CA2079881A1 - Sequences nucleotidiques codant pour des regions variables de chaines .beta. des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques - Google Patents
Sequences nucleotidiques codant pour des regions variables de chaines .beta. des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiquesInfo
- Publication number
- CA2079881A1 CA2079881A1 CA002079881A CA2079881A CA2079881A1 CA 2079881 A1 CA2079881 A1 CA 2079881A1 CA 002079881 A CA002079881 A CA 002079881A CA 2079881 A CA2079881 A CA 2079881A CA 2079881 A1 CA2079881 A1 CA 2079881A1
- Authority
- CA
- Canada
- Prior art keywords
- diagnostic
- human
- variable regions
- chains
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
2079881 9213950 PCTABS00130 La présente invention concerne de nouvelles séquences nucléotidiques codant pour des régions variables de chaînes .beta. des récepteurs des lymphocytes T humains, les segments peptidiques correspondants et les applications diagnostiques et thérapeutiques.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR91/01613 | 1990-02-12 | ||
FR9101613A FR2672617B1 (fr) | 1991-02-12 | 1991-02-12 | Sequences nucleotidiques codant pour des regions variables de chaines beta des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques. |
FR9104523A FR2675155A1 (fr) | 1991-04-12 | 1991-04-12 | Sequences nucleotidiques codant pour des regions variables de chaines beta des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques. |
FR91/04523 | 1991-04-12 | ||
PCT/FR1992/000130 WO1992013950A2 (fr) | 1991-02-12 | 1992-02-12 | SEQUENCES NUCLEOTIDIQUES CODANT POUR DES REGIONS VARIABLES DE CHAINES β DES RECEPTEURS DES LYMPHOCYTES T HUMAINS, SEGMENTS PEPTIDIQUES CORRESPONDANTS ET LES APPLICATIONS DIAGNOSTIQUES ET THERAPEUTIQUES |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2079881A1 true CA2079881A1 (fr) | 1992-08-13 |
CA2079881C CA2079881C (fr) | 2007-11-06 |
Family
ID=26228507
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002079881A Expired - Lifetime CA2079881C (fr) | 1991-02-12 | 1992-02-12 | Sequences nucleotidiques codant pour des regions variables de chaines .beta. des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques |
Country Status (8)
Country | Link |
---|---|
US (3) | US5700907A (fr) |
EP (1) | EP0528007A1 (fr) |
JP (1) | JPH06502997A (fr) |
KR (2) | KR100227303B1 (fr) |
AU (1) | AU660306B2 (fr) |
CA (1) | CA2079881C (fr) |
IE (1) | IE920447A1 (fr) |
WO (1) | WO1992013950A2 (fr) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5776459A (en) * | 1989-07-19 | 1998-07-07 | Connetics Corporation | TCR V beta 5 peptides |
US5098303A (en) * | 1990-03-22 | 1992-03-24 | Ultradent Products, Inc. | Method for bleaching teeth |
US7294712B2 (en) * | 1990-06-04 | 2007-11-13 | Aventis Pharma S.A. | Nucleotide sequences coding for variable regions of β chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses |
EP0528007A1 (fr) * | 1991-02-12 | 1993-02-24 | Roussel Uclaf | SEQUENCES NUCLEOTIDIQUES CODANT POUR DES REGIONS VARIABLES DE CHAINES $g(b) DES RECEPTEURS DES LYMPHOCYTES T HUMAINS, SEGMENTS PEPTIDIQUES CORRESPONDANTS ET LES APPLICATIONS DIAGNOSTIQUES ET THERAPEUTIQUES |
US5552300A (en) * | 1994-01-13 | 1996-09-03 | T Cell Sciences, Inc. | T cell antigen receptor V region proteins and methods of preparation thereof |
FR2736831B1 (fr) * | 1995-07-19 | 1997-08-22 | Centre Nat Rech Scient | Sequences nucleotidiques et peptidiques pour le traitement de la myasthenie |
US6087096A (en) * | 1995-11-13 | 2000-07-11 | Dau; Peter C. | Method of intrafamily fragment analysis of the T cell receptor α and β chain CDR3 regions |
AU1744500A (en) * | 1998-11-25 | 2000-06-13 | University Of Cincinnati, The | Polymorphisms in the 5' leader cistron of the beta2-adrenergic receptor |
US6861217B1 (en) | 1998-11-25 | 2005-03-01 | Genaissance Pharmaceuticals, Inc. | Variation in drug response related to polymorphisms in the β2-adrenergic receptor |
WO2004005465A2 (fr) * | 2002-07-03 | 2004-01-15 | Institute For Scientific Research, Inc. | Compositions et procedes de detection de l'expression de genes d'une famille variable de recepteurs de lymphocytes t humains |
US7375211B2 (en) * | 2005-11-18 | 2008-05-20 | Kou Zhong C | Method for detection and quantification of T-cell receptor Vβ repertoire |
EP2044949A1 (fr) | 2007-10-05 | 2009-04-08 | Immutep | Utilisation de lag-3 recombinant ou ses dérivatifs pour déclencher la réponse immune des monocytes |
US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
CN104195227B (zh) | 2008-11-07 | 2017-04-12 | 适应生物技术公司 | 通过序列分析监测状况的方法 |
EP2387627B1 (fr) | 2009-01-15 | 2016-03-30 | Adaptive Biotechnologies Corporation | Profilage d'immunité adaptative et méthodes de génération d'anticorps monoclonaux |
RU2014144463A (ru) | 2009-06-25 | 2015-06-20 | Фред Хатчинсон Кансэр Рисёч Сентер | Способ измерения адаптивного иммунитета |
US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
EP2768982A4 (fr) | 2011-10-21 | 2015-06-03 | Adaptive Biotechnologies Corp | Quantification de génomes de cellules immunitaires adaptatives dans un mélange complexe de cellules |
EP2788509B1 (fr) | 2011-12-09 | 2018-07-11 | Adaptive Biotechnologies Corporation | Diagnostic des malignités lymphoïdes et détection de maladie résiduelle minimale |
US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
WO2013134162A2 (fr) | 2012-03-05 | 2013-09-12 | Sequenta, Inc. | Détermination de chaînes appariées de récepteurs immuns à partir de sous-unités présentant une fréquence correspondante |
RU2631797C2 (ru) | 2012-05-08 | 2017-09-26 | Эдэптив Байотекнолоджиз Корпорейшн | Композиции и способы измерения и калибровки систематической ошибки амплификации в мультиплексных пцр-реакциях |
ES2660027T3 (es) | 2012-10-01 | 2018-03-20 | Adaptive Biotechnologies Corporation | Evaluación de la inmunocompetencia por la diversidad de los receptores de inmunidad adaptativa y caracterización de la clonalidad |
GB2525568B (en) | 2013-03-15 | 2020-10-14 | Abvitro Llc | Single cell barcoding for antibody discovery |
US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
GB201322626D0 (en) | 2013-12-19 | 2014-02-05 | Immutep S A | Combined preparations for the treatment of cancer |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
EP3114240B1 (fr) | 2014-03-05 | 2019-07-24 | Adaptive Biotechnologies Corporation | Procédés dans lesquels on utilise des molécules synthétiques contenant des randomères |
CR20160425A (es) | 2014-03-14 | 2017-05-26 | Novartis Ag | Moléculas de anticuerpos que se unen a lag-3 y usos de las mismas |
US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
US11390921B2 (en) | 2014-04-01 | 2022-07-19 | Adaptive Biotechnologies Corporation | Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs) |
EP3132059B1 (fr) | 2014-04-17 | 2020-01-08 | Adaptive Biotechnologies Corporation | Quantification de génomes de cellules de l'immunité acquise dans un mélange complexe de cellules |
ES2895750T3 (es) | 2014-09-15 | 2022-02-22 | Abvitro Llc | Secuenciación de alto rendimiento de colecciones de nucleótidos |
EP3715455A1 (fr) | 2014-10-29 | 2020-09-30 | Adaptive Biotechnologies Corp. | Détection simultanée hautement multiplexée d'acides nucléiques codant pour des hétérodimères de récepteurs de l'immunité adaptative appariés à partir de nombreux échantillons |
US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
CA2968543C (fr) | 2014-11-25 | 2024-04-02 | Adaptive Biotechnologies Corporation | Caracterisation de la reponse immunitaire adaptative a la vaccination ou a l'infection a l'aide du sequencage du repertoire immunitaire |
GB201500374D0 (en) | 2015-01-09 | 2015-02-25 | Immutep S A | Combined preparations for the treatment of cancer |
AU2016222788B2 (en) | 2015-02-24 | 2022-03-31 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining HLA status using immune repertoire sequencing |
WO2016161273A1 (fr) | 2015-04-01 | 2016-10-06 | Adaptive Biotechnologies Corp. | Procédé d'identification des récepteurs de lymphocytes t spécifiques à compatibilité humaine pour une cible antigénique |
US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG70553A1 (en) * | 1984-03-01 | 2000-02-22 | Univ Leland Stanford Junior | T-cell receptor-specific for antigen polypeptides and related polynucleotides |
US4786590A (en) * | 1985-01-15 | 1988-11-22 | California Institute Of Technology | Diagnostic and therapeutic aspects of receptor-mediated leukemogenesis |
US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4886743A (en) * | 1985-04-24 | 1989-12-12 | California Institute Of Technology | Diagnostic reagents based on unique sequences within the variable region of the T cell receptor and uses thereof |
US4743679A (en) * | 1986-02-24 | 1988-05-10 | Creative Biomolecules, Inc. | Process for producing human epidermal growth factor and analogs thereof |
US6194561B1 (en) * | 1986-03-13 | 2001-02-27 | Roche Molecular Systems, Inc. | Characterization and detection of sequences associated with autoimmune diseases |
US4892827A (en) * | 1986-09-24 | 1990-01-09 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects |
JPH02441A (ja) * | 1986-11-19 | 1990-01-05 | Mitsui Toatsu Chem Inc | 遺伝子複合体及びこれを用いる診断法 |
US5447839A (en) * | 1988-09-09 | 1995-09-05 | Hoffmann-La Roche Inc. | Detection of human papillomavirus by the polymerase chain reaction |
WO1990004648A1 (fr) * | 1988-10-20 | 1990-05-03 | Alexander Alan Morley | Methode pour le diagnostic de la monoclonalite dans la leucemie et le lymphome |
US5223426A (en) * | 1988-12-15 | 1993-06-29 | T Cell Sciences, Inc. | Monoclonal antibodies reactive with defined regions of the t-cell antigen receptor |
US5043272A (en) * | 1989-04-27 | 1991-08-27 | Life Technologies, Incorporated | Amplification of nucleic acid sequences using oligonucleotides of random sequence as primers |
KR100242278B1 (ko) * | 1991-02-08 | 2000-02-01 | 장-끌로드 비에이으포스 | 인체 임파구 수용체의 알파사슬의 가변성영역을 코딩하는 뉴클레오티드 서열 및 그의 응용 |
EP0528007A1 (fr) * | 1991-02-12 | 1993-02-24 | Roussel Uclaf | SEQUENCES NUCLEOTIDIQUES CODANT POUR DES REGIONS VARIABLES DE CHAINES $g(b) DES RECEPTEURS DES LYMPHOCYTES T HUMAINS, SEGMENTS PEPTIDIQUES CORRESPONDANTS ET LES APPLICATIONS DIAGNOSTIQUES ET THERAPEUTIQUES |
US6084087A (en) * | 1991-09-27 | 2000-07-04 | New York Society For The Ruptured And Crippled Maintaing The Hospital For Special Surgery | DNA encoding conserved T-cell receptor sequences |
-
1992
- 1992-02-12 EP EP92906703A patent/EP0528007A1/fr not_active Withdrawn
- 1992-02-12 AU AU15445/92A patent/AU660306B2/en not_active Expired
- 1992-02-12 CA CA002079881A patent/CA2079881C/fr not_active Expired - Lifetime
- 1992-02-12 JP JP4506380A patent/JPH06502997A/ja active Pending
- 1992-02-12 KR KR1019920702512A patent/KR100227303B1/ko not_active IP Right Cessation
- 1992-02-12 IE IE044792A patent/IE920447A1/en unknown
- 1992-02-12 WO PCT/FR1992/000130 patent/WO1992013950A2/fr not_active Application Discontinuation
-
1995
- 1995-04-14 US US08/423,383 patent/US5700907A/en not_active Expired - Lifetime
- 1995-05-09 US US08/437,353 patent/US5830758A/en not_active Expired - Lifetime
-
1999
- 1999-05-26 KR KR1019997004635A patent/KR100297082B1/ko not_active IP Right Cessation
-
2007
- 2007-10-05 US US11/867,862 patent/US8709426B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1992013950A2 (fr) | 1992-08-20 |
US5830758A (en) | 1998-11-03 |
WO1992013950A3 (fr) | 1993-02-04 |
KR930700658A (ko) | 1993-03-15 |
US20080069770A1 (en) | 2008-03-20 |
JPH06502997A (ja) | 1994-04-07 |
AU1544592A (en) | 1992-09-07 |
CA2079881C (fr) | 2007-11-06 |
US8709426B2 (en) | 2014-04-29 |
IE920447A1 (en) | 1992-08-12 |
KR100297082B1 (ko) | 2001-09-22 |
EP0528007A1 (fr) | 1993-02-24 |
US5700907A (en) | 1997-12-23 |
KR100227303B1 (ko) | 1999-12-01 |
AU660306B2 (en) | 1995-06-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2079881A1 (fr) | Sequences nucleotidiques codant pour des regions variables de chaines .beta. des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques | |
ZA91134B (en) | New proteins produced by human lymphocytes,dna sequence encoding these proteins and their pharmaceutical and biological uses | |
ES2142953T3 (es) | Factor de crecimiento y diferenciacion de la familia del tgf-beta. | |
EP0723555A4 (fr) | Proteines chimeriques avec activation de complement en bloc | |
ATE262038T1 (de) | Br96 mutantantikörper die mit menschlichen karzinomen reagieren | |
EP0741188A3 (fr) | Insuline monocaténaire avec bioactivité élevée | |
DE3750113T2 (de) | Für menschliche "Colony-stimulating"-Faktoren kodierendes Gen. | |
AU8635391A (en) | Nucleotide sequences coding for a human protein with angiogenesis regulative properties | |
ES2192620T3 (es) | Polipeptido receptor de il-13. | |
DK0728148T3 (da) | Forbedrede immunogene sammensætninger mod humant gastrin 17 | |
IL117459A (en) | Dna encoding human papillomavirus type 18 | |
AU1431188A (en) | Dihydropyridine - pyridinium salt-type redox amino acids and peptides containing them | |
DE59100763D1 (de) | Elektrode für medizinische Anwendungen. | |
DE69526087T2 (de) | Or-1, ein wais-rezeptor der nuklearen rezeptoren familie | |
EP0870036A4 (fr) | Alpha-n-acetylglucosaminidase synthetique de mammifere et sequences genetiques la codant | |
PE20399A1 (es) | Muteina ob | |
ES2105261T3 (es) | Polipeptidos bloqueantes de canales de calcio aislados de filistata hibernalis. | |
TW342413B (en) | Novel toxins isolated from Bracon Hebetor | |
FR2672617B1 (fr) | Sequences nucleotidiques codant pour des regions variables de chaines beta des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques. | |
FR2675156B1 (fr) | Sequences nucleotidiques codant pour des regions variables de chaines alpha des recepteurs des lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques. | |
FR2672616B1 (fr) | Sequences nucleotidiques codant pour des regions variables de chaines alpha des recepteurs de lymphocytes t humains, segments peptidiques correspondants et les applications diagnostiques et therapeutiques. | |
GB2325466A (en) | Nucleotide sequence from goat liver | |
DK0858465T3 (da) | Protein med antitumorvirkning. | |
ATE75255T1 (de) | Peptid und dafuer kodierendes gen. | |
MX9703506A (es) | Acilacion selectiva de grupos epsilon-amino. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |