CA2080346A1 - Gamma-butyrolactol ether derivatives - Google Patents

Gamma-butyrolactol ether derivatives

Info

Publication number
CA2080346A1
CA2080346A1 CA002080346A CA2080346A CA2080346A1 CA 2080346 A1 CA2080346 A1 CA 2080346A1 CA 002080346 A CA002080346 A CA 002080346A CA 2080346 A CA2080346 A CA 2080346A CA 2080346 A1 CA2080346 A1 CA 2080346A1
Authority
CA
Canada
Prior art keywords
pyridyl
gamma
general formula
ether
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002080346A
Other languages
English (en)
French (fr)
Inventor
Mark Whittaker
Alan Hornsby Davidson
Zoe Marie Spavold
Stephen Arthur Bowles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2080346A1 publication Critical patent/CA2080346A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA002080346A 1990-04-27 1991-04-16 Gamma-butyrolactol ether derivatives Abandoned CA2080346A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9009469.9 1990-04-27
GB909009469A GB9009469D0 (en) 1990-04-27 1990-04-27 Compounds

Publications (1)

Publication Number Publication Date
CA2080346A1 true CA2080346A1 (en) 1991-10-28

Family

ID=10675085

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002080346A Abandoned CA2080346A1 (en) 1990-04-27 1991-04-16 Gamma-butyrolactol ether derivatives

Country Status (13)

Country Link
US (1) US5428168A (enExample)
EP (1) EP0527817A1 (enExample)
JP (1) JPH05507064A (enExample)
AU (1) AU645082B2 (enExample)
CA (1) CA2080346A1 (enExample)
FI (1) FI924855A7 (enExample)
GB (1) GB9009469D0 (enExample)
IE (1) IE911328A1 (enExample)
NZ (1) NZ237779A (enExample)
PT (1) PT97503A (enExample)
TW (1) TW221999B (enExample)
WO (1) WO1991017157A1 (enExample)
ZA (1) ZA912715B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9114337D0 (en) * 1991-07-03 1991-08-21 British Bio Technology Compounds
GB9122308D0 (en) * 1991-10-21 1991-12-04 British Bio Technology Compounds
GB9202792D0 (en) * 1992-02-11 1992-03-25 British Bio Technology Compounds
JPH08502243A (ja) 1992-07-13 1996-03-12 サイトメッド，インコーポレイテッド 炎症性および免疫性疾患の治療のための２，５‐ジアリールテトラヒドロ‐チオフェン、‐フランおよび類似体
US5463083A (en) * 1992-07-13 1995-10-31 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5434151A (en) * 1992-08-24 1995-07-18 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
ATE253564T1 (de) * 1994-06-27 2003-11-15 Millenium Pharmaceuticals Inc Verbindungen und verfahren zur behandlung von cardiovaskulären, inflammatorischen und das immunsystem betreffende erkrankungen
US5792776A (en) * 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5703093A (en) * 1995-05-31 1997-12-30 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5750565A (en) * 1995-05-25 1998-05-12 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US6201016B1 (en) 1994-06-27 2001-03-13 Cytomed Incorporated Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
US6124463A (en) * 1998-07-02 2000-09-26 Dupont Pharmaceuticals Benzimidazoles as corticotropin release factor antagonists
HN2001000224A (es) * 2000-10-19 2002-06-13 Pfizer Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4539332A (en) * 1983-11-14 1985-09-03 Merck & Co., Inc. 2,5-Diaryl tetrahydrofurans and analogs thereof as PAF-antagonists
NZ215866A (en) * 1985-04-22 1989-11-28 Merck & Co Inc 2,5-di(aryl/heterocyclyl) tetrahydro-furans and pharmaceutical compositions
DE3666434D1 (de) * 1985-05-25 1989-11-23 Yoshitomi Pharmaceutical Oxodiazine compounds
JP2556849B2 (ja) * 1986-02-13 1996-11-27 三共株式会社 グリセリン誘導体
GB8701727D0 (en) * 1987-01-27 1987-03-04 Scras Tetrahydrofuran derivatives
US4820718A (en) * 1987-09-17 1989-04-11 Sandoz Pharm. Corp. N-alkyl-(2- or 5-substituted-2-methoxycarbonyl aminoalkyl furanyl)-substituted cyclimmonium salts and use thereof in PAF inhibition
GB8814340D0 (en) * 1988-06-16 1988-07-20 Ici Plc Process
ES2010568A6 (es) * 1988-08-04 1989-11-16 Uriach & Cia Sa J Procedimiento para la obtencion de derivados 2,5-disustituidos de tetrahidrofurano.

Also Published As

Publication number Publication date
FI924855A0 (fi) 1992-10-26
PT97503A (pt) 1992-01-31
GB9009469D0 (en) 1990-06-20
FI924855A7 (fi) 1992-10-26
AU7658591A (en) 1991-11-27
NZ237779A (en) 1992-11-25
JPH05507064A (ja) 1993-10-14
ZA912715B (en) 1992-03-25
WO1991017157A1 (en) 1991-11-14
IE911328A1 (en) 1991-11-06
TW221999B (enExample) 1994-04-01
EP0527817A1 (en) 1993-02-24
US5428168A (en) 1995-06-27
AU645082B2 (en) 1994-01-06

Similar Documents

Publication Publication Date Title
CA2080346A1 (en) Gamma-butyrolactol ether derivatives
CA1320202C (en) Nitro- or cyano-derivatives of 2-imino-imidazolines and 2-imino-tetrahydropyrimidines
JP2641443B2 (ja) ５Ｈ−１，３，４−チアジアゾロ〔３，２−ａ〕ピリミジン−５−オン誘導体及びこれを有効成分とする農園芸用殺菌剤
EP0239391B1 (en) 1,2,6-triphenyl-4(1H)-pyridinone and pyridinethione derivatives, production and uses thereof
RU2131421C1 (ru) Производные триазола, способы их получения, инсектицидное и акарицидное средство
EP0543858B1 (en) Benzimidazole derivatives, process for their preparation and application
RU2238937C2 (ru) Производные имидазола, фармацевтическая композиция и способ профилактики и/или лечения на их основе
US5180724A (en) Carboxamide amino acid heterobicyclic paf antagonists
US5741794A (en) Heterocyclic sulfonamide derivatives as antagonists of PAF and angiotensin II
US5274094A (en) Production of heterobicyclic containing benzene sulfonamides
RU2243220C2 (ru) Имидазольные соединения, способ их получения, способ ингибирования аденозиндезаминазы и фармацевтическая композиция на их основе
US5446032A (en) Imidazo (4,5-C) pyridine derivatives as PAF antagonists
US5637595A (en) Cyclic ether acetal PAF antagonists
Vollinga et al. A new convenient route for the synthesis of 4 (5)‐(ω‐aminoalkyl)‐1 H‐imidazoles
US4919707A (en) Derivative of 1,5-diphenyl-1H-1,2,4-triazole-3-carboxamide and herbicidal composition containing the same
DE4213257A1 (de) Fungizide (1h-1,2,4-triazolyl-)disilaalkane und verfahren zu ihrer herstellung
US5300524A (en) Spirocyclic PAF antagonists
JPH03167183A (ja) イミダゾール類
CZ3697A3 (en) 1,2,4,6-thiatriazines, process of their preparation, herbicidal agents in which they are comprised and their use
EP0445698B1 (en) Thiocarbamoylacetonitrile compounds
RU2014326C1 (ru) Производные имидазола
KR950010076B1 (ko) 신규 피라졸로[3,4-d]피리미딘 유도체, 그 제조방법 및 그로서 된 제초제
KR900003399B1 (ko) 피리딜 및 퀴놀릴 이미다졸리논류의 제법
PL97364B1 (pl) Sposob wytwarzania nowych zasadowych eterow enolowych oraz ich soli
JPH029587B2 (enExample)

Legal Events

Date Code Title Description
FZDE Discontinued