DE69020573D1 - Verfahren zur wachstumshemmung von stammzellen. - Google Patents

Verfahren zur wachstumshemmung von stammzellen.

Info

Publication number
DE69020573D1
DE69020573D1 DE69020573T DE69020573T DE69020573D1 DE 69020573 D1 DE69020573 D1 DE 69020573D1 DE 69020573 T DE69020573 T DE 69020573T DE 69020573 T DE69020573 T DE 69020573T DE 69020573 D1 DE69020573 D1 DE 69020573D1
Authority
DE
Germany
Prior art keywords
stem cells
inhibiting stem
agents
inhibiting
cycling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69020573T
Other languages
English (en)
Other versions
DE69020573T3 (de
DE69020573T2 (de
Inventor
Ian Pragnell
Debra Donaldson
Gerald Graham
Gordon Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CRC Technology Ltd
Genetics Institute LLC
Original Assignee
CRC Technology Ltd
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27021719&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69020573(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by CRC Technology Ltd, Genetics Institute LLC filed Critical CRC Technology Ltd
Application granted granted Critical
Publication of DE69020573D1 publication Critical patent/DE69020573D1/de
Publication of DE69020573T2 publication Critical patent/DE69020573T2/de
Publication of DE69020573T3 publication Critical patent/DE69020573T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
DE69020573T 1989-09-25 1990-09-25 Verfahren zur wachstumshemmung von stammzellen. Expired - Lifetime DE69020573T3 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41230389A 1989-09-25 1989-09-25
US58171390A 1990-09-13 1990-09-13
PCT/US1990/005451 WO1991004274A1 (en) 1989-09-25 1990-09-25 Method for inhibiting growth of stem cells

Publications (3)

Publication Number Publication Date
DE69020573D1 true DE69020573D1 (de) 1995-08-03
DE69020573T2 DE69020573T2 (de) 1995-11-30
DE69020573T3 DE69020573T3 (de) 1999-12-16

Family

ID=27021719

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69020573T Expired - Lifetime DE69020573T3 (de) 1989-09-25 1990-09-25 Verfahren zur wachstumshemmung von stammzellen.

Country Status (10)

Country Link
US (1) US5674841A (de)
EP (1) EP0494268B2 (de)
JP (1) JPH05502443A (de)
AT (1) ATE124421T1 (de)
CA (1) CA2064558C (de)
DE (1) DE69020573T3 (de)
DK (1) DK0494268T4 (de)
ES (1) ES2076378T5 (de)
MX (1) MX9203438A (de)
WO (1) WO1991004274A1 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE177472T1 (de) * 1990-09-14 1999-03-15 Chiron Corp Expression von makrophagen-induzierbaren proteinen (mips) in hefezellen
JPH07502404A (ja) * 1991-12-23 1995-03-16 ブリティッシュ　バイオ−テクノロジー　リミテッド 幹細胞阻害タンパク質
FR2691153B1 (fr) * 1992-05-18 1995-06-30 Serbio Dodecapeptides monomere et dimere, utilisation en tant qu'agents anti-megacaryocytaires.
RU2155066C2 (ru) * 1993-03-31 2000-08-27 Про-Ньюрон, Инк. Ингибитор пролиферации стволовых клеток и его использование
US5939391A (en) * 1993-03-31 1999-08-17 Pro-Neuron, Inc. Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
US6610654B2 (en) 1993-03-31 2003-08-26 Wellstat Therapeutics Corporation Inhibitor of stem cell proliferation and uses thereof
GB9308060D0 (en) * 1993-04-19 1993-06-02 Cancer Res Campaign Tech Stem cell inhibitor
EP0703784B1 (de) * 1993-06-15 2002-03-06 British Biotech Pharmaceuticals Limited Freisetzung und Mobilisierung hämatopoietischer Zellen
US6488925B2 (en) 1993-12-22 2002-12-03 Human Genome Sciences, Inc. Macrophage inflammatory protein-4 (MIP-4) polypeptides
US6001606A (en) * 1994-03-08 1999-12-14 Human Genome Sciences, Inc. Polynucleotides encoding myeloid progenitor inhibitory factor-1 (MPIF-1) and polypeptides encoded thereby
US6811773B1 (en) 1993-12-22 2004-11-02 Human Genome Sciences, Inc. Human monocyte colony inhibitory factor (M-CIF) polypeptides
US6623942B2 (en) 1994-03-08 2003-09-23 Human Genome Sciences, Inc. Macrophage inflammatory protein-4 (MIP-4) polynucleotides
US6495129B1 (en) 1994-03-08 2002-12-17 Human Genome Sciences, Inc. Methods of inhibiting hematopoietic stem cells using human myeloid progenitor inhibitory factor-1 (MPIF-1) (Ckbeta-8/MIP-3)
DE69526395D1 (de) * 1994-08-13 2002-05-23 Roche Diagnostics Gmbh Verwendung von Interferon-gamma zur Vermeidung der Proliferation und Differenzierung der primitiven Hämapoietischen Vorläuferzellen
EP0696639B1 (de) * 1994-08-13 2002-04-17 Boehringer Mannheim Gmbh Verwendung von Interferon-gamma zur Vermeidung der Proliferation und Differenzierung der primitiven Hämapoietischen Vorläuferzellen
US6391589B1 (en) 1994-08-23 2002-05-21 Human Genome Sciences, Inc. Human chemokine beta-10 mutant polypeptides
US6458349B1 (en) 1995-06-02 2002-10-01 Human Genome Sciences, Inc. Chemokine β-4 polypeptides
US6174995B1 (en) 1994-08-23 2001-01-16 Haodong Li Human chemokines, CKβ4 and CKβ10/MCP-4
US5981230A (en) * 1994-08-23 1999-11-09 Human Genome Sciences, Inc. Polynucleotide encoding chemokine β-4
US6139832A (en) 1995-02-08 2000-10-31 Human Genome Sciences, Inc. Leukocyte adhesion inhibitor-1 (LAI-1) Polypeptides
US6040431A (en) * 1995-06-07 2000-03-21 Stryker Corporation Single chain analogs of the TGF-β superfamily (morphons)
WO1997029125A1 (en) * 1996-02-09 1997-08-14 Schering Corporation Mammalian dendritic cell chemokine reagents
US6410268B1 (en) 1996-03-18 2002-06-25 Human Genome Sciences, Inc. Polynucleotides encoding chemokine alpha-3
JP2000507101A (ja) 1996-03-19 2000-06-13 ヒューマン・ジェノム・サイエンシズ・インコーポレイテッド ケモカインアルファ２
US5861483A (en) * 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
US6290948B1 (en) * 1996-05-14 2001-09-18 Smithkline Beecham Corporation Method of treating sepsis and ARDS using chamohine beta-10
CA2245224A1 (en) 1998-08-14 2000-02-14 Jiang-Hong Giong Chemokine receptor antagonists and chemotherapeutics
CA2305787A1 (en) 2000-05-09 2001-11-09 The University Of British Columbia Cxcr4 antagonist treatment of hematopoietic cells
DE69914463T2 (de) 1998-03-13 2004-11-11 The University Of British Columbia, Vancouver Therapeutische chemokine rezeptor antagonisten
EP1171165B1 (de) * 1999-03-30 2007-05-30 Ran Kornowski Injektion von autologem knochenmark in den herzmuskel
US7097832B1 (en) 1999-03-30 2006-08-29 Myocardial Therapeutics, Inc. Intramyocardial injection of autologous bone marrow
CA2335109A1 (en) * 2000-04-12 2001-10-12 Chemokine Therapeutics Corporation Cxcr4 agonist treatment of hematopoietic cells
US20050059584A1 (en) 2002-08-16 2005-03-17 Ahmed Merzouk Novel chemokine mimetics synthesis and their use
US7378098B2 (en) 2000-04-12 2008-05-27 The University Of British Columbia CXC chemokine receptor 4 agonist peptides
US7368425B2 (en) 2006-03-24 2008-05-06 Chemokine Therapeutics Corp. Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis
US7045353B2 (en) 2000-08-01 2006-05-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Directed differentiation of human embryonic cells
US7375192B2 (en) 2002-05-01 2008-05-20 Human Genome Sciences, Inc. Antibodies that specifically bind to chemokine beta-4
US8921315B1 (en) * 2008-04-24 2014-12-30 Neumedicines, Inc. Method of increasing survival of a human subject having exposure to an acute exposure to non-therapeutic whole body ionization by administering a therapeutically effective dose of IL-12
AU2011329647B2 (en) 2010-11-19 2015-10-22 Eisai R&D Management Co., Ltd. Neutralizing anti-CCL20 antibodies

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4822776A (en) * 1981-09-08 1989-04-18 The Rockefeller University Lipoprotein lipase suppression by endotoxin-induced mediator (shock assay)
EP0310317B1 (de) * 1987-09-28 1993-12-15 Beecham Inc. Inaktivierung von Viren und Bakterien
US5041289A (en) * 1987-11-13 1991-08-20 Becton Dickinson And Company Method of purging residual tumor cells in vitro with lymphokine activated cytotoxic cells
EP0394409B1 (de) * 1988-09-02 1997-06-11 The Rockefeller University Makrophagenabgeleiteter entzündungsmediator(mip-2)
AU5958090A (en) * 1989-06-29 1991-01-17 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Method for protecting bone marrow against chemotherapeutic drugs and radiation therapy using transforming growth factor beta 1

Also Published As

Publication number Publication date
ES2076378T5 (es) 1999-10-16
WO1991004274A1 (en) 1991-04-04
US5674841A (en) 1997-10-07
DK0494268T3 (da) 1995-08-28
DE69020573T3 (de) 1999-12-16
EP0494268B2 (de) 1999-04-28
DK0494268T4 (da) 1999-11-08
DE69020573T2 (de) 1995-11-30
CA2064558A1 (en) 1991-03-26
ES2076378T3 (es) 1995-11-01
CA2064558C (en) 2001-01-30
ATE124421T1 (de) 1995-07-15
EP0494268A1 (de) 1992-07-15
MX9203438A (es) 1992-07-01
EP0494268B1 (de) 1995-06-28
JPH05502443A (ja) 1993-04-28

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings
8327 Change in the person/name/address of the patent owner

Owner name: CRC TECHNOLOGY LTD., LONDON, GB

Owner name: GENETICS INSTITUTE,LLC(N.D.GES.D.STAATES DELAWARE)