FI922345A0 - Förfarande för framställning av terapeutiskt användbara 3-substituerade pyrrolidinderivat - Google Patents

Förfarande för framställning av terapeutiskt användbara 3-substituerade pyrrolidinderivat

Info

Publication number
FI922345A0
FI922345A0 FI922345A FI922345A FI922345A0 FI 922345 A0 FI922345 A0 FI 922345A0 FI 922345 A FI922345 A FI 922345A FI 922345 A FI922345 A FI 922345A FI 922345 A0 FI922345 A0 FI 922345A0
Authority
FI
Finland
Prior art keywords
alkyl
pct
preparation
therapeutically useful
date jun
Prior art date
Application number
FI922345A
Other languages
English (en)
Finnish (fi)
Other versions
FI922345A (sv
FI95027B (sv
FI95027C (sv
Inventor
Alexander Roderick Mackenzie
Peter Edward Cross
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI922345A publication Critical patent/FI922345A/sv
Publication of FI922345A0 publication Critical patent/FI922345A0/sv
Publication of FI95027B publication Critical patent/FI95027B/sv
Application granted granted Critical
Publication of FI95027C publication Critical patent/FI95027C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI922345A 1989-12-12 1992-05-22 Förfarande för framställning av terapeutiskt användbara 3-substituerade pyrrolidinderivat FI95027C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB898928042A GB8928042D0 (en) 1989-12-12 1989-12-12 Muscarinic receptor antagonists
GB8928042 1989-12-12
EP9002043 1990-11-28
PCT/EP1990/002043 WO1991009013A1 (en) 1989-12-12 1990-11-28 Muscarinic receptor antagonists

Publications (4)

Publication Number Publication Date
FI922345A FI922345A (sv) 1992-05-22
FI922345A0 true FI922345A0 (sv) 1992-05-22
FI95027B FI95027B (sv) 1995-08-31
FI95027C FI95027C (sv) 1995-12-11

Family

ID=10667813

Family Applications (1)

Application Number Title Priority Date Filing Date
FI922345A FI95027C (sv) 1989-12-12 1992-05-22 Förfarande för framställning av terapeutiskt användbara 3-substituerade pyrrolidinderivat

Country Status (14)

Country Link
US (1) US5340831A (sv)
EP (1) EP0505376B1 (sv)
JP (1) JPH0678303B2 (sv)
AT (1) ATE115126T1 (sv)
CA (1) CA2069910C (sv)
DE (1) DE69014901T2 (sv)
DK (1) DK0505376T3 (sv)
ES (1) ES2064771T3 (sv)
FI (1) FI95027C (sv)
GB (1) GB8928042D0 (sv)
GR (1) GR3014907T3 (sv)
IE (1) IE64205B1 (sv)
PT (1) PT96144A (sv)
WO (1) WO1991009013A1 (sv)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5569664A (en) * 1995-02-16 1996-10-29 Fmc Corporation Insecticidal n-(substituted arylmethyl)-4-[bis(substituted phenyl) methyl]pi
US5639763A (en) * 1994-03-01 1997-06-17 Fmc Corporation Insecticidal N-(substituted arylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
US6017931A (en) * 1994-03-01 2000-01-25 Fmc Corporation Insecticidal compositions containing n-(substituted phenylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
ATE235903T1 (de) * 1996-12-02 2003-04-15 Kyorin Seiyaku Kk Neue derivate von n-substituierten pyrrolidin derivaten und deren herstellungsverfahren
US6693202B1 (en) 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
CA2492121A1 (en) 2002-07-08 2004-01-15 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
AU2002368152A1 (en) 2002-07-31 2004-02-25 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo (3.1.0)hexane derivatives useful as muscarinic receptor antagonists
EP1545508A4 (en) 2002-08-09 2009-11-25 Ranbaxy Lab Ltd 3,6-DISUBSTITUTED AZABICYCLO ¬3.1.0 HEXANE DERIVATIVES AS USEFUL AS MUSCARINIC RECEPTOR AGONISTS
ATE423769T1 (de) 2002-08-23 2009-03-15 Ranbaxy Lab Ltd Fluor- und sulfonylaminohaltige, 3,6- disubstituierte azabicyclo 3.1.0 hexanderivate als muscarinrezeptorantagonisten
TW200800953A (en) * 2002-10-30 2008-01-01 Theravance Inc Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine
EP2177511A2 (en) 2002-12-10 2010-04-21 Ranbaxy Laboratories Limited Process for preparing 3,6-disubstituted azabicyclo derivatives
US7465751B2 (en) 2002-12-23 2008-12-16 Ranbaxy Laboratories Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
EP1581522B1 (en) 2002-12-23 2008-02-20 Ranbaxy Laboratories Limited Flavaxate derivatives as muscarinic receptor antagonists
US7488748B2 (en) 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EP1615881A2 (en) 2003-04-01 2006-01-18 Theravance, Inc. Diarylmethyl and related compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
US7517905B2 (en) 2003-04-09 2009-04-14 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
AU2003223010A1 (en) 2003-04-10 2004-11-01 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
AU2003214535B2 (en) 2003-04-10 2009-09-03 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
JP2006522787A (ja) 2003-04-11 2006-10-05 ランバクシー ラボラトリーズ リミテッド ムスカリン様受容体アンタゴニストとしてのアザビシクロ誘導体
TW200510298A (en) 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
US7368463B2 (en) 2003-07-11 2008-05-06 Theravance, Inc. Substituted 4-amino-1-benzylpiperidine compounds
EP1723142A1 (en) * 2004-03-11 2006-11-22 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
WO2005087722A1 (en) * 2004-03-11 2005-09-22 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
EP1926709A4 (en) 2005-08-25 2009-06-24 Rstech Corp PROCESS FOR THE SYNTHESIS OF A 3-HYDROXYPYRROLIDINE CHIRAL COMPOUND AND DERIVATIVES OF SAID HIGH OPTICAL PURITY COMPOUND
RU2008119323A (ru) 2005-10-19 2009-11-27 Рэнбакси Лабораториз Лимитед (In) Фармацевтические композиции мускаринового рецептора
US20070197630A1 (en) * 2005-12-27 2007-08-23 Valeriano Merli Pure darifenacin hydrobromide substantially free of oxidized darifenacin and salts thereof and processes for the preparation thereof
BRPI0807615A8 (pt) * 2007-02-23 2017-12-05 Theravance Inc Compostos de difenilmetil amônico quaternário úteis como antagonistas de receptor muscarínico
WO2008133900A1 (en) 2007-04-24 2008-11-06 Theravance, Inc. Quaternary ammonium compounds useful as muscarinic receptor antagonists
JP5779100B2 (ja) 2008-11-24 2015-09-16 カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ 光学的に活性なｎ−ベンジル−３−ヒドロキシピロリジンの製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL76583A (en) * 1984-10-19 1988-08-31 Robins Co Inc A H 1-(aminoalkyl)-alpha'alpha-diaryl pyrrolidinyl,piperidino and homopiperidino acetamides and acetonitriles and pharmaceutical compositions containing them
US4810713A (en) * 1985-12-20 1989-03-07 A. H. Robins Company, Incorporated Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment
EP0235463A3 (en) * 1985-12-20 1990-01-17 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) N-substituted-arylalkyl and arylalkylene piperidines as cardiovascular antihistaminic and antisecretory agents
IL78939A (en) * 1986-01-17 1990-04-29 Robins Co Inc A H Pharmaceutical compositions containing n-substituted arylalkyl-and arylalkylene-piperidines and tetrahydropyridines and certain such novel compounds
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
US5233053A (en) * 1989-03-17 1993-08-03 Pfizer Inc. Pyrrolidine derivatives

Also Published As

Publication number Publication date
GR3014907T3 (en) 1995-05-31
JPH04505927A (ja) 1992-10-15
DE69014901T2 (de) 1995-04-27
EP0505376B1 (en) 1994-12-07
FI922345A (sv) 1992-05-22
GB8928042D0 (en) 1990-02-14
DK0505376T3 (da) 1995-02-13
ES2064771T3 (es) 1995-02-01
US5340831A (en) 1994-08-23
DE69014901D1 (de) 1995-01-19
PT96144A (pt) 1991-09-30
CA2069910A1 (en) 1991-06-13
EP0505376A1 (en) 1992-09-30
FI95027B (sv) 1995-08-31
FI95027C (sv) 1995-12-11
IE904463A1 (en) 1991-06-19
WO1991009013A1 (en) 1991-06-27
ATE115126T1 (de) 1994-12-15
JPH0678303B2 (ja) 1994-10-05
CA2069910C (en) 1996-11-12
IE64205B1 (en) 1995-07-12

Similar Documents

Publication Publication Date Title
FI922345A0 (sv) Förfarande för framställning av terapeutiskt användbara 3-substituerade pyrrolidinderivat
CA2133413A1 (en) Indole derivatives as 5-ht1 antagonists
HU9301048D0 (en) Acyl-amino-indole derivatives
DK0510003T3 (da) Piperidin-og pyrrolidinderivater
GB9602029D0 (en) New heterocyclic compounds
CA2117643A1 (en) Indole Derivatives
FI97468B (sv) Förfarande för framställning av terapeutiskt aktiv piperidinderivat
DE69510510T2 (de) N-benzoylmethylsubstituierte paroxetinderivate
FI922342A0 (sv) Förfarande för framställning av terapeutiskt användbara 3-fenylglutarimid-derivat
CA2069931A1 (en) Muscarinic receptor antagonists

Legal Events

Date Code Title Description
BB Publication of examined application
MA Patent expired