CA2064558A1 - Methode d'inhibition de la croissance de cellules souches - Google Patents

Methode d'inhibition de la croissance de cellules souches

Info

Publication number
CA2064558A1
CA2064558A1 CA2064558A CA2064558A CA2064558A1 CA 2064558 A1 CA2064558 A1 CA 2064558A1 CA 2064558 A CA2064558 A CA 2064558A CA 2064558 A CA2064558 A CA 2064558A CA 2064558 A1 CA2064558 A1 CA 2064558A1
Authority
CA
Canada
Prior art keywords
stem cells
inhibiting growth
agents
cycling
protecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2064558A
Other languages
English (en)
Other versions
CA2064558C (fr
Inventor
Ian B. Pragnell
Debra D. Donaldson
Gerald J. Graham
Gordon G. Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CRC Technology Ltd
Genetics Institute LLC
Original Assignee
Ian B. Pragnell
Debra D. Donaldson
Gerald J. Graham
Gordon G. Wong
Genetics Institute, Inc.
Crc Technology Ltd.
Genetics Institute, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27021719&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2064558(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ian B. Pragnell, Debra D. Donaldson, Gerald J. Graham, Gordon G. Wong, Genetics Institute, Inc., Crc Technology Ltd., Genetics Institute, Llc filed Critical Ian B. Pragnell
Publication of CA2064558A1 publication Critical patent/CA2064558A1/fr
Application granted granted Critical
Publication of CA2064558C publication Critical patent/CA2064558C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Procédé de protection de cellules souches cycliques ou à division des effets cytotoxiques d'agents et de rayonnement chimiothérapeutiques, par administration avant l'exposition à ces agents, d'une quantité efficace de facteur inhibiteur de cellules souches ainsi que d'une composition utile à cet effet.
CA002064558A 1989-09-25 1990-09-25 Methode d'inhibition de la croissance de cellules souches Expired - Lifetime CA2064558C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41230389A 1989-09-25 1989-09-25
US412,303 1989-09-25
US58171390A 1990-09-13 1990-09-13
US581,713 1990-09-13
PCT/US1990/005451 WO1991004274A1 (fr) 1989-09-25 1990-09-25 Procede d'inhibition de la croissance de cellules souches

Publications (2)

Publication Number Publication Date
CA2064558A1 true CA2064558A1 (fr) 1991-03-26
CA2064558C CA2064558C (fr) 2001-01-30

Family

ID=27021719

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002064558A Expired - Lifetime CA2064558C (fr) 1989-09-25 1990-09-25 Methode d'inhibition de la croissance de cellules souches

Country Status (10)

Country Link
US (1) US5674841A (fr)
EP (1) EP0494268B2 (fr)
JP (1) JPH05502443A (fr)
AT (1) ATE124421T1 (fr)
CA (1) CA2064558C (fr)
DE (1) DE69020573T3 (fr)
DK (1) DK0494268T4 (fr)
ES (1) ES2076378T5 (fr)
MX (1) MX9203438A (fr)
WO (1) WO1991004274A1 (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06503710A (ja) * 1990-09-14 1994-04-28 カイロン　コーポレイション 酵母細胞におけるマクロファージ誘導タンパク質（ｍｉｐ）の発現
US6057123A (en) * 1991-12-23 2000-05-02 British Biotech Pharmaceuticals Limited Stem cell inhibiting proteins
FR2691153B1 (fr) * 1992-05-18 1995-06-30 Serbio Dodecapeptides monomere et dimere, utilisation en tant qu'agents anti-megacaryocytaires.
US6610654B2 (en) 1993-03-31 2003-08-26 Wellstat Therapeutics Corporation Inhibitor of stem cell proliferation and uses thereof
CN1089344C (zh) * 1993-03-31 2002-08-21 普罗神经细胞有限公司 干细胞增生的抑制剂及其应用
US5939391A (en) * 1993-03-31 1999-08-17 Pro-Neuron, Inc. Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
GB9308060D0 (en) * 1993-04-19 1993-06-02 Cancer Res Campaign Tech Stem cell inhibitor
EP0703784B1 (fr) * 1993-06-15 2002-03-06 British Biotech Pharmaceuticals Limited Liberation et mobilisation de cellules hematopoietiques
US6488925B2 (en) 1993-12-22 2002-12-03 Human Genome Sciences, Inc. Macrophage inflammatory protein-4 (MIP-4) polypeptides
US6001606A (en) * 1994-03-08 1999-12-14 Human Genome Sciences, Inc. Polynucleotides encoding myeloid progenitor inhibitory factor-1 (MPIF-1) and polypeptides encoded thereby
US6811773B1 (en) 1993-12-22 2004-11-02 Human Genome Sciences, Inc. Human monocyte colony inhibitory factor (M-CIF) polypeptides
US6623942B2 (en) 1994-03-08 2003-09-23 Human Genome Sciences, Inc. Macrophage inflammatory protein-4 (MIP-4) polynucleotides
US6495129B1 (en) 1994-03-08 2002-12-17 Human Genome Sciences, Inc. Methods of inhibiting hematopoietic stem cells using human myeloid progenitor inhibitory factor-1 (MPIF-1) (Ckbeta-8/MIP-3)
ATE216425T1 (de) * 1994-08-13 2002-05-15 Roche Diagnostics Gmbh Verwendung von interferon-gamma zur vermeidung der proliferation und differenzierung der primitiven hämapoietischen vorläuferzellen
EP0696639B1 (fr) * 1994-08-13 2002-04-17 Boehringer Mannheim Gmbh Utilisation du Interferon-gamma pour l'inhibition de la prolifération et différentiation des cellules primitives hématopoietiques
US6391589B1 (en) 1994-08-23 2002-05-21 Human Genome Sciences, Inc. Human chemokine beta-10 mutant polypeptides
US6174995B1 (en) 1994-08-23 2001-01-16 Haodong Li Human chemokines, CKβ4 and CKβ10/MCP-4
US5981230A (en) * 1994-08-23 1999-11-09 Human Genome Sciences, Inc. Polynucleotide encoding chemokine β-4
US6458349B1 (en) 1995-06-02 2002-10-01 Human Genome Sciences, Inc. Chemokine β-4 polypeptides
US6139832A (en) * 1995-02-08 2000-10-31 Human Genome Sciences, Inc. Leukocyte adhesion inhibitor-1 (LAI-1) Polypeptides
US6040431A (en) * 1995-06-07 2000-03-21 Stryker Corporation Single chain analogs of the TGF-β superfamily (morphons)
AU1840897A (en) * 1996-02-09 1997-08-28 Katholieke Universiteit Nijmegen Mammalian dendritic cell chemokine reagents
US6410268B1 (en) 1996-03-18 2002-06-25 Human Genome Sciences, Inc. Polynucleotides encoding chemokine alpha-3
US5910431A (en) * 1996-03-19 1999-06-08 Human Genome Sciences, Inc. Polynucleotides encoding chemokine α-2
US5861483A (en) 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
US6290948B1 (en) * 1996-05-14 2001-09-18 Smithkline Beecham Corporation Method of treating sepsis and ARDS using chamohine beta-10
AU762472B2 (en) 1998-03-13 2003-06-26 University Of British Columbia, The Therapeutic chemokine receptor antagonists
CA2305787A1 (fr) 2000-05-09 2001-11-09 The University Of British Columbia Traitement antagoniste cxcr4 de cellules hematopoietiques
CA2245224A1 (fr) 1998-08-14 2000-02-14 Jiang-Hong Giong Antagonistes du recepteur de la chimiokine et chimiotherapie
US7097832B1 (en) 1999-03-30 2006-08-29 Myocardial Therapeutics, Inc. Intramyocardial injection of autologous bone marrow
DK1171165T3 (da) * 1999-03-30 2007-09-03 Ran Kornowski Injektion af autolog knoglemarv i myokardiet
US7368425B2 (en) 2006-03-24 2008-05-06 Chemokine Therapeutics Corp. Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis
CA2335109A1 (fr) * 2000-04-12 2001-10-12 Chemokine Therapeutics Corporation Traitement de cellules hematopoietiques avec des agonistes du cxcr4
US20050059584A1 (en) 2002-08-16 2005-03-17 Ahmed Merzouk Novel chemokine mimetics synthesis and their use
US7378098B2 (en) 2000-04-12 2008-05-27 The University Of British Columbia CXC chemokine receptor 4 agonist peptides
JP2004504834A (ja) 2000-08-01 2004-02-19 イスム　リサーチ　ディベロップメント　カンパニー 胚性細胞の定方向分化
AU2003225237A1 (en) 2002-05-01 2003-11-17 Human Genome Sciences, Inc. Antibodies that specifically bind to chemokine beta-4
US8921315B1 (en) * 2008-04-24 2014-12-30 Neumedicines, Inc. Method of increasing survival of a human subject having exposure to an acute exposure to non-therapeutic whole body ionization by administering a therapeutically effective dose of IL-12
KR101919170B1 (ko) 2010-11-19 2018-11-15 에자이 알앤드디 매니지먼트 가부시키가이샤 중화 항-ccl20 항체

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4822776A (en) * 1981-09-08 1989-04-18 The Rockefeller University Lipoprotein lipase suppression by endotoxin-induced mediator (shock assay)
DK175308B1 (da) * 1987-09-28 2004-08-16 Pfizer En vaccinekomposition omfattende et inaktiveret virus eller bakterium, fremgangsmåde til fremstilling deraf samt anvendelsen af en substans eller en komposition i fremstillingen deraf
US5041289A (en) * 1987-11-13 1991-08-20 Becton Dickinson And Company Method of purging residual tumor cells in vitro with lymphokine activated cytotoxic cells
JPH04500970A (ja) * 1988-09-02 1992-02-20 ザ ロックフェラー ユニヴァーシティ マクロファージ由来炎症メディエーター　（ｍｉｐ―２）
WO1991000103A1 (fr) * 1989-06-29 1991-01-10 The United States Of America, Represented By The Secretary, United States Department Of Commerce Methode pour proteger la m×lle osseuse contre les medicaments chimiotherapiques et radiotherapie utilisant le facteur de croissance de transformation beta 1

Also Published As

Publication number Publication date
EP0494268B2 (fr) 1999-04-28
CA2064558C (fr) 2001-01-30
DK0494268T3 (da) 1995-08-28
US5674841A (en) 1997-10-07
DE69020573D1 (de) 1995-08-03
DE69020573T3 (de) 1999-12-16
DE69020573T2 (de) 1995-11-30
ES2076378T5 (es) 1999-10-16
MX9203438A (es) 1992-07-01
WO1991004274A1 (fr) 1991-04-04
DK0494268T4 (da) 1999-11-08
ATE124421T1 (de) 1995-07-15
JPH05502443A (ja) 1993-04-28
EP0494268B1 (fr) 1995-06-28
EP0494268A1 (fr) 1992-07-15
ES2076378T3 (es) 1995-11-01

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