CA2087902C - Liposome compositions of porphyrin photosensitizers - Google Patents

Liposome compositions of porphyrin photosensitizers Download PDF

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Publication number
CA2087902C
CA2087902C CA 2087902 CA2087902A CA2087902C CA 2087902 C CA2087902 C CA 2087902C CA 2087902 CA2087902 CA 2087902 CA 2087902 A CA2087902 A CA 2087902A CA 2087902 C CA2087902 C CA 2087902C
Authority
CA
Canada
Prior art keywords
porphyrin
bpd
formulation according
liposomal
liposomal formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA 2087902
Other languages
English (en)
French (fr)
Other versions
CA2087902A1 (en
Inventor
Narendra Raghunathji Desai
Bushra J. Agha
Kalidas Madhavrao Kale
James R. Lawter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bausch Health Companies Inc
Original Assignee
QLT Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by QLT Inc filed Critical QLT Inc
Publication of CA2087902A1 publication Critical patent/CA2087902A1/en
Application granted granted Critical
Publication of CA2087902C publication Critical patent/CA2087902C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Radiation-Therapy Devices (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
CA 2087902 1992-02-05 1993-01-22 Liposome compositions of porphyrin photosensitizers Expired - Lifetime CA2087902C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83254292A 1992-02-05 1992-02-05
US07/832,542 1992-02-05

Publications (2)

Publication Number Publication Date
CA2087902A1 CA2087902A1 (en) 1993-08-06
CA2087902C true CA2087902C (en) 2006-10-17

Family

ID=25261954

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2087902 Expired - Lifetime CA2087902C (en) 1992-02-05 1993-01-22 Liposome compositions of porphyrin photosensitizers

Country Status (11)

Country Link
US (1) US6074666A (es)
EP (1) EP0569113B1 (es)
JP (1) JP3020372B2 (es)
KR (1) KR970007303B1 (es)
AT (1) ATE151984T1 (es)
CA (1) CA2087902C (es)
DE (1) DE69310014T2 (es)
DK (1) DK0569113T3 (es)
ES (1) ES2100452T3 (es)
GR (1) GR3023906T3 (es)
MX (1) MX9300560A (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6890555B1 (en) * 1992-02-05 2005-05-10 Qlt, Inc. Liposome compositions of porphyrin photosensitizers
SA95160463B1 (ar) * 1994-12-22 2005-10-04 استرا أكتيبولاج مساحيق للاستنشاق
US5707608A (en) * 1995-08-02 1998-01-13 Qlt Phototherapeutics, Inc. Methods of making liposomes containing hydro-monobenzoporphyrin photosensitizer
JP2001511128A (ja) * 1997-01-28 2001-08-07 ファルマシア・アンド・アップジョン・カンパニー 水不溶性ポルフィリンの脂質錯体の凍結乾燥物
WO1999013916A2 (en) * 1997-09-18 1999-03-25 Nycomed Imaging As Methods and compositions for medical imaging
EP0911023A1 (en) * 1998-03-20 1999-04-28 Mario Luca Russo Pharmaceutical or cosmetic compositions containing photosensitizing substances
DE19852245A1 (de) * 1998-11-12 2000-05-18 Asat Ag Applied Science & Tech 5-Aminolävulinsäure-Nanoemulsion
KR100750842B1 (ko) * 1999-01-27 2007-08-22 텔리크 인코포레이티드 글루타티온 유사체를 함유하는 치료 조성물
US6608050B2 (en) 1999-07-20 2003-08-19 Pharmacia & Upjohn Company Lyophilizate of lipid complex of water insoluble porphyrins
EE200200547A (et) 2000-03-24 2004-02-16 Novartis Ag Neovaskularisatsiooni parendatud ravi
US7282215B2 (en) * 2000-05-08 2007-10-16 The University Of British Columbia Supports for photosensitizer formulations
US6984395B2 (en) * 2001-04-11 2006-01-10 Qlt, Inc. Drug delivery system for hydrophobic drugs
WO2003037295A2 (en) * 2001-11-02 2003-05-08 The Governors Of The University Of Alberta Micelle compositions containing pegylated phospholipids and a photosensitizer
EP1594875A4 (en) 2003-01-16 2007-07-11 Technomart Co Ltd PORPHYRINE DERIVATIVES
US20040220167A1 (en) * 2003-05-02 2004-11-04 Nasrollah Samiy Methods of treating neuralgic pain
JP4741205B2 (ja) * 2003-07-07 2011-08-03 真 湯浅 金属ポルフィリン錯体包埋リポソーム、その製造方法およびこれを利用する医薬
US8986731B2 (en) 2003-08-26 2015-03-24 Biolitec Pharma Marketing Ltd Pegylated liposomal formulations of hydrophobic photosensitizers for photodynamic therapy
US20050048109A1 (en) * 2003-08-26 2005-03-03 Ceramoptec Industries, Inc. Non-polar photosensitizer formulations for photodynamic therapy
US8709449B2 (en) * 2004-02-12 2014-04-29 Biolitec Pharma Marketing Ltd Methods and compositions for improving photodynamic therapy through administration of lipids
US20070031482A1 (en) * 2005-08-02 2007-02-08 Ceramoptec Industries, Ind. PDT treatment method for cellulites and cosmetic use
US20070178147A1 (en) * 2005-12-08 2007-08-02 Desai Narendra R Liposomal compositions
US7465312B2 (en) 2006-05-02 2008-12-16 Green Medical, Inc. Systems and methods for treating superficial venous malformations like spider veins
US20070299431A1 (en) * 2006-05-02 2007-12-27 Green Medical, Inc. Systems and methods for treating superficial venous malformations like spider veins
WO2007136633A2 (en) * 2006-05-18 2007-11-29 Ceramoptec Industries, Inc. Gel-formulations of hydrophobic photosensitizers for mucosal applications
WO2008088037A1 (ja) * 2007-01-18 2008-07-24 National University Corporation Chiba University 微粒子製剤
CN101861143B (zh) * 2007-11-15 2015-09-09 拜莱泰克制药市场有限公司 用于炎性疾病的光动力治疗的聚乙二醇化脂质体制剂
US9040079B2 (en) * 2007-11-19 2015-05-26 Biolitec Pharma Marketing Ltd Pegylated compounds for age-related macular degeneration
US20100310660A1 (en) * 2009-06-08 2010-12-09 Taipei Medical University Dry powder microparticles for pulmonary delivery
US9211214B2 (en) 2012-03-21 2015-12-15 Valeant Pharmaceuticals International, Inc Photodynamic therapy laser
KR102630617B1 (ko) * 2016-06-24 2024-01-29 (주) 에이치엔에이파마켐 페오포르비드 a 및 폴리에틸렌글리콜의 지질 유도체의 결합체를 함유하는 항균 리포좀 조성물
WO2019173884A1 (pt) * 2018-03-15 2019-09-19 Bebeachibuli Romeo Normalizador biológico, processo de obtenção de normalizador biológico e produtos obtidos com o normalizador biológico

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4649151A (en) * 1982-09-27 1987-03-10 Health Research, Inc. Drugs comprising porphyrins
JPS60188329A (ja) * 1984-03-07 1985-09-25 Ajinomoto Co Inc リポソ−ム封入物質移入促進剤
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
US4776991A (en) * 1986-08-29 1988-10-11 The United States Of America As Represented By The Secretary Of The Navy Scaled-up production of liposome-encapsulated hemoglobin
US4920143A (en) * 1987-04-23 1990-04-24 University Of British Columbia Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents
JPH0780887B2 (ja) * 1988-07-19 1995-08-30 ザ ユニバーシティ オブ ブリティッシュ コロンビア 波長特異的細胞毒性試薬
US4913907A (en) * 1988-08-15 1990-04-03 Cytopharm, Inc. Porphycene anti-cancer agents and treatment methods
US5010073A (en) * 1989-10-05 1991-04-23 The Rockefeller University Use of liposomes as carriers for metalloporphyrins
US5270053A (en) * 1990-04-03 1993-12-14 Ciba-Geigy Corp. Parenterally administerable liposome formulation comprising synthetic lipid
ATE108328T1 (de) * 1990-04-03 1994-07-15 Ciba Geigy Ag Parenteral applizierbare liposomenformulierung aus synthetischen lipiden.
CA2047969A1 (en) * 1990-08-17 1992-02-18 Thomas D. Madden Benzoporphyrin vesicles
GB9111611D0 (en) * 1991-05-30 1991-07-24 Sandoz Ltd Liposomes

Also Published As

Publication number Publication date
EP0569113B1 (en) 1997-04-23
KR970007303B1 (ko) 1997-05-07
JPH06122628A (ja) 1994-05-06
MX9300560A (es) 1993-09-01
JP3020372B2 (ja) 2000-03-15
DE69310014D1 (de) 1997-05-28
US6074666A (en) 2000-06-13
DK0569113T3 (da) 1997-05-20
EP0569113A1 (en) 1993-11-10
CA2087902A1 (en) 1993-08-06
DE69310014T2 (de) 1997-11-06
ATE151984T1 (de) 1997-05-15
GR3023906T3 (en) 1997-09-30
ES2100452T3 (es) 1997-06-16

Similar Documents

Publication Publication Date Title
CA2087902C (en) Liposome compositions of porphyrin photosensitizers
US6890555B1 (en) Liposome compositions of porphyrin photosensitizers
US5707608A (en) Methods of making liposomes containing hydro-monobenzoporphyrin photosensitizer
RU2279872C2 (ru) Система доставки лекарств для гидрофобных лекарственных препаратов
US7354599B2 (en) Liposomal formulations of hydrophobic photosensitizer for photodynamic therapy
EP1030686B1 (en) Lyophilizate of lipid complex of water insoluble porphyrins
JPH11509834A (ja) ヒドロ−モノベンゾポルフィリン光増感剤を含有するリポソームの作成方法
US6608050B2 (en) Lyophilizate of lipid complex of water insoluble porphyrins
EP1465590B1 (en) Micelle compositions containing pegylated phospholipids and a photosensitizer
AU2007202603B2 (en) Drug delivery system for hydrophobic drugs
AU2002252874B2 (en) Drug delivery system for hydrophobic drugs
AU2002252874A1 (en) Drug delivery system for hydrophobic drugs

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Effective date: 20130122