CA2082643A1 - Inhibiteurs de l'activation du facteur xii et leurs applications - Google Patents

Inhibiteurs de l'activation du facteur xii et leurs applications

Info

Publication number
CA2082643A1
CA2082643A1 CA 2082643 CA2082643A CA2082643A1 CA 2082643 A1 CA2082643 A1 CA 2082643A1 CA 2082643 CA2082643 CA 2082643 CA 2082643 A CA2082643 A CA 2082643A CA 2082643 A1 CA2082643 A1 CA 2082643A1
Authority
CA
Canada
Prior art keywords
antibody
factor xii
factor
inhibitor
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2082643
Other languages
English (en)
Inventor
Jan H. Nuijens
Cecile C. M. Huijbregts
C. Erik Hack
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Corp filed Critical Cetus Corp
Publication of CA2082643A1 publication Critical patent/CA2082643A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA 2082643 1990-05-10 1991-05-01 Inhibiteurs de l'activation du facteur xii et leurs applications Abandoned CA2082643A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52182090A 1990-05-10 1990-05-10
US521,820 1990-05-10

Publications (1)

Publication Number Publication Date
CA2082643A1 true CA2082643A1 (fr) 1991-11-11

Family

ID=24078300

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2082643 Abandoned CA2082643A1 (fr) 1990-05-10 1991-05-01 Inhibiteurs de l'activation du facteur xii et leurs applications

Country Status (4)

Country Link
EP (1) EP0534988A1 (fr)
AU (1) AU7793291A (fr)
CA (1) CA2082643A1 (fr)
WO (1) WO1991017258A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992015609A1 (fr) * 1991-03-11 1992-09-17 The General Hospital Corporation Compositions et procedes inhibant l'activation du facteur actif xiii
JP3213832B2 (ja) * 1993-08-06 2001-10-02 日本臓器製薬株式会社 被検物質の活性測定法
JP3213831B2 (ja) * 1993-08-06 2001-10-02 日本臓器製薬株式会社 被検物質の活性測定方法
US6903184B1 (en) 1998-03-02 2005-06-07 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Multiple antigenic peptides immunogenic against Streptococcus pneumonia
US9228186B2 (en) 2002-11-14 2016-01-05 Thermo Fisher Scientific Inc. Methods and compositions for selecting siRNA of improved functionality
GB0607515D0 (en) * 2006-04-13 2006-05-24 Axis Shield Diagnostics Ltd Anti-factor xlla therapy
EP2371857A1 (fr) 2010-04-01 2011-10-05 CSL Behring GmbH Inhibiteurs de facteur XII pour traiter la maladie de poumon interstitiel
LV14606B (lv) 2011-05-17 2013-01-20 Tetra, Sia Jauns XII faktora inhibitors
EP2548892A1 (fr) 2011-07-22 2013-01-23 CSL Behring GmbH Anticorps inhibiteurs monoclonal contre Factor XII/XIIa et leurs utilisations
KR102042982B1 (ko) * 2011-07-22 2019-11-11 체에스엘 베링 게엠베하 억제성 항-ｘｉｉ/ｘｉｉａ 인자 모노클로날 항체 및 이들의 사용
GB201121513D0 (en) 2011-12-14 2012-01-25 Cambridge Entpr Ltd Thrombin-binding antibody molecules and uses thereof
US9518128B2 (en) 2011-12-14 2016-12-13 Janssen Pharmaceuticals, Inc. Thrombin-binding antibody molecules
EP2623110A1 (fr) 2012-01-31 2013-08-07 CSL Behring GmbH Inhibiteurs de facteur XII pour le traitement de troubles inflammatoires neurologiques
US9574013B2 (en) * 2012-12-07 2017-02-21 Vanderbilt University Antibodies against factor XII and uses thereof
EP2964255B1 (fr) 2013-03-08 2020-11-04 CSL Behring GmbH Traitement et prévention d'une lésion d'ischémie-reperfusion à distance
CN105339010A (zh) 2013-06-28 2016-02-17 德国杰特贝林生物制品有限公司 使用因子xii抑制剂和c1-抑制剂的联合疗法
CN106456778A (zh) 2014-06-18 2017-02-22 德国杰特贝林生物制品有限公司 在神经创伤性病患中使用因子xii抑制剂进行治疗
IL253180B2 (en) 2015-01-02 2023-04-01 Dyax Corp Bispecific antibodies against plasma kallikrein and factor xii
CN116333144A (zh) 2015-07-21 2023-06-27 武田药品工业株式会社 一种因子xiia的单克隆抗体抑制剂
WO2019030706A1 (fr) 2017-08-10 2019-02-14 Janssen Pharmaceutica Nv Molécules d'anticorps anti-thrombine et méthodes d'utilisation en chirurgie orthopédique
WO2019035055A1 (fr) 2017-08-16 2019-02-21 Janssen Pharmaceutica Nv Molécules d'anticorps anti-thrombine et procédés d'utilisation avec des agents antiagrégants plaquettaires
EP3810270A1 (fr) * 2018-06-19 2021-04-28 Regeneron Pharmaceuticals, Inc. Anticorps anti-facteur xii/xiia et leurs utilisations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963657A (en) * 1988-06-09 1990-10-16 Temple University Of The Commonwealth System Of Higher Education Monoclonal antibodies to the light chain region of human factor XII and methods of preparing and using the same
GB8901859D0 (en) * 1989-01-27 1989-03-15 Shield Diagnostics Limited Diagnostic test

Also Published As

Publication number Publication date
EP0534988A1 (fr) 1993-04-07
AU7793291A (en) 1991-11-27
WO1991017258A1 (fr) 1991-11-14

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Legal Events

Date Code Title Description
FZDE Dead