitatory amino acid receptors, processes for their preparation and their use - Google Patents

Heterocyclic compounds as antagonists of excitatory amino acid receptors, processes for their preparation and their use

Info

Publication number
CA2095224A1
CA2095224A1 CA002095224A CA2095224A CA2095224A1 CA 2095224 A1 CA2095224 A1 CA 2095224A1 CA 002095224 A CA002095224 A CA 002095224A CA 2095224 A CA2095224 A CA 2095224A CA 2095224 A1 CA2095224 A1 CA 2095224A1
Authority
CA
Canada
Prior art keywords
group
alkyl
compounds
methylene
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002095224A
Other languages
English (en)
French (fr)
Inventor
Alf Claesson
Britt-Marie Swahn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2095224A1 publication Critical patent/CA2095224A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
CA002095224A 1990-11-15 1991-11-07 Heterocyclic compounds as antagonists of excitatory amino acid receptors, processes for their preparation and their use Abandoned CA2095224A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9003652A SE9003652D0 (sv) 1990-11-15 1990-11-15 New heterocyclic compounds
SE9003652-6 1990-11-15

Publications (1)

Publication Number Publication Date
CA2095224A1 true CA2095224A1 (en) 1992-05-16

Family

ID=20380925

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002095224A Abandoned CA2095224A1 (en) 1990-11-15 1991-11-07 Heterocyclic compounds as antagonists of excitatory amino acid receptors, processes for their preparation and their use

Country Status (17)

Country Link
EP (1) EP0557375A1 (sv)
JP (1) JPH06502421A (sv)
CN (1) CN1061595A (sv)
AU (1) AU652399B2 (sv)
CA (1) CA2095224A1 (sv)
CZ (1) CZ80993A3 (sv)
FI (1) FI932206A (sv)
HU (1) HU9301417D0 (sv)
IE (1) IE913922A1 (sv)
IS (1) IS3782A7 (sv)
LT (1) LTIP1718A (sv)
MX (1) MX9101979A (sv)
NO (1) NO931679L (sv)
PT (1) PT99515A (sv)
SE (1) SE9003652D0 (sv)
SK (1) SK46993A3 (sv)
WO (1) WO1992008724A1 (sv)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194430A (en) * 1990-05-17 1993-03-16 Merrell Dow Pharmaceuticals Inc. Heterocyclic-nmda antagonists
TW281670B (sv) * 1993-09-02 1996-07-21 Hoffmann La Roche
US5491241A (en) * 1993-10-18 1996-02-13 Eli Lilly And Company Bicyclic intermediates for excitatory amino acid receptor antagonists
US10508083B2 (en) 2016-02-04 2019-12-17 Takeda Pharmaceutical Company Limited Substituted piperidine compound and use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1248531A (en) * 1984-04-17 1989-01-10 Jeffrey C. Watkins 4-substituted piperazine-2-carboxylic acids
JPS612519A (ja) * 1984-04-24 1986-01-08 Aron Kasei Co Ltd 射出成形法
US4906621A (en) * 1985-05-24 1990-03-06 Ciba-Geigy Corporation Certain 2-carboxypiperidyl-alkylene phosphonic acids and esters thereof useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade
US4740346A (en) * 1986-02-26 1988-04-26 The Budd Company Perimeter resin feeding of composite structures
JPS63112129A (ja) * 1986-10-30 1988-05-17 Toyoda Gosei Co Ltd 多色樹脂成形用金型
IL84492A0 (en) * 1986-11-21 1988-04-29 Ciba Geigy Ag Unsaturated phosphonic acids and derivatives

Also Published As

Publication number Publication date
CZ80993A3 (en) 1994-02-16
NO931679D0 (no) 1993-05-07
IS3782A7 (is) 1992-05-16
EP0557375A1 (en) 1993-09-01
CN1061595A (zh) 1992-06-03
AU652399B2 (en) 1994-08-25
SK46993A3 (en) 1993-10-06
HU9301417D0 (en) 1993-09-28
FI932206A0 (fi) 1993-05-14
JPH06502421A (ja) 1994-03-17
IE913922A1 (en) 1992-05-20
FI932206A (fi) 1993-05-14
PT99515A (pt) 1992-09-30
SE9003652D0 (sv) 1990-11-15
MX9101979A (es) 1992-07-08
NO931679L (no) 1993-05-07
LTIP1718A (en) 1995-07-25
WO1992008724A1 (en) 1992-05-29
AU8939191A (en) 1992-06-11

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Legal Events

Date Code Title Description
FZDE Discontinued