CA2088354A1 - Pancreas-Elastasis-1-Specific Antibody, a Process for Obtaining It and a Test Kit Containing Such Antibodies - Google Patents

Pancreas-Elastasis-1-Specific Antibody, a Process for Obtaining It and a Test Kit Containing Such Antibodies

Info

Publication number
CA2088354A1
CA2088354A1 CA 2088354 CA2088354A CA2088354A1 CA 2088354 A1 CA2088354 A1 CA 2088354A1 CA 2088354 CA2088354 CA 2088354 CA 2088354 A CA2088354 A CA 2088354A CA 2088354 A1 CA2088354 A1 CA 2088354A1
Authority
CA
Canada
Prior art keywords
antibodies
test kit
kit containing
obtaining
elastasis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2088354
Other languages
French (fr)
Other versions
CA2088354C (en
Inventor
Hans Scheefers
Ursula Scheefers-Borchel
Andreas Sziegoleit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SCHEBO-TECH GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2088354A1 publication Critical patent/CA2088354A1/en
Application granted granted Critical
Publication of CA2088354C publication Critical patent/CA2088354C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6448—Elastases, e.g. pancreatic elastase (3.4.21.36); leukocyte elastase (3.4.31.37)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes

Abstract

A process is described for obtaining highly specific pancreas elastase 1 antibodies which react both with bodily fluids and with stools. Such an antibody is obtainable by immunizing with an antigen having the amino acid sequence Thr-Met-vat-Ala-Gly-Gly-Asp-Ile-Arg or immunologically active partial peptides thereof. A test kit containing such antibodies is suitable for the diagnosis and course monitoring of chronic and acute pancreatitis as well as mucovisoidosis in bodily fluids and/or in stools.
CA002088354A 1990-07-28 1991-07-28 Pancreas-elastasis-1-specific antibody, a process for obtaining it and a test kit containing such antibodies Expired - Fee Related CA2088354C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE4023972 1990-07-28
DEP4023972.1 1990-07-28
DEP4107765.2 1991-03-11
DE4107765A DE4107765A1 (en) 1990-07-28 1991-03-11 PANCREAS ELASTASE-1 SPECIFIC ANTIBODY, A METHOD FOR ITS OBTAINMENT AND A TEST KIT CONTAINING SUCH ANTIBODIES
PCT/DE1991/000606 WO1992002630A1 (en) 1990-07-28 1991-07-28 Pancreas-elastasis-1-specific antibody, a process for obtaining it and a test kit containing such antibodies

Publications (2)

Publication Number Publication Date
CA2088354A1 true CA2088354A1 (en) 1992-01-29
CA2088354C CA2088354C (en) 1999-09-28

Family

ID=25895430

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002088354A Expired - Fee Related CA2088354C (en) 1990-07-28 1991-07-28 Pancreas-elastasis-1-specific antibody, a process for obtaining it and a test kit containing such antibodies

Country Status (10)

Country Link
EP (1) EP0547059B1 (en)
JP (2) JPH05508770A (en)
AT (1) ATE128734T1 (en)
AU (1) AU646476B2 (en)
CA (1) CA2088354C (en)
DE (2) DE4107765A1 (en)
DK (1) DK0547059T3 (en)
ES (1) ES2080955T3 (en)
GR (1) GR3018483T3 (en)
WO (1) WO1992002630A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0488470T3 (en) * 1990-11-26 1997-12-22 Akzo Nobel Nv Method for producing antibodies
EP0958833A1 (en) * 1998-05-20 1999-11-24 Erasmus Universiteit Rotterdam Methods and means for preventing or treating inflammation
EP1112496B1 (en) * 1998-09-08 2006-07-05 Bioserv Analytik und Medizinprodukte GmbH Diagnostic method for detecting disturbances of the pancreas
DE19923892A1 (en) 1998-09-08 2000-03-09 Privates Inst Bioserv Gmbh Diagnostic procedure for the detection of pancreatic dysfunction
GB9908458D0 (en) * 1999-04-13 1999-06-09 Queen Mary & Westfield College Enzyme
DE10157336B4 (en) * 2000-11-24 2007-07-19 Bioserv Analytik Und Medizinprodukte Gmbh Method for producing a test system and diagnostic method for detecting pancreatic function disorders
DE10101792B4 (en) * 2001-01-17 2004-03-18 Vivotec Biomedical Technologies Gmbh Procedure for the detection of pancreatic carcinoma or chronic pancreatitis and use of antibodies
JP2006226795A (en) * 2005-02-16 2006-08-31 Tokyo Univ Of Science Diagnostic marker of acute pancreatitis
CN111044723A (en) * 2018-10-12 2020-04-21 谢鲍生物科技股份公司 Novel test kit containing trypsin-1-specific antibodies and sample preparation device
WO2023100910A1 (en) * 2021-11-30 2023-06-08 株式会社Ｌｓｉメディエンス Method for measuring elastase 1 in feces

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5925183B2 (en) * 1978-07-05 1984-06-15 ダイナボット株式会社 Method for measuring elastase-1
JP2617299B2 (en) * 1986-09-17 1997-06-04 ダイナボット 株式会社 Immunoassay method for elastase 1

Also Published As

Publication number Publication date
DK0547059T3 (en) 1996-02-19
ES2080955T3 (en) 1996-02-16
ATE128734T1 (en) 1995-10-15
WO1992002630A1 (en) 1992-02-20
GR3018483T3 (en) 1996-03-31
DE4107765A1 (en) 1992-01-30
AU8100291A (en) 1992-03-02
DE59106634D1 (en) 1995-11-09
JPH05508770A (en) 1993-12-09
JPH1080272A (en) 1998-03-31
EP0547059B1 (en) 1995-10-04
EP0547059A1 (en) 1993-06-23
AU646476B2 (en) 1994-02-24
CA2088354C (en) 1999-09-28

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