CA2069910A1 - Antagonistes du recepteur muscarinique - Google Patents
Antagonistes du recepteur muscariniqueInfo
- Publication number
- CA2069910A1 CA2069910A1 CA2069910A CA2069910A CA2069910A1 CA 2069910 A1 CA2069910 A1 CA 2069910A1 CA 2069910 A CA2069910 A CA 2069910A CA 2069910 A CA2069910 A CA 2069910A CA 2069910 A1 CA2069910 A1 CA 2069910A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- receptor antagonists
- muscarinic receptor
- formula
- nconr6r7
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 8
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- -1 -(CH2)nOH Chemical group 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898928042A GB8928042D0 (en) | 1989-12-12 | 1989-12-12 | Muscarinic receptor antagonists |
| GB8928042.4 | 1989-12-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2069910A1 true CA2069910A1 (fr) | 1991-06-13 |
| CA2069910C CA2069910C (fr) | 1996-11-12 |
Family
ID=10667813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002069910A Expired - Fee Related CA2069910C (fr) | 1989-12-12 | 1990-11-28 | Antagonistes du recepteur muscarinique |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5340831A (fr) |
| EP (1) | EP0505376B1 (fr) |
| JP (1) | JPH0678303B2 (fr) |
| AT (1) | ATE115126T1 (fr) |
| CA (1) | CA2069910C (fr) |
| DE (1) | DE69014901T2 (fr) |
| DK (1) | DK0505376T3 (fr) |
| ES (1) | ES2064771T3 (fr) |
| FI (1) | FI95027C (fr) |
| GB (1) | GB8928042D0 (fr) |
| GR (1) | GR3014907T3 (fr) |
| IE (1) | IE64205B1 (fr) |
| PT (1) | PT96144A (fr) |
| WO (1) | WO1991009013A1 (fr) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6017931A (en) * | 1994-03-01 | 2000-01-25 | Fmc Corporation | Insecticidal compositions containing n-(substituted phenylmethyl)-4-[bis(substituted phenyl)methyl]piperidines |
| US5639763A (en) * | 1994-03-01 | 1997-06-17 | Fmc Corporation | Insecticidal N-(substituted arylmethyl)-4-[bis(substituted phenyl)methyl]piperidines |
| US5569664A (en) * | 1995-02-16 | 1996-10-29 | Fmc Corporation | Insecticidal n-(substituted arylmethyl)-4-[bis(substituted phenyl) methyl]pi |
| EP0948964B1 (fr) * | 1996-12-02 | 2003-04-02 | Kyorin Pharmaceutical Co., Ltd. | Nouveaux derives de pyrrolidine n-substitues et procede de preparation de ces derives |
| US6693202B1 (en) * | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| CN1668585A (zh) | 2002-07-08 | 2005-09-14 | 兰贝克赛实验室有限公司 | 用作蝇蕈碱受体拮抗剂的3,6－二取代氮杂双环[3.1.0]己烷衍生物 |
| US7265147B2 (en) | 2002-07-31 | 2007-09-04 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists |
| US7410993B2 (en) | 2002-08-09 | 2008-08-12 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0] hexane deriviatives useful as muscarinic receptor antagonists |
| US7288562B2 (en) | 2002-08-23 | 2007-10-30 | Ranbaxy Laboratories Limited | Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists |
| TWI295669B (en) * | 2002-10-30 | 2008-04-11 | Theravance Inc | Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds |
| JP2006518707A (ja) | 2002-12-10 | 2006-08-17 | ランバクシー ラボラトリーズ リミテッド | ムスカリン様受容体アンタゴニストとしての３，６−二置換アザビシクロ［３．１．０］ヘキサン誘導体 |
| WO2004056767A1 (fr) | 2002-12-23 | 2004-07-08 | Ranbaxy Laboratories Limited | Derives de 1-substitues-3-pyrrolidines comme antagonistes de recepteurs muscariniques |
| ATE386738T1 (de) | 2002-12-23 | 2008-03-15 | Ranbaxy Lab Ltd | Flavaxat-derivate als muscarin-rezeptor antagonisten |
| US7488748B2 (en) | 2003-01-28 | 2009-02-10 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| WO2004089892A2 (fr) | 2003-04-01 | 2004-10-21 | Theravance, Inc. | Diarylmethyle et composes apparentes |
| AU2003214520A1 (en) | 2003-04-09 | 2004-11-01 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| EP1615887A1 (fr) | 2003-04-10 | 2006-01-18 | Ranbaxy Laboratories, Ltd. | Derives d'azabicyclo hexanes en tant qu'antagonistes des recepteurs muscariniques |
| AU2003214535B2 (en) | 2003-04-10 | 2009-09-03 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| WO2004089900A1 (fr) | 2003-04-11 | 2004-10-21 | Ranbaxy Laboratories Limited | Derives azabicyclo utiles comme antagonistes du recepteur muscarinique |
| TW200510298A (en) | 2003-06-13 | 2005-03-16 | Theravance Inc | Substituted pyrrolidine and related compounds |
| WO2005007645A1 (fr) * | 2003-07-11 | 2005-01-27 | Theravance, Inc. | Composes de 4-amino-1-benzylpiperidine substitues |
| US7250414B2 (en) * | 2004-03-11 | 2007-07-31 | Theravance, Inc. | Diphenylmethyl compounds useful as muscarinic receptor antagonists |
| EP1725525A1 (fr) * | 2004-03-11 | 2006-11-29 | Theravance, Inc. | Composes biphenyle convenant en tant qu'antagonistes du recepteur muscarinique |
| EP1926709A4 (fr) | 2005-08-25 | 2009-06-24 | Rstech Corp | Procédé de synthèse d'un composé chiral de type 3-hydroxypyrrolidine et de dérivés dudit composé de pureté optique élevée |
| JP2009512676A (ja) | 2005-10-19 | 2009-03-26 | ランバクシー ラボラトリーズ リミテッド | ムスカリン性受容体アンタゴニストの医薬組成物 |
| CA2630478A1 (fr) * | 2005-12-27 | 2007-07-05 | Teva Pharmaceutical Industries, Ltd | Procedes de preparation de bromhydrate de darifenacine |
| JP5528817B2 (ja) | 2007-02-23 | 2014-06-25 | セラヴァンス， インコーポレーテッド | ムスカリン受容体アンタゴニストとして有用な第四級アンモニウムジフェニルメチル化合物 |
| JP2010525058A (ja) | 2007-04-24 | 2010-07-22 | セラヴァンス， インコーポレーテッド | ムスカリン受容体アンタゴニストとして有用な第４級アンモニウム化合物 |
| JP5779100B2 (ja) | 2008-11-24 | 2015-09-16 | カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ | 光学的に活性なｎ−ベンジル−３−ヒドロキシピロリジンの製造方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL76583A (en) * | 1984-10-19 | 1988-08-31 | Robins Co Inc A H | 1-(aminoalkyl)-alpha'alpha-diaryl pyrrolidinyl,piperidino and homopiperidino acetamides and acetonitriles and pharmaceutical compositions containing them |
| US4810713A (en) * | 1985-12-20 | 1989-03-07 | A. H. Robins Company, Incorporated | Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment |
| EP0235463A3 (fr) * | 1985-12-20 | 1990-01-17 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | Arylalkyl et arylalkylène piperidines substitués sur l'azote utilisés comme agents antihistaminiques cardiovasculaires et antisécrétion |
| IN163948B (fr) * | 1986-01-17 | 1988-12-10 | Robins Co Inc A H | |
| US5233053A (en) * | 1989-03-17 | 1993-08-03 | Pfizer Inc. | Pyrrolidine derivatives |
| GB8906166D0 (en) * | 1989-03-17 | 1989-05-04 | Pfizer Ltd | Therapeutic agents |
-
1989
- 1989-12-12 GB GB898928042A patent/GB8928042D0/en active Pending
-
1990
- 1990-11-28 AT AT90917056T patent/ATE115126T1/de not_active IP Right Cessation
- 1990-11-28 JP JP2515786A patent/JPH0678303B2/ja not_active Expired - Fee Related
- 1990-11-28 DK DK90917056.5T patent/DK0505376T3/da active
- 1990-11-28 WO PCT/EP1990/002043 patent/WO1991009013A1/fr active IP Right Grant
- 1990-11-28 DE DE69014901T patent/DE69014901T2/de not_active Expired - Fee Related
- 1990-11-28 EP EP90917056A patent/EP0505376B1/fr not_active Expired - Lifetime
- 1990-11-28 ES ES90917056T patent/ES2064771T3/es not_active Expired - Lifetime
- 1990-11-28 CA CA002069910A patent/CA2069910C/fr not_active Expired - Fee Related
- 1990-11-29 US US07/859,471 patent/US5340831A/en not_active Expired - Lifetime
- 1990-12-10 PT PT96144A patent/PT96144A/pt unknown
- 1990-12-11 IE IE446390A patent/IE64205B1/en not_active IP Right Cessation
-
1992
- 1992-05-22 FI FI922345A patent/FI95027C/fi not_active IP Right Cessation
-
1995
- 1995-02-01 GR GR940404057T patent/GR3014907T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0505376B1 (fr) | 1994-12-07 |
| EP0505376A1 (fr) | 1992-09-30 |
| FI922345A (fi) | 1992-05-22 |
| IE904463A1 (en) | 1991-06-19 |
| IE64205B1 (en) | 1995-07-12 |
| ES2064771T3 (es) | 1995-02-01 |
| PT96144A (pt) | 1991-09-30 |
| GR3014907T3 (en) | 1995-05-31 |
| US5340831A (en) | 1994-08-23 |
| CA2069910C (fr) | 1996-11-12 |
| JPH0678303B2 (ja) | 1994-10-05 |
| ATE115126T1 (de) | 1994-12-15 |
| DE69014901T2 (de) | 1995-04-27 |
| WO1991009013A1 (fr) | 1991-06-27 |
| FI95027C (fi) | 1995-12-11 |
| FI95027B (fi) | 1995-08-31 |
| DE69014901D1 (de) | 1995-01-19 |
| JPH04505927A (ja) | 1992-10-15 |
| DK0505376T3 (da) | 1995-02-13 |
| GB8928042D0 (en) | 1990-02-14 |
| FI922345A0 (fi) | 1992-05-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2069910A1 (fr) | Antagonistes du recepteur muscarinique | |
| CA2067817A1 (fr) | Antagonistes des recepteurs muscariniques | |
| WO1992005172A3 (fr) | Antagonistes de recepteurs muscariniques | |
| CA2081766A1 (fr) | Antagonistes du leucotriene b4 | |
| MY105527A (en) | Pyrrolidine derivatives. | |
| GB9000301D0 (en) | Piperidine & pyrrolidine derivatives | |
| GB9000304D0 (en) | Muscarinic receptor antagonists | |
| GR3023974T3 (en) | Muscarinic receptor antagonists | |
| AU4258389A (en) | Muscarinic receptor antagonists | |
| CA2067759A1 (fr) | Derives du 3-phenylglutarimide comme antagonistes des recepteurs muscariniques | |
| CA2069931A1 (fr) | Antagonistes du recepteur muscarinique |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |