CA2093513A1 - Methode et compositions visant a freiner le rejet des allogreffes chez les mammiferes - Google Patents
Methode et compositions visant a freiner le rejet des allogreffes chez les mammiferesInfo
- Publication number
- CA2093513A1 CA2093513A1 CA2093513A CA2093513A CA2093513A1 CA 2093513 A1 CA2093513 A1 CA 2093513A1 CA 2093513 A CA2093513 A CA 2093513A CA 2093513 A CA2093513 A CA 2093513A CA 2093513 A1 CA2093513 A1 CA 2093513A1
- Authority
- CA
- Canada
- Prior art keywords
- methods
- mammals
- allograft
- compositions
- allograft rejection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000124008 Mammalia Species 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000000284 extract Substances 0.000 abstract 2
- 210000004698 lymphocyte Anatomy 0.000 abstract 2
- 230000003393 splenic effect Effects 0.000 abstract 2
- 239000000443 aerosol Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Transplantation (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
L'invention décrit des procédés servant à supprimer le rejet d'une allogreffe chez des mammifères comprenant l'administration audit mammifère, ayant subi ou étant sur le point de subir l'implantation chirurgicale d'une allogreffe, d'un agent sélectionné à partir du groupe constitué par le tissu splénique d'un donneur d'allogreffe, d'extraits spléniques, de lymphocytes cultivés à partir d'un donneur d'allogreffe, des extraits desdits lymphocytes cultivés, des antigènes MHC (complexe majeur d'histocompatibilité), des fragments suppressifs de rejet de transplantation et des analogues d'antigènes MHC sous forme orale ou d'aérosol. L'invention décrit également des formulations et des formes de dosage pharmaceutiques s'appliquant auxdits procédés.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60782690A | 1990-10-31 | 1990-10-31 | |
US607,826 | 1990-10-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2093513A1 true CA2093513A1 (fr) | 1992-05-01 |
CA2093513C CA2093513C (fr) | 1999-03-23 |
Family
ID=24433875
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002093513A Expired - Fee Related CA2093513C (fr) | 1990-10-31 | 1991-10-31 | Methode et compositions visant a freiner le rejet des allogreffes chez les mammiferes |
Country Status (11)
Country | Link |
---|---|
US (2) | US5681556A (fr) |
EP (1) | EP0555413A4 (fr) |
JP (1) | JP2547162B2 (fr) |
KR (1) | KR0161235B1 (fr) |
AU (1) | AU662500B2 (fr) |
BR (1) | BR9107055A (fr) |
CA (1) | CA2093513C (fr) |
HU (1) | HUT63957A (fr) |
IL (1) | IL99864A (fr) |
NO (1) | NO931536D0 (fr) |
WO (1) | WO1992007581A1 (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5571500A (en) * | 1987-06-24 | 1996-11-05 | Autoimmune, Inc. | Treatment of autoimmune diseases through administration by inhalation of autoantigens |
US5641474A (en) * | 1987-06-24 | 1997-06-24 | Autoimmune, Inc. | Prevention of autoimmune diseases by aerosol administration of autoantigens |
US5645820A (en) * | 1987-06-24 | 1997-07-08 | Autoimmune, Inc. | Treatment of autoimmune diseases by aerosol administration of autoantigens |
US5571499A (en) * | 1987-06-24 | 1996-11-05 | Autoimmune, Inc. | Treatment of autoimmune diseases by aerosol administration of autoantigens |
IL99699A (en) | 1990-10-10 | 2002-04-21 | Autoimmune Inc | Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes |
PT503648E (pt) * | 1991-03-12 | 2000-10-31 | Biogen Inc | Dominio do antigenio 3 associado a funcao linfocitica de ligacao as cd2 |
MX9203138A (es) * | 1991-03-12 | 1992-09-01 | Biogen Inc | Dominio de enlace cd2-de antigeno 3 (lfa-3) asociado con funcion linfositos. |
US6764681B2 (en) | 1991-10-07 | 2004-07-20 | Biogen, Inc. | Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction |
GB9319429D0 (en) * | 1993-09-21 | 1993-11-03 | London Health Ass | Methods and products for controlling immune responses in mammals |
WO1995020661A1 (fr) * | 1994-01-27 | 1995-08-03 | Bresatec Ltd. | Procedes et substances destines a la prise en charge du rejet hyperaigu suite a une heterogreffe chez l'homme |
US5849991A (en) | 1994-01-27 | 1998-12-15 | Bresatch Limited | Mice homozygous for an inactivated α 1,3-galactosyl transferase gene |
JPH08239324A (ja) * | 1995-03-03 | 1996-09-17 | Fusanori Hamashima | 免疫抑制剤 |
US20020155117A1 (en) * | 1996-04-04 | 2002-10-24 | Nicole Suciu-Foca | Method for detecting organ allograft rejection and uses thereof |
EP2301567A1 (fr) * | 1997-02-28 | 2011-03-30 | Enzo Therapeutics, Inc. | Réglulation immunitaire négative sélective (SIDR) pour transplantation |
US7097845B2 (en) | 1997-04-23 | 2006-08-29 | Jacob Sten Petersen | Combinations of antigen and mucosal binding component for inducing specific immunological tolerance |
US6685936B2 (en) * | 1999-10-12 | 2004-02-03 | Osiris Therapeutics, Inc. | Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation |
US20020012667A1 (en) * | 2000-05-16 | 2002-01-31 | Mcmichael John | Method for preventing allograft rejection |
DE60129552T2 (de) | 2000-05-24 | 2008-04-17 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | E-selectin zur behandlung oder vorbeugung von schlaganfall |
US20030170258A1 (en) * | 2001-05-09 | 2003-09-11 | Enzo Therapeutics, Inc. | Novel processes implementing selective immune down regulation (SIDR) |
WO2003009740A2 (fr) | 2001-07-24 | 2003-02-06 | Biogen Idec Ma Inc. | Methodes de traitement ou de prevention de troubles sclereux par l'usage d'agents se liant a cd2 |
EP1446113A4 (fr) * | 2001-10-25 | 2006-12-06 | Atherogenics Inc | Composes et methodes de traitement d'un rejet de greffe |
EP1750747A1 (fr) | 2004-05-07 | 2007-02-14 | Astellas US LLC | Polypeptide lfa-3 soluble destine a traiter de troubles viraux |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5899419A (ja) * | 1981-12-07 | 1983-06-13 | Green Cross Corp:The | 免疫抑制剤 |
JPS59116224A (ja) * | 1982-10-01 | 1984-07-05 | デイミトリ・アダモポ−ロス | 免疫反応を抑制する組成物およびその製法 |
US4635627A (en) * | 1984-09-13 | 1987-01-13 | Riker Laboratories, Inc. | Apparatus and method |
US5130297A (en) * | 1988-06-23 | 1992-07-14 | Anergen, Inc. | Conjugates useful in ameliorating autoimmunity MHC-II-peptide |
US5011037A (en) * | 1989-11-30 | 1991-04-30 | Adolph Coors Company | Container end member |
RU2054180C1 (ru) * | 1991-08-21 | 1996-02-10 | Жирнов Олег Петрович (н/п) | Способ лечения вирусных респираторных инфекций |
-
1991
- 1991-10-27 IL IL9986491A patent/IL99864A/xx not_active IP Right Cessation
- 1991-10-31 HU HU931252A patent/HUT63957A/hu unknown
- 1991-10-31 EP EP9292902860A patent/EP0555413A4/en not_active Withdrawn
- 1991-10-31 BR BR919107055A patent/BR9107055A/pt not_active Application Discontinuation
- 1991-10-31 JP JP4500909A patent/JP2547162B2/ja not_active Expired - Lifetime
- 1991-10-31 CA CA002093513A patent/CA2093513C/fr not_active Expired - Fee Related
- 1991-10-31 KR KR1019930701248A patent/KR0161235B1/ko not_active IP Right Cessation
- 1991-10-31 WO PCT/US1991/008143 patent/WO1992007581A1/fr not_active Application Discontinuation
- 1991-10-31 AU AU89426/91A patent/AU662500B2/en not_active Ceased
-
1993
- 1993-04-27 NO NO931536A patent/NO931536D0/no not_active Application Discontinuation
- 1993-11-29 US US08/159,044 patent/US5681556A/en not_active Expired - Fee Related
-
1995
- 1995-06-05 US US08/461,661 patent/US5788968A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2547162B2 (ja) | 1996-10-23 |
NO931536L (no) | 1993-04-27 |
BR9107055A (pt) | 1993-09-21 |
AU662500B2 (en) | 1995-09-07 |
CA2093513C (fr) | 1999-03-23 |
IL99864A (en) | 2000-11-21 |
WO1992007581A1 (fr) | 1992-05-14 |
HU9301252D0 (en) | 1993-07-28 |
KR930701969A (ko) | 1993-09-08 |
NO931536D0 (no) | 1993-04-27 |
IL99864A0 (en) | 1992-08-18 |
US5788968A (en) | 1998-08-04 |
AU8942691A (en) | 1992-05-26 |
HUT63957A (en) | 1993-11-29 |
EP0555413A1 (fr) | 1993-08-18 |
US5681556A (en) | 1997-10-28 |
JPH05508663A (ja) | 1993-12-02 |
KR0161235B1 (ko) | 1998-12-01 |
EP0555413A4 (en) | 1994-12-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |