FI922345A - Förfarande för framställning av terapeutiskt användbara 3-substituerade pyrrolidinderivat - Google Patents

Förfarande för framställning av terapeutiskt användbara 3-substituerade pyrrolidinderivat Download PDF

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Publication number
FI922345A
FI922345A FI922345A FI922345A FI922345A FI 922345 A FI922345 A FI 922345A FI 922345 A FI922345 A FI 922345A FI 922345 A FI922345 A FI 922345A FI 922345 A FI922345 A FI 922345A
Authority
FI
Finland
Prior art keywords
alkyl
pct
preparation
therapeutically useful
date jun
Prior art date
Application number
FI922345A
Other languages
English (en)
Finnish (fi)
Other versions
FI95027C (sv
FI95027B (sv
FI922345A0 (sv
Inventor
Alexander Roderick Mackenzie
Peter Edward Cross
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI922345A publication Critical patent/FI922345A/sv
Publication of FI922345A0 publication Critical patent/FI922345A0/sv
Application granted granted Critical
Publication of FI95027B publication Critical patent/FI95027B/sv
Publication of FI95027C publication Critical patent/FI95027C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI922345A 1989-12-12 1992-05-22 Förfarande för framställning av terapeutiskt användbara 3-substituerade pyrrolidinderivat FI95027C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB898928042A GB8928042D0 (en) 1989-12-12 1989-12-12 Muscarinic receptor antagonists
GB8928042 1989-12-12
PCT/EP1990/002043 WO1991009013A1 (en) 1989-12-12 1990-11-28 Muscarinic receptor antagonists
EP9002043 1990-11-28

Publications (4)

Publication Number Publication Date
FI922345A true FI922345A (sv) 1992-05-22
FI922345A0 FI922345A0 (sv) 1992-05-22
FI95027B FI95027B (sv) 1995-08-31
FI95027C FI95027C (sv) 1995-12-11

Family

ID=10667813

Family Applications (1)

Application Number Title Priority Date Filing Date
FI922345A FI95027C (sv) 1989-12-12 1992-05-22 Förfarande för framställning av terapeutiskt användbara 3-substituerade pyrrolidinderivat

Country Status (14)

Country Link
US (1) US5340831A (sv)
EP (1) EP0505376B1 (sv)
JP (1) JPH0678303B2 (sv)
AT (1) ATE115126T1 (sv)
CA (1) CA2069910C (sv)
DE (1) DE69014901T2 (sv)
DK (1) DK0505376T3 (sv)
ES (1) ES2064771T3 (sv)
FI (1) FI95027C (sv)
GB (1) GB8928042D0 (sv)
GR (1) GR3014907T3 (sv)
IE (1) IE64205B1 (sv)
PT (1) PT96144A (sv)
WO (1) WO1991009013A1 (sv)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6017931A (en) * 1994-03-01 2000-01-25 Fmc Corporation Insecticidal compositions containing n-(substituted phenylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
US5639763A (en) * 1994-03-01 1997-06-17 Fmc Corporation Insecticidal N-(substituted arylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
US5569664A (en) * 1995-02-16 1996-10-29 Fmc Corporation Insecticidal n-(substituted arylmethyl)-4-[bis(substituted phenyl) methyl]pi
EP0948964B1 (en) * 1996-12-02 2003-04-02 Kyorin Pharmaceutical Co., Ltd. Novel n-substituted pyrrolidine derivatives and process for preparing the same
US6693202B1 (en) * 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
CN1668585A (zh) 2002-07-08 2005-09-14 兰贝克赛实验室有限公司 用作蝇蕈碱受体拮抗剂的3,6－二取代氮杂双环[3.1.0]己烷衍生物
US7265147B2 (en) 2002-07-31 2007-09-04 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
US7410993B2 (en) 2002-08-09 2008-08-12 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0] hexane deriviatives useful as muscarinic receptor antagonists
US7288562B2 (en) 2002-08-23 2007-10-30 Ranbaxy Laboratories Limited Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists
TWI295669B (en) * 2002-10-30 2008-04-11 Theravance Inc Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
JP2006518707A (ja) 2002-12-10 2006-08-17 ランバクシー ラボラトリーズ リミテッド ムスカリン様受容体アンタゴニストとしての３，６−二置換アザビシクロ［３．１．０］ヘキサン誘導体
WO2004056767A1 (en) 2002-12-23 2004-07-08 Ranbaxy Laboratories Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
ATE386738T1 (de) 2002-12-23 2008-03-15 Ranbaxy Lab Ltd Flavaxat-derivate als muscarin-rezeptor antagonisten
US7488748B2 (en) 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
WO2004089892A2 (en) 2003-04-01 2004-10-21 Theravance, Inc. Diarylmethyl and related compounds having beta2 andrenergic receptor agonist and muscarinic receptor antagonist activity
AU2003214520A1 (en) 2003-04-09 2004-11-01 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EP1615887A1 (en) 2003-04-10 2006-01-18 Ranbaxy Laboratories, Ltd. Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
AU2003214535B2 (en) 2003-04-10 2009-09-03 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
WO2004089900A1 (en) 2003-04-11 2004-10-21 Ranbaxy Laboratories Limited Azabicyclo derivatives as muscarinic receptor antagonists
TW200510298A (en) 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
WO2005007645A1 (en) * 2003-07-11 2005-01-27 Theravance, Inc. Substituted 4-amino-1-benzylpiperidine compounds
US7250414B2 (en) * 2004-03-11 2007-07-31 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
EP1725525A1 (en) * 2004-03-11 2006-11-29 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
EP1926709A4 (en) 2005-08-25 2009-06-24 Rstech Corp PROCESS FOR THE SYNTHESIS OF A 3-HYDROXYPYRROLIDINE CHIRAL COMPOUND AND DERIVATIVES OF SAID HIGH OPTICAL PURITY COMPOUND
JP2009512676A (ja) 2005-10-19 2009-03-26 ランバクシー ラボラトリーズ リミテッド ムスカリン性受容体アンタゴニストの医薬組成物
CA2630478A1 (en) * 2005-12-27 2007-07-05 Teva Pharmaceutical Industries, Ltd Processes for preparing darifenacin hydrobromide
JP5528817B2 (ja) 2007-02-23 2014-06-25 セラヴァンス， インコーポレーテッド ムスカリン受容体アンタゴニストとして有用な第四級アンモニウムジフェニルメチル化合物
JP2010525058A (ja) 2007-04-24 2010-07-22 セラヴァンス， インコーポレーテッド ムスカリン受容体アンタゴニストとして有用な第４級アンモニウム化合物
JP5779100B2 (ja) 2008-11-24 2015-09-16 カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ 光学的に活性なｎ−ベンジル−３−ヒドロキシピロリジンの製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL76583A (en) * 1984-10-19 1988-08-31 Robins Co Inc A H 1-(aminoalkyl)-alpha'alpha-diaryl pyrrolidinyl,piperidino and homopiperidino acetamides and acetonitriles and pharmaceutical compositions containing them
US4810713A (en) * 1985-12-20 1989-03-07 A. H. Robins Company, Incorporated Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment
EP0235463A3 (en) * 1985-12-20 1990-01-17 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) N-substituted-arylalkyl and arylalkylene piperidines as cardiovascular antihistaminic and antisecretory agents
IN163948B (sv) * 1986-01-17 1988-12-10 Robins Co Inc A H
US5233053A (en) * 1989-03-17 1993-08-03 Pfizer Inc. Pyrrolidine derivatives
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents

Also Published As

Publication number Publication date
EP0505376B1 (en) 1994-12-07
EP0505376A1 (en) 1992-09-30
IE904463A1 (en) 1991-06-19
IE64205B1 (en) 1995-07-12
ES2064771T3 (es) 1995-02-01
PT96144A (pt) 1991-09-30
GR3014907T3 (en) 1995-05-31
US5340831A (en) 1994-08-23
CA2069910C (en) 1996-11-12
JPH0678303B2 (ja) 1994-10-05
ATE115126T1 (de) 1994-12-15
DE69014901T2 (de) 1995-04-27
WO1991009013A1 (en) 1991-06-27
FI95027C (sv) 1995-12-11
FI95027B (sv) 1995-08-31
DE69014901D1 (de) 1995-01-19
JPH04505927A (ja) 1992-10-15
DK0505376T3 (da) 1995-02-13
GB8928042D0 (en) 1990-02-14
CA2069910A1 (en) 1991-06-13
FI922345A0 (sv) 1992-05-22

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