WO1997039029A3 - An antigenic epitope of the a determinant of hepatitis b surface antigen and uses thereof - Google Patents

An antigenic epitope of the a determinant of hepatitis b surface antigen and uses thereof Download PDF

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Publication number
WO1997039029A3
WO1997039029A3 PCT/US1997/006732 US9706732W WO9739029A3 WO 1997039029 A3 WO1997039029 A3 WO 1997039029A3 US 9706732 W US9706732 W US 9706732W WO 9739029 A3 WO9739029 A3 WO 9739029A3
Authority
WO
WIPO (PCT)
Prior art keywords
hepatitis
surface antigen
antigenic epitope
determinant
peptide
Prior art date
Application number
PCT/US1997/006732
Other languages
French (fr)
Other versions
WO1997039029A2 (en
Inventor
Dominique P Bridon
Xiaoxing Qiu
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to JP09537434A priority Critical patent/JP2000514643A/en
Priority to EP97921323A priority patent/EP0906337A2/en
Publication of WO1997039029A2 publication Critical patent/WO1997039029A2/en
Publication of WO1997039029A3 publication Critical patent/WO1997039029A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5761—Hepatitis B
    • G01N33/5764—Hepatitis B surface antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The subject invention relates to a peptide sequence corresponding to amino acid residues (117 to 128) of hepatitis B surface antigen and uses thereof. In particular, the peptide is an antigenic epitope and may therefore be used, for example, as a diagnostic reagent or in the production of a vaccine. Furthermore, the present invention also relates to a C(K/R)TC motif present within the peptide as well as to other peptides containing this motif.
PCT/US1997/006732 1996-04-18 1997-04-18 An antigenic epitope of the a determinant of hepatitis b surface antigen and uses thereof WO1997039029A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP09537434A JP2000514643A (en) 1996-04-18 1997-04-18 Antigenic epitope of a-determinant of hepatitis B surface antigen and its use
EP97921323A EP0906337A2 (en) 1996-04-18 1997-04-18 AN ANTIGENIC EPITOPE OF THE u A /u DETERMINANT OF HEPATITIS B SURFACE ANTIGEN AND USES THEREOF

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63542896A 1996-04-18 1996-04-18
US08/635,428 1996-04-18

Publications (2)

Publication Number Publication Date
WO1997039029A2 WO1997039029A2 (en) 1997-10-23
WO1997039029A3 true WO1997039029A3 (en) 2001-06-28

Family

ID=24547753

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/006732 WO1997039029A2 (en) 1996-04-18 1997-04-18 An antigenic epitope of the a determinant of hepatitis b surface antigen and uses thereof

Country Status (4)

Country Link
EP (1) EP0906337A2 (en)
JP (1) JP2000514643A (en)
CA (1) CA2251904A1 (en)
WO (1) WO1997039029A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0919568A1 (en) 1997-12-01 1999-06-02 Sorin Diagnostics S.r.l. Escape mutant of the surface antigen of hepatitis B virus
EP1111388A1 (en) * 1999-12-23 2001-06-27 Universiteit Gent Interaction between CD14 and HBV components
MXPA06013933A (en) 2004-06-07 2007-01-26 Chiron Corp Rabbit monoclonal antibodies to hepatitis b surface antigens and methods of using the same.
JP4948783B2 (en) * 2005-05-18 2012-06-06 シスメックス株式会社 Anti-HBs monoclonal antibody
EP3308798B1 (en) * 2012-06-11 2020-09-09 Xiamen University Polypeptides and antibodies for treating hbv infection and related diseases
WO2017059878A1 (en) 2015-10-07 2017-04-13 Humabs Biomed Sa Antibodies that potently neutralize hepatitis b virus and uses thereof
CA3053591C (en) 2017-02-17 2023-03-21 Xiamen University Polypeptide carrier for presenting target polypeptide and uses thereof
JP2023527918A (en) * 2020-06-08 2023-06-30 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Anti-HBV antibody and method of use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155146A2 (en) * 1984-03-09 1985-09-18 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
JPH045300A (en) * 1990-04-20 1992-01-09 Tetsuo Nakamura Viral hepatitis type b vaccine and antibody specific to hbs antigen
WO1995016704A1 (en) * 1993-12-16 1995-06-22 Smithkline Beecham Biologicals S.A. Hepatitis b virus peptides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155146A2 (en) * 1984-03-09 1985-09-18 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
JPH045300A (en) * 1990-04-20 1992-01-09 Tetsuo Nakamura Viral hepatitis type b vaccine and antibody specific to hbs antigen
WO1995016704A1 (en) * 1993-12-16 1995-06-22 Smithkline Beecham Biologicals S.A. Hepatitis b virus peptides

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 113, no. 9, 27 August 1990, Columbus, Ohio, US; abstract no. 76023, MUNEKATA, EISUKE ET AL: "Epitope mapping in the protein of hepatitis B-virus" XP002044689 *
DATABASE WPI Section Ch Week 9208, Derwent World Patents Index; Class B04, AN 92-060743, XP002044690 *
FERNANDEZ-DE-COSSIO, MARIA E. ET AL: "Murine monoclonal antibodies specific for the HBsAg a determinant", BIOTECNOL. APL. (1995), 12(2), 89-90 CODEN: BTAPEP;ISSN: 0864-4551, 1995, XP002044687 *
H. OHNUMA ET AL.: "Synthetic Oligopeptides Bearing a Common or Subtypic Determinant of Hepatitis B Surface Antigen", JOURNAL OF IMMUNOLOGY, vol. 145, no. 7, 1 October 1990 (1990-10-01), BALTIMORE US, pages 2265 - 2271, XP002044688 *
PEPT. CHEM. (1990), VOLUME DATE 1989, 27TH, 281-4 CODEN: PECHDP;ISSN: 0388-3698, 1990 *
QIU, XIAOXING ET AL: "Identification and characterization of a C(K/R)TC motif as a common epitope present in all subtypes of hepatitis B surface antigen", J. IMMUNOL. (1996), 156(9), 3350-6 CODEN: JOIMA3;ISSN: 0022-1767, 1 May 1996 (1996-05-01), XP002044686 *

Also Published As

Publication number Publication date
CA2251904A1 (en) 1997-10-23
JP2000514643A (en) 2000-11-07
EP0906337A2 (en) 1999-04-07
WO1997039029A2 (en) 1997-10-23

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