CA2059377A1 - Fabrication d'articles hydrophiles gonflant dans l'eau et dispositifs d'administration de medicaments - Google Patents

Fabrication d'articles hydrophiles gonflant dans l'eau et dispositifs d'administration de medicaments

Info

Publication number
CA2059377A1
CA2059377A1 CA2059377A CA2059377A CA2059377A1 CA 2059377 A1 CA2059377 A1 CA 2059377A1 CA 2059377 A CA2059377 A CA 2059377A CA 2059377 A CA2059377 A CA 2059377A CA 2059377 A1 CA2059377 A1 CA 2059377A1
Authority
CA
Canada
Prior art keywords
drug delivery
delivery devices
manufacture
water
plastic cartridge
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2059377A
Other languages
English (en)
Other versions
CA2059377C (fr
Inventor
Peter Kuzma
Daniel Moro
Harry Quandt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indevus Pharmaceuticals Inc
Original Assignee
Valera Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US07/621,346 priority Critical patent/US5266325A/en
Priority to AU10183/92A priority patent/AU651654B2/en
Priority to CA002059377A priority patent/CA2059377C/fr
Application filed by Valera Pharmaceuticals Inc filed Critical Valera Pharmaceuticals Inc
Priority to AT92300394T priority patent/ATE149345T1/de
Priority to EP92300394A priority patent/EP0551698B1/fr
Priority to DE69217900T priority patent/DE69217900T2/de
Priority to DK92300394.1T priority patent/DK0551698T3/da
Priority to US08/041,523 priority patent/US5292515A/en
Publication of CA2059377A1 publication Critical patent/CA2059377A1/fr
Application granted granted Critical
Publication of CA2059377C publication Critical patent/CA2059377C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
    • B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • B29C41/04—Rotational or centrifugal casting, i.e. coating the inside of a mould by rotating the mould
    • B29C41/042—Rotational or centrifugal casting, i.e. coating the inside of a mould by rotating the mould by rotating a mould around its axis of symmetry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
    • B29C41/34—Component parts, details or accessories; Auxiliary operations
    • B29C41/50—Shaping under special conditions, e.g. vacuum
CA002059377A 1990-09-28 1992-01-15 Fabrication d'articles hydrophiles gonflant dans l'eau et dispositifs d'administration de medicaments Expired - Lifetime CA2059377C (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US07/621,346 US5266325A (en) 1990-09-28 1990-12-03 Preparation of homogeneous hydrogel copolymers
AU10183/92A AU651654B2 (en) 1992-01-14 1992-01-14 Manufacture of water-swellable hydrophilic articles and drug delivery devices
CA002059377A CA2059377C (fr) 1992-01-14 1992-01-15 Fabrication d'articles hydrophiles gonflant dans l'eau et dispositifs d'administration de medicaments
EP92300394A EP0551698B1 (fr) 1992-01-14 1992-01-16 Fabrication d'articles hydrophiles hydro-gonflables et dispositifs de délivrance de médicaments
AT92300394T ATE149345T1 (de) 1992-01-14 1992-01-16 Herstellung von in wasser quellbaren hydrophilen gegenständen sowie arzneistoffabgabesystemen
DE69217900T DE69217900T2 (de) 1992-01-14 1992-01-16 Herstellung von in Wasser quellbaren hydrophilen Gegenständen sowie Arzneistoffabgabesystemen
DK92300394.1T DK0551698T3 (da) 1992-01-14 1992-01-16 Fremstilling af vandkvældelige, hydrofile genstande og lægemiddeltilførselsanordninger
US08/041,523 US5292515A (en) 1990-09-28 1993-03-31 Manufacture of water-swellable hydrophilic articles and drug delivery devices

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AU10183/92A AU651654B2 (en) 1992-01-14 1992-01-14 Manufacture of water-swellable hydrophilic articles and drug delivery devices
CA002059377A CA2059377C (fr) 1992-01-14 1992-01-15 Fabrication d'articles hydrophiles gonflant dans l'eau et dispositifs d'administration de medicaments
EP92300394A EP0551698B1 (fr) 1992-01-14 1992-01-16 Fabrication d'articles hydrophiles hydro-gonflables et dispositifs de délivrance de médicaments
US08/041,523 US5292515A (en) 1990-09-28 1993-03-31 Manufacture of water-swellable hydrophilic articles and drug delivery devices

Publications (2)

Publication Number Publication Date
CA2059377A1 true CA2059377A1 (fr) 1993-07-16
CA2059377C CA2059377C (fr) 1996-08-27

Family

ID=27422426

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002059377A Expired - Lifetime CA2059377C (fr) 1990-09-28 1992-01-15 Fabrication d'articles hydrophiles gonflant dans l'eau et dispositifs d'administration de medicaments

Country Status (7)

Country Link
US (1) US5292515A (fr)
EP (1) EP0551698B1 (fr)
AT (1) ATE149345T1 (fr)
AU (1) AU651654B2 (fr)
CA (1) CA2059377C (fr)
DE (1) DE69217900T2 (fr)
DK (1) DK0551698T3 (fr)

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US5487739A (en) * 1987-11-17 1996-01-30 Brown University Research Foundation Implantable therapy systems and methods
US5662913A (en) * 1991-04-10 1997-09-02 Capelli; Christopher C. Antimicrobial compositions useful for medical applications
US5800829A (en) * 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
AU666118B2 (en) * 1991-04-25 1996-02-01 Brown University Research Foundation Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
US6110481A (en) * 1994-03-04 2000-08-29 Trustees Of The Stevens Institute Of Technology Controlled release device based on aqueous-organic partitioning in porous membranes
US5876743A (en) * 1995-03-21 1999-03-02 Den-Mat Corporation Biocompatible adhesion in tissue repair
US5733565A (en) * 1996-02-23 1998-03-31 The Population Council, Center For Biomedical Research Male contraceptive implant
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US6200589B1 (en) 1996-09-13 2001-03-13 The University Of Akron Biological implants of semipermeable amphiphilic membranes
JP4215188B2 (ja) * 1997-12-22 2009-01-28 インターシア セラピューティクス，インコーポレイティド 薬剤供給を調節するデバイスのための速度調節膜
US6117441A (en) * 1998-07-02 2000-09-12 The Population Council, Inc. Silicone core long term androgen delivery implant
US6361797B1 (en) * 1999-01-28 2002-03-26 Hydro Med Sciences, Inc. Hydrogel compositions useful for the sustained release of macromolecules and methods of making same
WO2001012746A1 (fr) * 1999-08-17 2001-02-22 Porex Technologies Corporation Matieres auto-obturantes et dispositifs comprenant ces dernieres
US6365171B1 (en) 1999-11-04 2002-04-02 The University Of Akron Amphiphilic networks, implantable immunoisolatory devices and methods of preparation
US6969480B2 (en) * 2000-05-12 2005-11-29 Matregen Corp. Method of producing structures using centrifugal forces
AU5812701A (en) * 2000-05-12 2001-11-20 Paul D Dalton Method of producing structures using centrifugal forces
DE10210626A1 (de) * 2002-03-11 2003-09-25 Transmit Technologietransfer Verfahren zur Herstellung von Hohlfasern
US7351430B2 (en) * 2002-11-06 2008-04-01 Uluru Inc. Shape-retentive hydrogel particle aggregates and their uses
US7811605B2 (en) * 2002-11-06 2010-10-12 Uluru Inc. Method of formation of shape-retentive aggregates of gel particles and their uses
US7858110B2 (en) 2003-08-11 2010-12-28 Endo Pharmaceuticals Solutions, Inc. Long term drug delivery devices with polyurethane based polymers and their manufacture
CA2437639C (fr) 2003-08-11 2016-07-05 Valera Pharmaceuticals, Inc. Dispositifs de distribution de medicaments a long terme dotes de polymeres a base de polyurethane et leur fabrication
US20090208540A1 (en) * 2003-08-11 2009-08-20 Indevus Pharmaceuticals, Inc. Implantable device for the delivery of naltrexone and methods of use thereof
BRPI0510260A (pt) 2004-04-27 2007-10-23 Wyeth Corp método para purificar um composto, e, kit farmacêutico
WO2006009801A2 (fr) * 2004-06-17 2006-01-26 Valera Pharmaceuticals, Inc. Compositions et methodes de traitement de la puberte centrale precoce
EP1888043A4 (fr) * 2005-03-11 2010-07-28 Endo Pharmaceuticals Solutions Preparation d'octreotide a liberation lente
US7759312B2 (en) * 2005-03-11 2010-07-20 Endo Pharmaceuticals Solutions Inc. Delivery of dry formulations of octreotide
FR2885512B1 (fr) * 2005-05-10 2007-08-10 Biocoral Inc Seringue pour bio-materiau
WO2006122414A1 (fr) * 2005-05-17 2006-11-23 Matregen Corp. Sites tissulaires de stockage utilises pour l'apport prolonge et regule de methotrexate
US7910135B2 (en) * 2006-10-13 2011-03-22 Uluru Inc. Hydrogel wound dressing and biomaterials formed in situ and their uses
US20080228268A1 (en) * 2007-03-15 2008-09-18 Uluru, Inc. Method of Formation of Viscous, Shape Conforming Gels and Their Uses as Medical Prosthesis
EP2139533A2 (fr) * 2007-04-27 2010-01-06 Endo Pharmaceuticals Solutions Inc. Agents de démoulage d'implants et procédés d'utilisation
WO2009143404A1 (fr) * 2008-05-23 2009-11-26 Wyeth Pipérazine utilisée en tant que modulateurs allostériques négatifs agissant sur le récepteur métabotropique du glutamate de type 5 (mglur5)
AU2009262263B2 (en) * 2008-06-25 2014-08-14 Endo Pharmaceuticals Solutions Inc. Octreotide implant having a release agent
JP5622725B2 (ja) * 2008-06-25 2014-11-12 エンド ファーマスーティカルズ ソリューションズ インコーポレイテッド．Ｅｎｄｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｓｏｌｕｔｉｏｎｓｉｎｃ． エキセナチド及び他のポリペプチド類の持続的送達
WO2010039643A1 (fr) * 2008-09-30 2010-04-08 Endo Pharmaceuticals Solutions Inc. Dispositif implantable pour l’administration d’histréline et procédés d’utilisation de celui-ci
MX2011003301A (es) * 2008-09-30 2011-06-09 Endo Pharmaceuticals Solutions Dispositivo implantable para el suministro de risperidona y metodos de uso del mismo.
EP2498764B1 (fr) 2009-11-09 2017-09-06 Spotlight Technology Partners LLC Hydrogels fragmentés
CA2780294C (fr) 2009-11-09 2018-01-16 Spotlight Technology Partners Llc Hydrogels a base de polysaccharide
US8329219B2 (en) 2009-12-22 2012-12-11 Cook Biotech Incorporated Methods for producing ECM-based biomaterials
US8360765B2 (en) * 2011-01-07 2013-01-29 Covidien Lp Systems and method for forming a coaxial implant
WO2012172449A1 (fr) 2011-06-13 2012-12-20 Pfizer Inc. Lactames convenant comme inhibiteurs des bêta-sécrétases
DK2771320T3 (en) 2011-10-24 2016-10-03 Endo Pharmaceuticals Inc Cyclohexylamines
CN106029660B (zh) 2013-12-16 2019-11-15 阿萨纳生物科技有限责任公司 P2x3和/或p2x2/3化合物和方法
TW201642820A (zh) * 2015-02-19 2016-12-16 健生生物科技公司 細胞封裝加載裝置
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Also Published As

Publication number Publication date
DE69217900D1 (de) 1997-04-10
CA2059377C (fr) 1996-08-27
US5292515A (en) 1994-03-08
ATE149345T1 (de) 1997-03-15
EP0551698A1 (fr) 1993-07-21
AU1018392A (en) 1993-07-15
EP0551698B1 (fr) 1997-03-05
DE69217900T2 (de) 1997-06-12
DK0551698T3 (da) 1997-10-13
AU651654B2 (en) 1994-07-28

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