FI922345A - Menetelmä terapeuttisesti käyttökelpoisten 3-substituoitujen pyrrolidiinijohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten 3-substituoitujen pyrrolidiinijohdannaisten valmistamiseksi Download PDF

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Publication number
FI922345A
FI922345A FI922345A FI922345A FI922345A FI 922345 A FI922345 A FI 922345A FI 922345 A FI922345 A FI 922345A FI 922345 A FI922345 A FI 922345A FI 922345 A FI922345 A FI 922345A
Authority
FI
Finland
Prior art keywords
alkyl
pct
preparation
therapeutically useful
date jun
Prior art date
Application number
FI922345A
Other languages
English (en)
Swedish (sv)
Other versions
FI95027C (fi
FI922345A0 (fi
FI95027B (fi
Inventor
Alexander Roderick Mackenzie
Peter Edward Cross
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI922345A0 publication Critical patent/FI922345A0/fi
Publication of FI922345A publication Critical patent/FI922345A/fi
Application granted granted Critical
Publication of FI95027B publication Critical patent/FI95027B/fi
Publication of FI95027C publication Critical patent/FI95027C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
FI922345A 1989-12-12 1992-05-22 Menetelmä terapeuttisesti käyttökelpoisten 3-substituoitujen pyrrolidiinijohdannaisten valmistamiseksi FI95027C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB898928042A GB8928042D0 (en) 1989-12-12 1989-12-12 Muscarinic receptor antagonists
GB8928042 1989-12-12
PCT/EP1990/002043 WO1991009013A1 (en) 1989-12-12 1990-11-28 Muscarinic receptor antagonists
EP9002043 1990-11-28

Publications (4)

Publication Number Publication Date
FI922345A0 FI922345A0 (fi) 1992-05-22
FI922345A true FI922345A (fi) 1992-05-22
FI95027B FI95027B (fi) 1995-08-31
FI95027C FI95027C (fi) 1995-12-11

Family

ID=10667813

Family Applications (1)

Application Number Title Priority Date Filing Date
FI922345A FI95027C (fi) 1989-12-12 1992-05-22 Menetelmä terapeuttisesti käyttökelpoisten 3-substituoitujen pyrrolidiinijohdannaisten valmistamiseksi

Country Status (14)

Country Link
US (1) US5340831A (fi)
EP (1) EP0505376B1 (fi)
JP (1) JPH0678303B2 (fi)
AT (1) ATE115126T1 (fi)
CA (1) CA2069910C (fi)
DE (1) DE69014901T2 (fi)
DK (1) DK0505376T3 (fi)
ES (1) ES2064771T3 (fi)
FI (1) FI95027C (fi)
GB (1) GB8928042D0 (fi)
GR (1) GR3014907T3 (fi)
IE (1) IE64205B1 (fi)
PT (1) PT96144A (fi)
WO (1) WO1991009013A1 (fi)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6017931A (en) * 1994-03-01 2000-01-25 Fmc Corporation Insecticidal compositions containing n-(substituted phenylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
US5569664A (en) * 1995-02-16 1996-10-29 Fmc Corporation Insecticidal n-(substituted arylmethyl)-4-[bis(substituted phenyl) methyl]pi
US5639763A (en) * 1994-03-01 1997-06-17 Fmc Corporation Insecticidal N-(substituted arylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
CA2273253C (en) * 1996-12-02 2003-09-16 Kyorin Pharmaceutical Co., Ltd. Novel n-substituted pyrrolidine derivatives and process for preparing the same
US6693202B1 (en) 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
CA2492121A1 (en) 2002-07-08 2004-01-15 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
ATE396969T1 (de) 2002-07-31 2008-06-15 Ranbaxy Lab Ltd 3,6-disubstituierte azabicyclo (3.1.0)hexanderivate, die sich als muscarinrezeptorantagonisten eignen
AU2002321711A1 (en) 2002-08-09 2004-02-25 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives useful as muscarinic receptor antagonist
EP1534675B1 (en) 2002-08-23 2009-02-25 Ranbaxy Laboratories, Ltd. Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo¬3.1.0 hexane derivatives as muscarinic receptor antagonists
TW200800953A (en) * 2002-10-30 2008-01-01 Theravance Inc Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine
EP1572648B1 (en) 2002-12-10 2008-07-09 Ranbaxy Laboratories, Ltd. 3,6-disubstituted azabicyclo (3.1.0)-hexane derivatives as muscarinic receptor antagonists
DE60225195T2 (de) 2002-12-23 2009-02-26 Ranbaxy Laboratories, Ltd. Flavaxat-derivate als muscarin-rezeptor antagonisten
WO2004056767A1 (en) 2002-12-23 2004-07-08 Ranbaxy Laboratories Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
US7488748B2 (en) 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EP1615881A2 (en) 2003-04-01 2006-01-18 Theravance, Inc. Diarylmethyl and related compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
US7517905B2 (en) 2003-04-09 2009-04-14 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
US7560479B2 (en) 2003-04-10 2009-07-14 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EA009059B1 (ru) 2003-04-10 2007-10-26 Рэнбакси Лабораториз Лимитед Замещенные производные азабициклогексана в качестве антагонистов мускаринового рецептора
JP2006522787A (ja) 2003-04-11 2006-10-05 ランバクシー ラボラトリーズ リミテッド ムスカリン様受容体アンタゴニストとしてのアザビシクロ誘導体
TW200510298A (en) 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
US7368463B2 (en) 2003-07-11 2008-05-06 Theravance, Inc. Substituted 4-amino-1-benzylpiperidine compounds
JP2007528414A (ja) * 2004-03-11 2007-10-11 セラヴァンス， インコーポレーテッド ムスカリンレセプターアンタゴニストとしての有用なジフェニルメチル化合物
EP1723142A1 (en) * 2004-03-11 2006-11-22 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
WO2007024113A1 (en) 2005-08-25 2007-03-01 Rstech Corporation Process for the preparation of chiral 3-hydroxy pyrrolidine compound and derivatives thereof having high optical purity
JP2009512676A (ja) 2005-10-19 2009-03-26 ランバクシー ラボラトリーズ リミテッド ムスカリン性受容体アンタゴニストの医薬組成物
US20070203221A1 (en) * 2005-12-27 2007-08-30 Valeriano Merli Processes for preparing darifenacin hydrobromide
CN101616893B (zh) * 2007-02-23 2014-01-29 施万制药 用作毒蕈碱受体拮抗剂的季铵二苯基甲基化合物
WO2008133900A1 (en) 2007-04-24 2008-11-06 Theravance, Inc. Quaternary ammonium compounds useful as muscarinic receptor antagonists
JP5779100B2 (ja) 2008-11-24 2015-09-16 カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ 光学的に活性なｎ−ベンジル−３−ヒドロキシピロリジンの製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL76583A (en) * 1984-10-19 1988-08-31 Robins Co Inc A H 1-(aminoalkyl)-alpha'alpha-diaryl pyrrolidinyl,piperidino and homopiperidino acetamides and acetonitriles and pharmaceutical compositions containing them
US4810713A (en) * 1985-12-20 1989-03-07 A. H. Robins Company, Incorporated Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment
EP0228893A3 (en) * 1985-12-20 1990-01-03 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl group in allergy treatment
IN163948B (fi) * 1986-01-17 1988-12-10 Robins Co Inc A H
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
US5233053A (en) * 1989-03-17 1993-08-03 Pfizer Inc. Pyrrolidine derivatives

Also Published As

Publication number Publication date
FI95027C (fi) 1995-12-11
DE69014901T2 (de) 1995-04-27
CA2069910C (en) 1996-11-12
ATE115126T1 (de) 1994-12-15
IE64205B1 (en) 1995-07-12
GR3014907T3 (en) 1995-05-31
ES2064771T3 (es) 1995-02-01
WO1991009013A1 (en) 1991-06-27
FI922345A0 (fi) 1992-05-22
CA2069910A1 (en) 1991-06-13
DE69014901D1 (de) 1995-01-19
EP0505376A1 (en) 1992-09-30
JPH0678303B2 (ja) 1994-10-05
PT96144A (pt) 1991-09-30
FI95027B (fi) 1995-08-31
GB8928042D0 (en) 1990-02-14
DK0505376T3 (da) 1995-02-13
US5340831A (en) 1994-08-23
EP0505376B1 (en) 1994-12-07
IE904463A1 (en) 1991-06-19
JPH04505927A (ja) 1992-10-15

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