CA2067759A1 - Derives du 3-phenylglutarimide comme antagonistes des recepteurs muscariniques - Google Patents

Derives du 3-phenylglutarimide comme antagonistes des recepteurs muscariniques

Info

Publication number
CA2067759A1
CA2067759A1 CA2067759A CA2067759A CA2067759A1 CA 2067759 A1 CA2067759 A1 CA 2067759A1 CA 2067759 A CA2067759 A CA 2067759A CA 2067759 A CA2067759 A CA 2067759A CA 2067759 A1 CA2067759 A1 CA 2067759A1
Authority
CA
Canada
Prior art keywords
alkyl
independently
receptor antagonists
muscarinic receptor
phenyglutarimide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2067759A
Other languages
English (en)
Other versions
CA2067759C (fr
Inventor
Alexander Roderick Mackenzie
Peter Edward Cross
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Alexander Roderick Mackenzie
Peter Edward Cross
Pfizer Limited
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexander Roderick Mackenzie, Peter Edward Cross, Pfizer Limited, Pfizer Inc. filed Critical Alexander Roderick Mackenzie
Publication of CA2067759A1 publication Critical patent/CA2067759A1/fr
Application granted granted Critical
Publication of CA2067759C publication Critical patent/CA2067759C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002067759A 1989-12-12 1990-11-28 Derives du 3-phenylglutarimide comme antagonistes des recepteurs muscariniques Expired - Fee Related CA2067759C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898928043A GB8928043D0 (en) 1989-12-12 1989-12-12 Muscarinic receptor antagonists
GB8928043.2 1989-12-12

Publications (2)

Publication Number Publication Date
CA2067759A1 true CA2067759A1 (fr) 1991-06-13
CA2067759C CA2067759C (fr) 1996-09-10

Family

ID=10667814

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002067759A Expired - Fee Related CA2067759C (fr) 1989-12-12 1990-11-28 Derives du 3-phenylglutarimide comme antagonistes des recepteurs muscariniques

Country Status (13)

Country Link
US (1) US5300516A (fr)
EP (1) EP0505379B1 (fr)
JP (1) JPH0686428B2 (fr)
AT (1) ATE108776T1 (fr)
CA (1) CA2067759C (fr)
DE (1) DE69010917T2 (fr)
DK (1) DK0505379T3 (fr)
ES (1) ES2057601T3 (fr)
FI (1) FI96024C (fr)
GB (1) GB8928043D0 (fr)
IE (1) IE63421B1 (fr)
PT (1) PT96142B (fr)
WO (1) WO1991009014A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9602516D0 (en) * 1996-02-08 1996-04-10 Chiroscience Ltd Racemisation
DE10002509A1 (de) * 2000-01-21 2001-07-26 Gruenenthal Gmbh Substituierte Glutarimide
MX2018007152A (es) * 2015-12-14 2018-08-15 Ironwood Pharmaceuticals Inc Uso de estimuladores de guanilato ciclasa soluble (sgc) para el tratamiento de la disfuncion del esfinter gastrointestinal.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2664424A (en) * 1953-12-29 Dioxo-piperidines
US2848455A (en) * 1955-07-18 1958-08-19 Ciba Pharm Prod Inc Alpha-(p-amino-phenyl)-alpha-lower alkyl glutarimides
BE632403A (fr) * 1962-05-17 1900-01-01
GB1455687A (en) * 1972-12-28 1976-11-17 Aspro Nicholas Ltd Pharmacologically active 3-phenyl-3-aminoalkyl-2,6-dioxo-hydro genated pyridines
GB8716338D0 (en) * 1987-07-10 1987-08-19 Nat Res Dev Anti-anxiogenic compositions

Also Published As

Publication number Publication date
ATE108776T1 (de) 1994-08-15
CA2067759C (fr) 1996-09-10
IE63421B1 (en) 1995-04-19
US5300516A (en) 1994-04-05
FI922342A (fi) 1992-05-22
FI96024C (fi) 1996-04-25
JPH04505926A (ja) 1992-10-15
EP0505379A1 (fr) 1992-09-30
ES2057601T3 (es) 1994-10-16
GB8928043D0 (en) 1990-02-14
FI96024B (fi) 1996-01-15
JPH0686428B2 (ja) 1994-11-02
DE69010917T2 (de) 1994-11-03
DE69010917D1 (de) 1994-08-25
WO1991009014A1 (fr) 1991-06-27
IE904461A1 (en) 1991-06-19
FI922342A0 (fi) 1992-05-22
PT96142B (pt) 1997-05-28
PT96142A (pt) 1991-09-30
DK0505379T3 (da) 1994-09-12
EP0505379B1 (fr) 1994-07-20

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed